Fig. 4

MiR-199a-5p could reverse the effect of circ_0070934 on apoptosis and EMT of BEAS-2B cells. A BEAS-2B cells were divided into four groups: si-NC + inhibitor NC, si-circ_0070934 + inhibitor NC, si-circ_0070934 + miR-199a-5p inhibitor, si-NC + miR-199a-5p inhibitor. Flow cytometry was used to measure the level of cell apoptosis. B BEAS-2B cells were divided into three groups: si-NC + inhibitor NC, si-circ_0070934 + inhibitor NC, and si-circ_0070934 + miR-199a-5p inhibitor. The expression levels of proteins associated with EMT was detected by Western blot. C BEAS-2B cells were divided into three groups: vector + miR-NC, circ_0070934 + miR-NC, and circ_0070934 + miR-199a-5p mimics. Western blot was used to determine the expression levels of proteins associated with EMT. The data were presented as mean ± SEM. Our experiments were repeated three times. ns, no significant; P > 0.05; *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001