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Table 3 Unadjusted secondary outcomes by intervention periods

From: Introduction of a penicillin allergy de-labelling program with direct oral challenge and its effects on utilization of beta-lactam antimicrobials: a multicenter retrospective parallel cohort study

 

Intervention (N = 174)

Non-intervention (N = 194)

Total (N = 368)

P-Value

OR (95% CI)

Penicillin allergy delabelling

 Patients delabeled 48 h from admission

23 (13.2%)

2 (1.0%)

25 (6.8%)

 < 0.001

14.63 (3.39–62.99)

 Patient delabeled 6 months from admission

26 (14.9%)

3 (1.5%)

29 (7.9%)

 < 0.001

11.18 (3.32–37.67)

Prescribing amongst all patients

 Beta-lactam use during admission

63 (36.2%)

64(34.0%)

129(35.1%)

0.91

1.10 (0.72–1.69)

 Beta-lactam use 6 months from admission

28 (16.1%)

15 (7.7%)

43 (11.7%)

0.04

2.29 (1.18–4.45)

 Non Beta-lactam use during admission

76 (43.7%)

65 (34.5%)

143 (38.9%)

0.2

1.47 (0.96–2.24)

 Non Beta-lactam use 6 months from admission

24 (14.4%)

29 (14.9%)

54 (14.7%)

0.99

0.95 (0.53–1.70)

Prescribing amongst those who received at least one antibiotic

 Beta-lactam use during admission

63 (55.75%)

64 (57.1%)

127 (56.4%)

0.98

1.49 (0.86–2.56)

 Non Beta-lactam use during admission

76 (67.3%)

65 (58.0%)

141 (62.7%)

0.36

0.95 (0.56–1.60)

 Non Beta-lactam use 6 months from admission

24 (52.2%)

29 (72.5%)

53 (61.6%)

0.15

0.41 (0.17–1.02)

C. difficile infection 3 months from admission

2 (1.1%)

4 (2.1%)

6 (1.6%)

0.79

0.55 (0.10–3.05)

Mean length of stay (SD)

6.93 (8.49)

7.74 (10.8)

7.35 (9.77)

0.42

NA

  1. Values are reported as counts (percentages) unless otherwise specified