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Table 3 Comparison between patients with and without OSA

From: The prevalence of obstructive sleep apnea in Japanese asthma patients

 

Without OSA

(n = 17)

With OSA

(n = 36)

P value

Male/Female, n (%)

2/15

11/25

0.25

Age, years

59.8 ± 16.8

58.7 ± 16.5

0.83

Age at asthma onset, years

30.5 ± 22.8

58.7 ± 16.5

0.16

BMI, kg/m2

23.1 ± 3.85

27.9 ± 6.6

< 0.01

Smoking status: Never/Ex./Current, n (%)

13 (76.5)/2 (11.8)/2 (11.8)

16 (44.5)/12 (33.3)/8 (22.2)

0.29

Brinkman Index

147.1 ± 398.6

290.5 ± 365.3

0.03

Hypertension, n (%)

3 (17.6)

16 (44.4)

0.07

Diabetes, n (%)

2 (11.8)

12 (33.3)

0.18

BNP, pg/ml

28.6 ± 48.3

43.0 ± 82.9

0.17

GINA step (1/2/3/4/5), n (%)

0/0/7 /7 /3

0/1/9/19/7

0.84

Allergic rhinitis, n (%)

8 (47.1)

17 (47.2)

0.78

FSSG score

6.82 ± 6.48

8.75 ± 9.94

0.76

ACT score

22.4 ± 3.2

21.6 ± 3.7

0.31

ACQ-6

0.69 ± 0.83

1.09 ± 0.8

0.06

FeNO (ppb)

37.7 ± 28.3

40.9 ± 43.2

0.71

Peripheral neutrophil count, cells/µL

3603.5 ± 1468.4

4479.7 ± 2028.9

0.14

Peripheral eosinophil count, cells/µL

582.1 ± 1311.6

280.2 ± 218.0

0.57

Serum IgE level, IU/mL

583.6 ± 1359.5

603.84 ± 744.74

0.32

FVC, L

2.77 ± 0.62

2.84 ± 0.67

0.65

FVC, % of predicted

106.1 ± 15.7

96.7 ± 13.9

0.02

FEV1, L

2.0 ± 0.7

1.99 ± 0.59

0.8

FEV1, % of predicted

92.8 ± 19.1

82.4 ± 17.8

0.05

FEV1/FVC, %

72.1 ± 12.8

70.1 ± 11.9

0.58

MMF, L

1.5 ± 1.4

1.36 ± 0.87

0.92

MMF, % of predicted

51.8 ± 39.6

45.1 ± 25.4

0.46

Epworth Sleepiness Scale

6.35 ± 4.18

7.78 ± 4.83

0.27

Apnea Hypopnea Index

5.0 ± 3.2

21.7 ± 16.0

< 0.01

3% oxygen desaturation index

5.2 ± 3.1

22.2 ± 18.4

< 0.01

Lowest SpO2

86.9 ± 8.7

80.0 ± 8.5

< 0.01

  1. Data are presented as the mean ± standard deviation unless otherwise indicated BMI: body mass index, BNP: brain natriuretic peptide, GINA: global initiative for asthma, FSSG: frequency scale for the symptoms of gerd, ACT: asthma control test, ACQ: asthma control questionnaire, FeNO: fractional exhaled nitric oxide, IgE: imuunoglobulin E, FVC: forced vital capacity, FEV1: forced expiratory volume in one second, MMF: mid-maximal flow rate