Fig. 3

Down-regulation of circ_0070934 can promote apoptosis and affect the process of EMT in BEAS-2B cells. A BEAS-2B cells were divided into four groups: si-NC, si-circ_0070934, inhibitor NC and miR-199a-5p inhibitor. The level of cell apoptosis after transfection was quantified by Flow cytometry. B and C Western blot was used to detect the expression levels of epithelial-mesenchymal transition related molecular markers, including E-cadherin, N-cadherin and vimentin after transfection of si-NC or si-circ_0070934, and vector or circ_0070934 plasmid in BEAS-2B cells. The data were presented as mean ± SEM. Our experiments were repeated three times. ns, no significant; P > 0.05; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001