Different expression levels of interleukin-36 in asthma phenotypes

Table 1 Characteristics of asthma patients and healthy non-asthmatic controls

Variable	Asthma	Normal	P value
Number	62	16
Age, years	54.77 ± 15.49	54.25 ± 14.60	0.903
Sex, male, n (%)	27 (43.5)	10 (62.5)	0.179
BMI, kg/m²	24.10 ± 3.76	23.75 ± 3.45	0.632
Ex-smoker, n (%)	29 (46.8)	5 (31.3)	0.267
Pre-FEV1, L	1.78 ± 0.80	2.70 ± 0.78	< 0.001
Post-FEV1, L	2.06 ± 0.80	2.78 ± 0.80	0.002
Post-FVC, L	3.03 ± 0.81	3.45 ± 0.91	0.075
Post-bronchodilator FEV1/pred (%)	73.94 ± 23.96	97.68 ± 11.80	< 0.001
Post-bronchodilator FVC/pred (%)	89.90 ± 18.95	101.04 ± 12.48	0.029
Post-bronchodilator FEV1/FVC (%)	66.86 ± 14.57	80.16 ± 3.89	0.001
Sputum TCC, 10⁶/mL	0.97 (0.44,2.60)	1.65 (0.95,2.35)	0.319
Sputum NEU, 10⁴/mL	4.05 (0.58,49.65)	0.60 (0.23,0.93)	0.001
Sputum EOS, 10⁴/mL	2.95 (0.20,9.28)	0.00 (0.00,0.10)	< 0.001
Sputum MA, 10⁶/mL	71.45 (26.75,88.78)	98.15 (97.85,99.08)	< 0.001
Sputum LY, 10⁴/mL	6.00 (1.68,10.05)	0.65 (0.28,1.18)	< 0.001

Data are expressed as mean ± SD or median (IQR). Data were analyzed by Student’s t test or Mann–Whitney U test after adjusting for age
BMI body mass index, FEV1 forced expiratory volume in 1 s, FVC forced vital capacity, TCC total cell count, NEU neutrophils, EOS eosinophils, MA Macrophages, LY lymphocytes

ISSN: 1710-1492