Table 5 Comparison of patient characteristics by severity of OSA

Characteristics of asthma patients

Mild (n = 15)　　　

Moderate (n = 14)

Severe (n = 7)

P value

Male/Female, n (%)

4/11

4/10

3/4

0.98

Age, years

49.9 ± 16.1

60.1 ± 13.1

74.7 ± 10.4

< 0.01

Age at asthma onset, years

29.5 ± 22.45

44.2 ± 16.2

54.3 ± 25.6

0.06

BMI, kg/m²

27.9 ± 8.16

26.5 ± 4.9

31.0 ± 5.30

0.34

Smoking status: Never/Ex./Current, n (%)

8/5/2

7/3/4

2/3/2

0.95

Brinkman Index

178.9 ± 213.8

361.9 ± 455.9

381.1 ± 411.5

1

Hypertension, n (%)

5 (33.3)

5 (35.7)

6 (85.7)

0.14

Diabetes, n (%)

2 (13.3)

4 (28.6)

5 (71.4)

0.08

BNP, pg/ml

17.1 ± 15.1

54.1 ± 120.2

87.5 ± 98.0

< 0.01

GINA step (1/2/3/4/5), n (%)

0/1/4/6/4

0/0/3/8/3

0/0/2/5/0

0.95

Allergic rhinitis, n (%)

10 (66.7)

4 (28.6)

3 (42.9)

0.24

FSSG score

11.93 ± 12.12

7.21 ± 8.16

5.00 ± 6.43

0.24

ACT score

20.8 ± 4.5

21.6 ± 3.7

21.4 ± 3.6

0.98

ACQ-6

1.24 ±　1.1

2.33 ± 1.1

0.98 ± 0.72

0.96

FeNO (ppb)

42.4 ± 46.9

42.1 ± 46.2

34.8 ± 32.2

1

Peripheral neutrophil count, cells/µL

4738.0 ± 2389.4

4470.7 ± 1920.4

3944.3 ± 1483.0

0.8

Peripheral eosinophil count, cells/µL

257.1 ± 144.0

280.6 ± 208.9

328.8 ± 360.7

0.99

Serum IgE level, IU/mL

634.5 ± 755.2

384.35 ± 587.6

511.0 ± 623.2

0.09

FVC, L

3.11 ± 0.68

2.87 ± 0.48

2.17 ± 0.59

0.03

FVC, % of predicted

100.4 ± 14.2

101.8 ± 8.04

78.6 ± 6.38

< 0.01

FEV₁, L

2.30 ± 0.62

1.91 ± 0.36

1.47 ± 0.54

0.01

FEV₁, % of predicted

88.2 ± 19.2

84.3 ± 15.4

66.4 ± 9.00

0.01

FEV₁/FVC, %

74.0 ± 12.1

67.3 ± 10.3

67.6 ± 13.8

0.22

MMF, L

1.71 ± 0.97

1.17 ± 0.56

0.98 ± 0.98

0.06

MMF, % of predicted

51.7 ± 26.0

41.9 ± 21.3

37.2 ± 31.6

0.22

Epworth Sleepiness Scale

10.33 ± 5.29

6.79 ± 3.85

4.29 ± 2.43

0.01

Apnea Hypopnea Index

10.0 ± 3.38

21.3 ± 4.42

47.1 ± 16.4

< 0.01

3% oxygen desaturation index

9.2 ± 3.5

20.4 ± 4.7

53.6 ± 17.6

< 0.01

Lowest SpO₂

85.9 ± 2.9

80.1 ± 4.8

67.5 ± 8.1

< 0.01