IL-1β and iNOS can drive the asthmatic comorbidities and decrease of lung function in perennial allergic rhinitis children

Table 1 Comparison of inflammatory parameters (geometric mean and 95% CI) of the PAR alone group and PAR with asthma group (N = 240)

	PAR (N = 113)	95% CI	PAR with asthma (N = 127)	95% CI	p-value
Total IgE (IU/mL)	82.43	63.48-107.03	68.40	53.47–87.48	0.71
Eosinophils (%)	2.40	2.12–2.72	2.30	2.05–2.58	0.18
IL-1ß (pg/ml)	0.53	0.41–0.67	0.79	0.57–1.11	0.05
CCL24 (pg/ml)	196.21	162.28-237.24	236.54	199.64-280.24	0.007
iNOS (ng/ml)	14.42	10.36–20.09	56.32	45.18–70.20	< 0.001
E-cadherin(pg/ml)	102.78	97.06-108.82	89.20	79.64–99.91	0.03
Vimentin (pg/ml)	392.17	357.33–430.40	433.63	346.44-542.77	0.25

PAR perennial allergic rhinitis, IL interleukin, CCL C–C motif chemokine ligand, iNOS inducible nitric oxide synthase, CI confidence interval

ISSN: 1710-1492