Articles

Review of the Manitoba cohort of patients with hereditary angioedema with normal C1 inhibitor

Hereditary angioedema with normal C1 inhibitor (HAE-nC1 INH) is a rare, underappreciated condition characterized by recurrent subcutaneous angioedema. The underlying pathophysiology and diagnostic criteria con...

Authors: Lundy McKibbin, Colin Barber, Chrystyna Kalicinsky and Richard Warrington

Gender differences in asthma perception and its impact on quality of life: a post hoc analysis of the PROXIMA (Patient Reported Outcomes and Xolair^® In the Management of Asthma) study

Gender differences in asthma perception and control have been reported. The PROXIMA observational study assessed these outcomes in a cohort of Italian severe allergic asthma (SAA) patients. This post hoc analy...

Authors: Delia Colombo, Emanuela Zagni, Fabio Ferri and Giorgio Walter Canonica

Differential expression of CCR2 and CX₃CR1 on CD16⁺ monocyte subsets is associated with asthma severity

Monocytes play an important role in immune and inflammatory diseases and monocyte subsets are predictors of disease in certain conditions. Expression of the chemokine receptors, CCR2 and CX₃CR1 on monocyte subset...

Authors: Reem Al-Rashoudi, Gillian Moir, Mohamed S. Al-Hajjaj, Monther M. Al-Alwan, Heather M. Wilson and Isabel J. Crane

Plasma cytokine profiles associated with rhodesiense sleeping sickness and falciparum malaria co-infection in North Eastern Uganda

Immunological Human African Trypanosomiasis (HAT) studies often exclude malaria, although both infections overlap in specific endemic areas. During this co-infection, it is not known whether this parasitic int...

Authors: Julius Nsubuga, Charles Drago Kato, Ann Nanteza, Enock Matovu and Vincent Pius Alibu

The association between caesarean section and childhood asthma: an updated systematic review and meta-analysis

Investigating the association between caesarean section (SC) and childhood asthma has shown contradictory results in different studies. The present study was conducted to determine the association between SC a...

Authors: Behzad Darabi, Shoboo Rahmati, Mohammad Reza HafeziAhmadi, Gholamreza Badfar and Milad Azami

CSACI position statement: Newer generation H₁-antihistamines are safer than first-generation H₁-antihistamines and should be the first-line antihistamines for the treatment of allergic rhinitis and urticaria

Oral H₁-antihistamines (AHs) are the most commonly used therapy to treat allergic rhinitis and chronic urticaria. Older, first-generation AHs (e.g. diphenhydramine, hydroxyzine) have significant and common side e...

Authors: Michael N. Fein, David A. Fischer, Andrew W. O’Keefe and Gord L. Sussman

Oral immunotherapy with peach juice in patients allergic to LTPs

To assess the safety and efficacy of an oral immunotherapy regimen in patients with allergy to lipid transfer proteins (LTPs).

Authors: Begoña Navarro, Eladia Alarcón, Ángela Claver, Mariona Pascal, Araceli Díaz-Perales and Anna Cisteró-Bahima

Haemopoietic stem cell transplantation in Systemic lupus erythematosus: a systematic review

Despite advances in treating Systemic lupus erythematosus (SLE), a proportion of patients continue to face significant morbidity and mortality. Haemopoietic stem cell transplant (HSCT) has been recognized as a...

Authors: Nipun Lakshitha de Silva and Suranjith L. Seneviratne

Serum IL-1β can be a biomarker in children with severe persistent allergic rhinitis

Allergic rhinitis (AR) is one of the most common diseases globally and usually persists throughout life. In the present study, we aimed to determine whether the expression of inflammatory biomarkers has a rela...

Authors: Myung Woul Han, Song Hee Kim, Inbo Oh, Yang Ho Kim and Jiho Lee

Maternal food allergy is associated with daughters’ menarche in early adolescence

Associations between allergic disease and puberty amongst females have been widely studied. However, this association has received less attention in multigenerational populations. To this end, we sought to exa...

Authors: Jennifer Lisa Penner Protudjer, Elissa Michelle Abrams, Anita Luba Kozyrskyj and Allan Barry Becker

Stress, pseudoallergens, autoimmunity, infection and inflammation in chronic spontaneous urticaria

Chronic spontaneous urticaria (CSU) is often associated with organ specific autoimmunity but is rarely caused by food allergy. Colourings and preservatives in pre-packaged foods, so called pseudoallergens, hav...

Authors: Ciara Jade Bansal and Amolak Singh Bansal

Successful management of severe asthma in a young boy with eosinophilic chronic rhinosinusitis who received omalizumab: a case report

The incidence of chronic rhinosinusitis with nasal polyps has recently increased in Japan and other East Asian countries, and this disease is called eosinophilic chronic sinusitis (ECRS) in Japan. ECRS usually...

Authors: Yasuho Shoda, Misa Watanabe, Kota Wada, Takehiko Soutome, Yumiko Komine, Tetsuo Mikami, Tetsuo Nemoto and Akira Ohara

Food allergy-related concerns during the transition to self-management

Compared to non-allergic individuals, food allergic individuals have impaired health-related quality of life (HRQL). However, effects of gender and age are unclear. The objective of our study was to describe a...

Authors: Jennifer Lisa Penner Protudjer, Roelinde Middelveld, Sven-Erik Dahlén and Staffan Ahlstedt

Efficacy of add-on mepolizumab in adolescents with severe eosinophilic asthma

Adolescents (12–17 years of age) with severe eosinophilic asthma experience frequent exacerbations and reduced lung function leading to poor health-related quality of life. Mepolizumab is approved for add-on m...

Authors: Steven W. Yancey, Hector G. Ortega, Oliver N. Keene and Eric S. Bradford

Shared prenatal impacts among childhood asthma, allergic rhinitis and atopic dermatitis: a population-based study

Increasing prevalence of childhood allergic diseases including asthma is a global health concern, and we aimed to investigate prenatal risk factors for childhood asthma and to address the potential shared pren...

Authors: Ching-Heng Lin, Jiun-Long Wang, Hsin-Hua Chen, Jeng-Yuan Hsu and Wen-Cheng Chao

Hypersensitivity reactions to high osmolality Total Parenteral Nutrition: a case report

The full range of allergic reactions to Total Parenteral Nutrition (TPN) remains unknown. Additionally, beyond individual allergens, there may be other factors contributing to TPN hypersensitivity reactions.

Authors: Steph A. Pang, Shaun Eintracht, Jesse M. Schwartz, Belinda Lobo and Elizabeth MacNamara

Structural alterations and markers of endothelial activation in pulmonary and bronchial arteries in fatal asthma

There is interest in better understanding vessel pathology in asthma, given the findings of loss of peripheral vasculature associated with disease severity by imaging and altered markers of endothelial activat...

Authors: Renata Calciolari Rossi, Raquel Anonni, Diogenes Seraphim Ferreira, Luiz Fernando Ferraz da Silva and Thais Mauad

Subcutaneous C1 inhibitor for prevention of attacks of hereditary angioedema: additional outcomes and subgroup analysis of a placebo-controlled randomized study

Hereditary angioedema (HAE) is a debilitating disorder resulting from C1-esterase inhibitor (C1-INH) deficiency. In the COMPACT phase 3 study the prophylactic use of a subcutaneous C1 inhibitor (C1-INH [SC], H...

Authors: H. Henry Li, Bruce Zuraw, Hilary J. Longhurst, Marco Cicardi, Konrad Bork, James Baker, William Lumry, Jonathan Bernstein, Michael Manning, Donald Levy, Marc A. Riedl, Henrike Feuersenger, Subhransu Prusty, Ingo Pragst, Thomas Machnig and Timothy Craig

Short-term pulmonary infiltrate with eosinophilia caused by asthma: a phenotype of severe, eosinophilic asthma? Five cases and a review of the literature

Asthma is often accompanied by peripheral eosinophilia and eosinophilic airway inflammation. This article explores the relationship between asthma and short-term pulmonary infiltrate with eosinophilia, which r...

Authors: Min Song, Shan Cai, Hong Luo, Yi Jiang, Min Yang, Yan Zhang, Hong Peng and Ping Chen

Graft versus host disease and microchimerism in a JAK3 deficient patient

The lymphohematopoietic cells originating from feto-maternal trafficking during pregnancy may cause microchimerism and lead to materno-fetal graft versus host disease (GVHD) in severe combined immunodeficiency...

Authors: Zahra Shahbazi, Nima Parvaneh, Shirin Shahbazi, Hamzeh Rahimi, Mohammad Hamid, Davoud Shahbazi, Samaneh Delavari, Hassan Abolhassani, Asghar Aghamohammadi and Reza Mahdian

Sestrin2 is involved in asthma: a case–control study

Asthma is a chronic disease that seriously harms the health of patients. Oxidative stress is involved in asthma. As an oxidative stress-inducible protein, sestrin2 is elevated in oxidative stress-related disea...

Authors: Yanfang Kang, Chen Chen, Xiaotian Hu, Xiaohua Du, Huifen Zhai, Yan Fang, Xiulin Ye, Weimin Yang and Shibo Sun

Abstracts of 11th C1-inhibitor Deficiency & Angioedema Workshop

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Endogenous stimulation is responsible for the high frequency of IL-17A-producing neutrophils in patients with rheumatoid arthritis

Neutrophils play an important role in the pathogenesis of rheumatoid arthritis (RA). It has recently been reported that in addition to T helper (Th) 17 cells, other cells, including neutrophils, produce IL-17A...

Authors: Maria Gonzalez-Orozco, Rosa E. Barbosa-Cobos, Paola Santana-Sanchez, Lizbeth Becerril-Mendoza, Leonardo Limon-Camacho, Ana I. Juarez-Estrada, Gustavo E. Lugo-Zamudio, Jose Moreno-Rodriguez and Vianney Ortiz-Navarrete

Epigenome-wide association study of asthma and wheeze characterizes loci within HK1

To identify novel epigenetic markers of adolescent asthma and replicate findings in an independent cohort, then explore whether such markers are detectable at birth, predictive of early-life wheeze, and associ...

Authors: Todd M. Everson, Hongmei Zhang, Gabrielle A. Lockett, Akhilesh Kaushal, Melinda Forthofer, Susan L. Ewart, Kimberley Burrows, Caroline L. Relton, Gemma C. Sharp, A. John Henderson, Veeresh K. Patil, Faisal I. Rezwan, S. Hasan Arshad, John W. Holloway and Wilfried Karmaus

Allergen sensitization pattern of allergic adults and children in southern China: a survey based on real life data

Allergic diseases are increasing yearly. We aimed to evaluate the difference in allergen sensitization pattern between adults and children in southern China by analyzing a large sample size of real-life data, ...

Authors: Wenting Luo, Haisheng Hu, Wangbing Tang, Xiangwei Zou, Huimin Huang, Zhifeng Huang, Yong Liu and Baoqing Sun

Clinical and pulmonary function changes in cough variant asthma with small airway disease

It is known that small airway disease is present across all asthma severities; however, its prevalence and clinical characteristics in cough variant asthma (CVA) have not been fully illuminated.

Authors: Honglei Yuan, Xiaojing Liu, Li Li, Gang Wang, Chunfang Liu, Yuzhen Zeng, Ruolin Mao, Chunling Du and Zhihong Chen

Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2018: Part Two

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Maternal diet before and during pregnancy and risk of asthma and allergic rhinitis in children

Consumption of certain foods during pregnancy has been shown to have beneficial effects on childhood asthma and allergic disease development and aggravation. However, most studies provide conflicting results a...

Authors: Nour Baïz, Jocelyne Just, Julie Chastang, Anne Forhan, Blandine de Lauzon-Guillain, Anne-Marie Magnier and Isabella Annesi-Maesano

Inflammatory patterns of antrochoanal polyps in the pediatric age group

The pathogenesis and etiology of antrochoanal polyps (ACPs) remains obscure. This study aimed to characterize the inflammatory profiles and investigate the effect of atopy on the pathogenesis of pediatric ACPs.

Authors: Huiwen Zheng, Lixing Tang, Beibei Song, Xiaojian Yang, Ping Chu, Shujing Han, Pengpeng Wang, Jie Lu, Wentong Ge and Xin Ni

Risk factors and prognosis of recurrent wheezing in Chinese young children: a prospective cohort study

Nearly all the investigations into the risk factors for wheezing and asthma were conducted in developed countries with a high prevalence rate of asthma and allergy, but the studies in developing countries are ...

Authors: Jing Guo, Wenjing Zhu, Huimin Wang, Patrick G. Holt, Guicheng Zhang and Chuanhe Liu

Outcomes following mepolizumab treatment discontinuation: real-world experience from an open-label trial

Limited information is available on the clinical course of patients with severe asthma following discontinuation of biologic treatment. Therefore, a post hoc analysis was conducted in patients with severe eosi...

Authors: Hector Ortega, Catherine Lemiere, Jean-Pierre Llanos, Mark Forshag, Robert Price, Frank Albers, Steven Yancey and Mario Castro

Sinobronchial allergic mycosis syndrome in an elderly male

Allergic bronchopulmonary aspergillosis (ABPA) and allergic fungal rhinosinusitis (AFRS) are characterized by hyper-responsiveness of the respiratory tract and the nasal cavity and paranasal sinuses, respectiv...

Authors: Eisuke Mochizuki, Shun Matsuura, Tsutomu Kubota, Yasutaka Mochizuka, Kyohei Oishi, Hyogo Naoi, Masahiro Uehara, Shinichiro Mikura, Miyuki Nagaoka, Masaru Tsukui, Naoki Koshimizu and Ichirota Nameki

Chronic idiopathic systemic capillary leak syndrome: a case report

Idiopathic systemic capillary leak syndrome (ISCLS), is a rare disorder characterized by recurrent attacks of varying severity of hypovolemic shock and generalized edema in association with hemoconcentration a...

Authors: Ahmed M. Alkhunaizi, Abdullah H. Kabbani and Mohamed A. ElTigani

Pleiotropic microRNA-21 in pulmonary remodeling: novel insights for molecular mechanism and present advancements

MicroRNA-21 (miR-21), probably one of the most studied miRNAs to date, is found pleiotropic in various biological events. Its emerging role in pulmonary remodeling has attracted extensive attention. This revie...

Authors: Congshan Jiang, Yuanxu Guo, Hongchuan Yu, Shemin Lu and Liesu Meng

Genotype-first analysis of a generally healthy population cohort supports genetic testing for diagnosis of hereditary angioedema of unknown cause

Hereditary angioedema (HAE) is a potentially life-threatening group of conditions that is often underdiagnosed or misdiagnosed. As HAE is typically diagnosed by detecting C1 inhibitor deficiency, there is a cr...

Authors: Dale L. Bodian, Thierry Vilboux and Natalie S. Hauser

Health effects of diesel engine exhaust emissions exposure (DEEE) can mimic allergic asthma and rhinitis

Patients presenting to Accident and Emergency (A&E) facilities with dyspnoea, coughing, wheezing and nasal blockage are presumed to have allergic asthma and/or rhinitis. Occupational asthma (OA), which has sim...

Authors: Elopy Sibanda and Nancy Makaza

Stability of peripheral blood immune markers in patients with asthma

Asthma is a complex disease with variable course. Efforts to identify biomarkers to predict asthma severity, the course of disease and response to treatment have not been very successful so far. We have previo...

Authors: Nami Shrestha Palikhe, Ana-Maria Bosonea, Cheryl Laratta, Vivek Dipak Gandhi, Drew Nahirney, Angela Hillaby, Miranda Bowen, Mohit Bhutani, Irvin Mayers, Lisa Cameron and Harissios Vliagoftis

Association of molds and metrological parameters to frequency of severe asthma exacerbation

Sensitization to airborne molds may be a risk factor for severe asthma and direct cause of asthma exacerbation (AE).

Authors: Mona Al-Ahmad, Edin Jusufovic, Nermina Arifhodzic, Tito Rodriguez and Jasmina Nurkic

Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population

Asthma is a complex disorder with multiple phenotypes which can influence its severity and response to treatment. The T_H17 lymphocytes producing IL-17A and IL17-F cytokines, may have a role on asthma inflammation...

Authors: Milca de J. Silva, Maria B. R. de Santana, Bruna R. Tosta, Roberta P. Espinheira, Neuza Maria Alcantara-Neves, Maurício L. Barreto, Camila Alexandrina Figueiredo and Ryan dos S. Costa

Sublingual immunotherapy tablet for the treatment of house dust mite allergic rhinitis in Canada: an alternative to minimize treatment costs?

A cost-minimization analysis (CMA) was performed to estimate the economic impact of introducing the SQ house dust mite sublingual immunotherapy (SQ HDM SLIT)-tablet marketed as ACARIZAX™ (regulatory approval M...

Authors: Anne K. Ellis, Rémi Gagnon, Eva Hammerby and Andrea Lau

Evaluation of eczema, asthma, allergic rhinitis and allergies among the grade-7 children of Iqaluit

Little is known about the prevalence of asthma, allergic rhinitis, eczema and allergies among Canadian Inuit children, especially those living in the arctic and subarctic areas.

Authors: Ahmed Ahmed and Allan Becker

Autoimmune thyroid disease and urticarial vasculitis: is there a significant association?

Little is known about the association of urticarial vasculitis (UV) with thyroid autoimmunity. The latter has been mostly described in the setting of patients with chronic spontaneous urticaria (CSU). In this ...

Authors: Ivan Cherrez-Ojeda, Emanuel Vanegas, Valeria L. Mata, Miguel Felix, German D. Ramon, Sofia Cherrez and Annia Cherrez

The complex pathophysiology of allergic rhinitis: scientific rationale for the development of an alternative treatment option

Allergic rhinitis (AR) poses a global health problem and can be challenging to treat. Many of the current symptomatic treatments for AR have been available for decades, yet there has been little improvement in...

Authors: Leif Bjermer, Marit Westman, Mats Holmström and Magnus C. Wickman

Enhanced interleukin-8 production in mononuclear cells in severe pediatric obstructive sleep apnea

Obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease, metabolic disorders, and cognitive dysfunction. Current thinking links chronic intermittent hypoxia (CIH) with oxidative stress and sy...

Authors: Danbing Ke, Yuji Kitamura, Duncan Lejtenyi, Bruce Mazer, Robert T. Brouillette and Karen Brown

Correction to: Eosinophilic esophagitis

Eosinophilic esophagitis (EoE) is an atopic condition of the esophagus that has become increasingly recognized over the last 15 years. Diagnosis of the disorder is dependent on the patient’s clinical manifesta...

Authors: Stuart Carr, Edmond S. Chan and Wade Watson

Proceedings of AllerGen 2019 Research Conference

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Omalizumab in patients with severe asthma and persistent sputum eosinophilia

Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics, who remain uncontrolled despite high dose inhaled ...

Authors: Manali Mukherjee, Melanie Kjarsgaard, Katherine Radford, Chynna Huang, Richard Leigh, Delbert R. Dorscheid, Catherine Lemiere, Louis-Philippe Boulet, Susan Waserman, James Martin and Parameswaran Nair

Variability in total serum IgE over 1 year in severe asthmatics

Immunoglobulin E (IgE) is the treatment target of omalizumab, a monoclonal antibody indicated in the treatment of severe allergic asthma. Long-term variability of serum total IgE (sIgE_tot) in asthmatics remains p...

Authors: Renaud Louis, Charles Pilette, Olivier Michel, Alain Michils, Guy Brusselle, Antoine Poskin, Jan Van Schoor, Kris Denhaerynck, Stefaan Vancayzeele, Ivo Abraham and Sandra Gurdain

Severe anaphylaxis after pelvic examination: a case report of dual latex and chlorhexidine allergies

Natural rubber latex and chlorhexidine have previously been identified as causative substances in perioperative anaphylaxis. A pelvic examinations is generally considered noninvasive, however, this procedure i...

Authors: Mongkhon Sompornrattanaphan, Piyawut Kreetapirom, Yuttana Srinoulprasert, Duangjit Kanistanon, Anchalika Klinniyom, Chamard Wongsa and Torpong Thongngarm

Pruritus in patients with amyopathic dermatomyositis

Amyopathic dermatomyositis has been associated with the exposure to several drugs: the article by Jeimy et al. described the onset of this uncommon disease in a patient treated with omalizumab. Paradoxically, ...

Authors: Dimitri Poddighe, Zaure Mukusheva and Maikesh Assylbekova