Articles

Adjunct therapy with probiotics for chronic urticaria in children: randomised placebo-controlled trial

Chronic urticaria is a common disorder of the skin, characterised by recurrent skin wheals and angioedema. Recent reports have shown that altered diversity and composition of the gut microbiota may lead to imb...

Authors: Xiao-Dong Bi, Bao-Zhen Lu, Xin-Xin Pan, Sha Liu and Jiu-Yao Wang

Interleukin-35 inhibited the production of histamine and pro-inflammatory cytokines through suppression MAPKs pathway in HMC-1 cells

IL-35 is a newly anti-inflammatory cytokine that belongs to the IL-12 family. Mast cells, as one of the major effector cells in the immune response system, plays an important role in the pathogenesis of chroni...

Authors: Li-xin Fu, Tao Chen, Qiao-mei Sun, Pei-mei Zhou and Zai-pei Guo

DRESS induced by amoxicillin-clavulanate in two pediatric patients confirmed by lymphocyte toxicity assay

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare but serious delayed hypersensitivity reaction that can be caused by antibiotic exposure. The reaction typically develops in 2 to 6 weeks....

Authors: Arun Dhir, Hasandeep Kular, Abdelbaset A. Elzagallaai, Bruce Carleton, Michael J. Rieder, Raymond Mak and Tiffany Wong

A case of hand urticaria, lip angioedema, and oropharyngeal pruritus induced by Japanese radish through IgE-mediated immediate allergic reaction

Although Japanese radish (Raphanus sativus L.) is a common Japanese ingredient, there are few reports of IgE-mediated immediate food allergy caused by Japanese radish.

Authors: Sumiko Abe, Jun Ito, Sonoko Harada, Hitoshi Sasano, Shoko Ueda, Yuuki Sandhu, Tomohito Takeshige, Yoko Katsura, Norihiro Harada and Kazuhisa Takahashi

Autoantibodies to speckled protein family in primary biliary cholangitis

The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients. One of the two immunofl...

Authors: Alessandro Granito, Luigi Muratori, Francesco Tovoli and Paolo Muratori

Proceedings of the Canadian Society of Allergy and Clinical Immunology Annual Scientific Meeting 2020

Authors:

Clinical validation of controlled exposure to house dust mite in the environmental exposure unit (EEU)

The Environmental Exposure Unit (EEU), a controlled allergen exposure model of allergic rhinitis (AR), has traditionally utilized seasonal allergens. We sought to clinically validate the use of house dust mite...

Authors: Lubnaa Hossenbaccus, Sophia Linton, Jenny Thiele, Lisa Steacy, Terry Walker, Crystal Malone and Anne K. Ellis

The effect of Co-Q10 on allergic rhinitis and allergic asthma

Allergic asthma is an inflammatory disease resulting from continued or intermittent allergen exposure, and allergic rhinitis can be trigger of asthma. The main mechanism of these disease is allergic reaction a...

Authors: Qixue Du, Wei Meng, Seyyed Shamsadin Athari and Renzhong Wang

Practical challenges in oral immunotherapy resolved through patient-centered care

Oral immunotherapy (OIT) is now widely recognized as a valid option for the management of IgE-mediated food allergies. However, in real-life practice, OIT can lead to a variety of unique situations where the b...

Authors: François Graham, Douglas P. Mack and Philippe Bégin

Early intervention of atopic dermatitis as a preventive strategy for progression of food allergy

Atopic diseases, such as atopic dermatitis (AD) and food allergy (FA), have increased in prevalence in industrialized countries during the past few decades and pose a significant health burden. They appear to ...

Authors: Alyssa Sweeney, Vanitha Sampath and Kari C. Nadeau

COVID-19 vaccine testing & administration guidance for allergists/immunologists from the Canadian Society of Allergy and Clinical Immunology (CSACI)

Safe and effective vaccines provide the first hope for mitigating the devastating health and economic impacts resulting from coronavirus disease 2019 (COVID-19) and related public health orders. Recent case re...

Authors: Timothy K. Vander Leek, Edmond S. Chan, Lori Connors, Beata Derfalvi, Anne K. Ellis, Julia E. M. Upton and Elissa M. Abrams

The excess costs of childhood food allergy on Canadian families: a cross-sectional study

The impact of childhood food allergy on household costs has not been examined in Canada. The current study sought to examine differences in direct, indirect, and intangible costs among Canadian families with a...

Authors: Michael A. Golding, Elinor Simons, Elissa M. Abrams, Jennifer Gerdts and Jennifer L. P. Protudjer

Prevalence of adult eczema, hay fever, and asthma, and associated risk factors: a population-based study in the northern Grassland of China

There has been research about the prevalence and risk factors of eczema, hay fever, and asthma in children, but little is known about these conditions in adults in China.

Authors: Xiaoyan Wang, Yan Zhuang, Yanlei Chen, Hongtian Wang and Xueyan Wang

Content analysis of promotional material for asthma-related products and therapies on Instagram

Increasingly, social media is a source for information about health and disease self-management. We conducted a content analysis of promotional asthma-related posts on Instagram to understand whether promoted ...

Authors: Brent Heineman, Marcella Jewell, Michael Moran, Kolbi Bradley, Kerry A. Spitzer and Peter K. Lindenauer

The pharmacokinetics of epinephrine/adrenaline autoinjectors

For a century, epinephrine has been the drug of choice for acute treatment of systemic allergic reactions/anaphylaxis. For 40 years, autoinjectors have been used for the treatment of anaphylaxis. Over the last...

Authors: Sten Dreborg and Harold Kim

MicroRNA-29 mediates anti-inflammatory effects and alleviation of allergic responses and symptoms in mice with allergic rhinitis

To investigate the role of microRNA-29 (miR-29) in mice with allergic rhinitis (AR) and its underlying mechanism.

Authors: Jia Wang, Jinshu Yin, Hong Peng and Aizhu Liu

Non-association between low vitamin d levels and aeroallergen-positivity evaluated using multiple allergen simultaneous test in Korean adults

Studies on the association between vitamin D levels and allergen sensitization have reported conflicting results. We aimed to evaluate the association between low vitamin D levels and sensitization to 59 aeroa...

Authors: Jee Hye Wee, Sung Woo Cho, Jeong-Whun Kim and Chae-Seo Rhee

Effects of a 90-min educational intervention for patients with insect venom allergy: a prospective controlled pilot study

Anaphylactic sting reactions need a prompt management. A structured educational intervention for patients with insect sting allergy has not been implemented so far. The purpose of this study was to analyze the...

Authors: Lisa-Sophie Schoeben, Nicole Mohr, Corinna Bubak, Astrid Schmieder and Marthe-Lisa Schaarschmidt

Associations of sleep characteristics with atopic disease: a cross-sectional study among Chinese adolescents

Adolescence, as a transition between childhood and adulthood, is a critical stage for the long-term control of atopic diseases. We aim to determine if sleep characteristics are involved in the increased risk o...

Authors: Yiting Chen, Qian Yang, Kena Zhao, Zengqiang Wu, Xiaoming Shen and Shenghui Li

Clinical characteristics and risk factors for cefaclor-induced immediate hypersensitivity: a retrospective observation at two university hospitals in Korea

Cefaclor, a second-generation oral cephalosporin, is widely prescribed to treat infectious diseases. Immediate hypersensitivity (HS) reactions to cefaclor have continuously been reported and are expected to in...

Authors: Hyo-In Rhyou, Go-Eun Doo, Jiwon Yoon, Chae-Yeon Ha, Hee-Joo Nam, Sung-Dae Woo, Youngsoo Lee, Young-Hee Nam and Young-Min Ye

Community-based interventions for childhood asthma using comprehensive approaches: a systematic review and meta-analysis

We conducted a systematic review and meta-analysis to determine the effectiveness of comprehensive community-based interventions with ≥ 2 components in improving asthma outcomes in children.

Authors: Mei Chan, Melinda Gray, Christine Burns, Louisa Owens, Susan Woolfenden, Raghu Lingam, Adam Jaffe and Nusrat Homaira

Effectiveness of C1-INH therapy in angiotensin converting enzyme inhibitor induced angioedema

Angiotensin Converting Enzyme Inhibitors (ACEI) are a common cause of Emergency Room presentation for angioedema. Although no treatment guidelines exist, C1 esterase inhibitor concentrate (C1-INH) is used on a...

Authors: Uliana Kovaltchouk, Boyang Zhang, Vipul Jain and Chrystyna Kalicinsky

Clonal expansion of CD4⁺CD8⁺ T cells in an adult patient with Mycoplasma pneumoniae-associated Erythema multiforme majus

Erythema multiforme (EM) is an acute, immune-mediated mucocutaneous disease, most often preceded by herpes simplex virus (HSV) infection or reactivation. Mycoplasma pneumoniae (Mp) is considered the second major ...

Authors: Sarah M. Volkers, Christian Meisel, Dorothea Terhorst-Molawi, Guido J. Burbach, Dirk Schürmann, Norbert Suttorp and Leif E. Sander

Can eosinophilia and neutrophil–lymphocyte ratio predict hospitalization in asthma exacerbation?

Asthma is one of the most common diseases amongst children. Blood eosinophil count and neutrophil–lymphocyte ratio (NLR) are known as markers for phenotyping asthma. This study was performed to investigate blo...

Authors: Hossein Esmaeilzadeh, Fatemeh Nouri, Seyed Hesamodin Nabavizadeh, Soheila Alyasin and Negar Mortazavi

Fixed drug eruption and anaphylaxis induced concurrently by erdosteine: a case report

Erdosteine is used as a mucolytic agent and has a low incidence of adverse drug reactions, most of which are gastrointestinal and mild. Moreover, drug antigens rarely induce multiple simultaneous immunologic r...

Authors: Da Woon Sim, Ji Eun Yu and Young-Il Koh

Rapid clinical recovery of a SARS-CoV-2 infected common variable immunodeficiency patient following the infusion of COVID-19 convalescent plasma

Common variable immunodeficiency is the most prevalent symptomatic primary immunodeficiency in adults. Affected patients fail to mount an appropriate humoral response against community acquired infectious dise...

Authors: Luciana C. Ribeiro, Bruno Deltreggia Benites, Raisa G. Ulaf, Thyago A. Nunes, Carolina Costa-Lima, Marcelo Addas-Carvalho, José Luiz Proenca-Modena, Fabiana Granja, Vitor Antonio da Costa, Adriana da Silva Santos Duarte, Audrey Basso Zangirolami, Emerson Clayton Amaro, Eli Mansour, Ricardo L. Zollner and Licio A. Velloso

Comprehensive analysis of allergen-specific IgE in COPD: mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap

Although the relationship between allergic sensitization and increased respiratory symptoms of chronic obstructive pulmonary disease (COPD) has been suggested, which allergen has a significant effect on COPD p...

Authors: Hikaru Toyota, Naoya Sugimoto, Konomi Kobayashi, Yuki Suzuki, Yuri Takeshita, Ayaka Ito, Mariko Ujino, Fuminori Tomyo, Hirokazu Sakasegawa, Yuta Koizumi, Michio Kuramochi, Masao Yamaguchi and Hiroyuki Nagase

Mothers of children with food allergies report poorer perceived life status which may be explained by limited career choices

Pediatric food allergy is associated with direct, indirect and intangible costs. However, it remains unclear if intangible costs of pediatric food allergy influence parental career choices. Using data from 63 ...

Authors: Tara Lynn Mary Frykas, Michael Golding, Elissa M. Abrams, Elinor Simons and Jennifer Lisa Penner Protudjer

Long-term outcomes of 0.1% tacrolimus eye drops in eyes with severe allergic conjunctival diseases

Because atopic dermatitis does not heal completely, associated severe atopic keratoconjunctivitis (AKC) and vernal keratoconjunctivitis (VKC) often require long-term treatment. This study aims to evaluate the ...

Authors: Hiroyuki Yazu, Kazumi Fukagawa, Eisuke Shimizu, Yasunori Sato and Hiroshi Fujishima

Impact of Polyvalent Mechanical Bacterial Lysate on lymphocyte number and activity in asthmatic children: a randomized controlled trial

Polyvalent Mechanical Bacterial Lysate (PMBL®) contains antigens of bacteria responsible for respiratory infections. PMBL® has been proven to reduce the number of respiratory infections, and in its use, immuno...

Authors: Małgorzata Bartkowiak-Emeryk, Andrzej Emeryk, Jacek Roliński, Ewelina Wawryk-Gawda and Ewa Markut-Miotła

Exome sequencing enables diagnosis of X-linked hypohidrotic ectodermal dysplasia in patient with eosinophilic esophagitis and severe atopy

X-linked hypohidrotic ectodermal dysplasia (XLHED) is the most common form of ectodermal dysplasia. Clinical and genetic heterogeneity between different ectodermal dysplasia types and evidence of incomplete pe...

Authors: Bhavi P. Modi, Kate L. Del Bel, Susan Lin, Mehul Sharma, Phillip A. Richmond, Clara D. M. van Karnebeek, Edmond S. Chan, Vishal Avinashi, Wingfield E. Rehmus, Catherine M. Biggs, Wyeth W. Wasserman and Stuart E. Turvey

Melkersson–Rosenthal syndrome misdiagnosed as recurrent Bell’s palsy: a case report and review of literature

Melkersson–Rosenthal syndrome (MRS) is a rare neuro-mucocutaneous disorder of unknown cause, clinically characterized by a triad of recurrent facial palsy, orofacial swelling, and fissured tongue. It is freque...

Authors: Yared Zenebe Zewde

Bidirectional association between asthma and otitis media in children

This study explored the reciprocal association between otitis media and asthma in children.

Authors: So Young Kim, Hye-Rim Kim, Chanyang Min and Hyo Geun Choi

Three cases of BRAF mutation negative Erdheim-Chester disease with a challenging distinction from IgG4-related disease

Erdheim-Chester disease (ECD) is a rare non-Langerhans histiocytosis with slow progression over the years that is particularly difficult to diagnose.

Authors: David Spoerl, Raphaël André, Aurélie Bornand and Jörg D. Seebach

Asthma and COVID-19: a systematic review

Severe coronavirus disease-19 (COVID-19) presents with progressive dyspnea, which results from acute lung inflammatory edema leading to hypoxia. As with other infectious diseases that affect the respiratory tr...

Authors: Natália F. Mendes, Carlos P. Jara, Eli Mansour, Eliana P. Araújo and Licio A. Velloso

Relationship between Th17-mediated immunity and airway inflammation in childhood neutrophilic asthma

The pathogenetic mechanisms of neutrophilic asthma are not well understood now. Whether T helper (Th)17-mediated immunity contributes to the pathogenesis of neutrophilic asthma in human is still under investig...

Authors: Qing Wei, Jing Liao, Min Jiang, Jing Liu, Xiuan Liang and Guangmin Nong

Targeting the IL-5 pathway in eosinophilic asthma: a comparison of mepolizumab to benralizumab in the reduction of peripheral eosinophil counts

Mepolizumab and benralizumab are biologics approved for severe eosinophilic asthma. Mepolizumab is an anti-interlukin-5 (IL-5) antibody while benralizumab is an anti-interleukin-5 receptor alpha (IL-5Rα) antib...

Authors: Arian Ghassemian, Jane Jiyoon Park, Michael W. Tsoulis and Harold Kim

Successful sublingual immunotherapy for severe egg allergy in children: a case report

Egg allergy is one of the most common food allergies in children. To date, oral immunotherapy (OIT) has been considered as a promising treatment option for egg allergy. However, safety issues remain concerning...

Authors: Nagatoshi Sagara, Satoshi Fujita, Ryohei Suzuki, Akiko Aota, Kenichi Akashi and Toshio Katsunuma

Catechin synergistically potentiates mast cell-stabilizing property of caffeine

Caffeine and catechin, contained in coffee and tea, are commonly consumed substances worldwide. Studies revealed their health promoting functions, such as anti-oxidant, anti-cancer and anti-bacterial propertie...

Authors: Misaki Yashima, Yukine Sato and Itsuro Kazama

First pediatric electronic algorithm to stratify risk of penicillin allergy

Beta-lactam allergy is reported in 5–10% of children in North America, but up to 94–97% of patients are deemed not allergic after allergist assessment. The utility of standardized skin testing for penicillin a...

Authors: Hannah Roberts, Lianne Soller, Karen Ng, Edmond S. Chan, Ashley Roberts, Kristopher Kang, Kyla J. Hildebrand and Tiffany Wong

Predominant patterns of β-lactam hypersensitivity in a single German Allergy Center: exanthem induced by aminopenicillins, anaphylaxis by cephalosporins

Penicillins and other β-lactam antibiotics are the most common elicitors of allergic drug reaction. However, data on the pattern of clinical reaction types elicited by specific β-lactams are scarce and inconsi...

Authors: Philipp Schrüfer, Knut Brockow, Johanna Stoevesandt and Axel Trautmann

Hypersensitivity reactions after femtosecond laser small incision lenticule extraction: a case report of corneal infiltrates

Femtosecond laser corneal refractive surgery is generally considered safe and effective; however, this procedure is rarely associated with severe allergic reactions. We reported a rare case of hypersensitivity...

Authors: Jiaonan Ma, Lin Zhang, Mengdi Li and Yan Wang

Successful olaparib desensitization using a novel one-day protocol

Olaparib is a revolutionary treatment for patients with ovarian and breast cancer. Currently, there is no established 1-day drug desensitization protocol for patients with olaparib type-1 hypersensitivity reac...

Authors: Rongbo Zhu, Stephen Welch and Hannah Roberts

Adults with possible food protein-induced enterocolitis syndrome with crustacean ingestion

Food protein-induced enterocolitis (FPIES), an entity previously thought to only affect children, has been increasingly described in adults. In this study, we report a Canadian cohort of 19 adolescents and adu...

Authors: Daniel H. Li, Andrew Wong-Pack, Andrea Leilani Macikunas and Harold Kim

Prevalence of allergic rhinitis, related comorbidities and risk factors in schoolchildren

The study aimed to determine the prevalence and risk factors of allergic rhinitis and related comorbidities in school-age children in Budapest, capital of Hungary. Data and epidemiological studies on this dise...

Authors: Monika Sultész, Alpár Horváth, Dávid Molnár, Gábor Katona, Györgyi Mezei, Andor Hirschberg and Gabriella Gálffy

Refractory chronic urticaria in adults: clinical characterization and predictors of severity

Chronic urticaria (CU) is defined as recurrent urticaria lasting for more than 6 weeks.

Authors: Iolanda Alen Coutinho, Frederico Soares Regateiro, Rosa Anita Fernandes, Joana Sofia Pita, Raquel Gomes, Constança Coelho and Ana Todo Bom

Review of icatibant use in the Winnipeg Regional Health Authority

This is a retrospective review of the Winnipeg Regional Health Authority’s (WRHA) angioedema patients who were dispensed icatibant in hospital. Icatibant is a bradykinin B2 receptor antagonist indicated for He...

Authors: George Cai, Colin Barber and Chrystyna Kalicinsky

Practical guide for evaluation and management of beta-lactam allergy: position statement from the Canadian Society of Allergy and Clinical Immunology

The vast majority of individuals labelled as allergic are not deemed truly allergic upon appropriate assessment by an allergist. A label of beta-lactam allergy carries important risks for individual and public...

Authors: Samira Jeimy, Moshe Ben-Shoshan, Elissa M. Abrams, Anne K. Ellis, Lori Connors and Tiffany Wong

Association between asthma and invasive pneumococcal disease risk: a systematic review and meta-analysis

Asthma has been shown to be related to an increased risk of invasive pneumococcal disease (IPD), although the results remain inconclusive. Therefore, we performed a meta-analysis to determine whether asthma in...

Authors: Lingling Li, Yusheng Cheng, Xiongwen Tu, Jie Yang, Chenghui Wang, Min Zhang and Zhiwei Lu

Non-allergic severe asthma: is it really always non-allergic? The IDENTIFY project

This differential diagnosis of allergic vs non-allergic asthma is typically made on the basis of sensitization to allergens, such that absence of sensitization could result in a patient being managed as having...

Authors: Dirk Koschel, Claudia Mailänder, Inessa Schwab Sauerbeck and Jens Schreiber