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  1. The COVID-19 pandemic has highlighted disparities in healthcare, particularly in the United States, even though disparities have existed since the organization of the modern healthcare system. Recruitment of p...

    Authors: Timothy J. Craig, Rafael H. Zaragoza-Urdaz, H. Henry Li, Ming Yu, Hong Ren, Salomé Juethner and John Anderson
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:85
    Content type: Short report Published on:

  2. Hereditary angioedema (HAE) is an inherited disease characterized by recurrent angioedema without urticaria or pruritus. The most common types of HAE are caused by deficiency or dysfunction in C1 esterase inhi...

    Authors: Yusuke Ushio, Risa Wakiya, Tomohiro Kameda, Shusaku Nakashima, Hiromi Shimada, Mai Mahmoud Fahmy Mansour, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Rina Mino, Mao Mizusaki, Emi Ibuki, Norimitsu Kadowaki and Hiroaki Dobashi
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:84
    Content type: Case report Published on:

  3. Reports of allergic reactions to the COVID-19 vaccines have been documented, which may also contribute to hesitancy. Despite the low likelihood that the COVID-19 vaccine will trigger an allergic reaction, we a...

    Authors: Michael A. Golding, Nicole Askin, Ayel Luis R. Batac, Kaitlyn A. Merrill, Elissa M. Abrams, Philippe Bégin, Moshe Ben-Shoshan, Erika Ladouceur, Leslie E. Roos, Vladan Protudjer and Jennifer L. P. Protudjer
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:83
    Content type: Research Published on:

  4. Anti-interferon-gamma autoantibody-associated immunodeficiency syndrome is a rare and underrecognized adult onset immunodeficiency syndrome associated with severe opportunistic infections such as disseminated ...

    Authors: Spencer Boyle, Ashley Hagiya, Minh-Vu H. Nguyen, Howard Liebman and Jin Sol G. Lee
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:82
    Content type: Case report Published on:

  6. COVID-19 presents with a variable clinical course from asymptomatic to severe respiratory distress with nearly 25% mortality in mechanically-ventilated patients. As such, there is uncertainty regarding how hos...

    Authors: Kyle D. Miller, Amie M. Ashcraft, Courtney S. Pilkerton and Carl D. Shrader
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:80
    Content type: Case report Published on:

  7. Asthma, allergic rhinitis and eczema have been identified as the most prevalent childhood allergic diseases. However, the prevalence of these allergic diseases can vary in different regions within a country an...

    Authors: Jagath C. Ranasinghe, Ruchira R. Karunarathne, Thilini S. Munasinghe, Gihani U. Vidanapathirana and Sanath T. Kudagammna
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:79
    Content type: Research Published on:

  8. Oral corticosteroids reduce the antibody titer of the BNT162b2 mRNA vaccine against SARS-CoV-2. To date, the effect of inhaled corticosteroids on antibody titers is unknown.

    Authors: Takeo Nakajima, Tatsuya Nagano, Yoshiharu Miyata, Shoko Murakami, Satoshi Mitsuyuki, Yohei Funakoshi, Kimikazu Yakushijin, Hitoshi Horimoto, Yoshihiro Nishimura and Kazuyuki Kobayashi
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:78
    Content type: Research Published on:

  9. Patterns of aeroallergen sensitization vary by countries. Testing with the minimum number of allergens is important to identify sensitized patients for a cost-effective approach. We aimed to assess the minimal...

    Authors: Prapasri Kulalert, Orapan Poachanukoon, Sira Nanthapisal, Paskorn Sritipsukho, Karnsinee Thanborisutkul, Pasistha Termworasin, Rungrawee Kornsawai and Patcharaporn Punyashthira
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:77
    Content type: Research Published on:

  11. Allergies constitute an important public health problem, and epidemiological data is crucial to developing strategies for its prevention and therapy. Few population-based studies are available for data on alle...

    Authors: Felix King, Robert Kaczmarczyk, Alexander Zink, Tilo Biedermann and Knut Brockow
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:75
    Content type: Research Published on:

  12. Although the prevalence of allergic diseases, including food allergies, has increased over recent decades, relevant information on this topic is still lacking, particularly in younger children living in small ...

    Authors: José A. da S. Correia, Adriana Azoubel Antunes, Luiz Taborda-Barata, José Laerte Boechat and Emanuel Sávio Cavalcanti Sarinho
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:74
    Content type: Research Published on:

  13. Constipation has been hypothesized to be associated with the increased risk of wheezing or asthma. However, the relation remains a subject of debate. We conducted this meta-analysis to assess whether constipat...

    Authors: Lu Liu, Xiangli Zhang, Zhengdong Jiang, Guizuo Wang, Hua Wu, Ruilin Chen, Yongqing Zhang, Manxiang Li and Shumei Yang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:73
    Content type: Research Published on:

  14. We compared patient and caregiver knowledge and confidence for managing asthma, and participant experiences when comprehensive asthma education was delivered in person versus in the virtual setting.

    Authors: Dhenuka Radhakrishnan, Andrea Higginson, Madhura Thipse, Marc Tessier and Arun Radhakrishnan
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:72
    Content type: Research Published on:

  15. Our recent observational study showed that regular consumption of cow’s milk (CM) formula during early infancy (3–6 months old) was associated with a reduced risk of CM allergy (CMA) at 12 months old. However,...

    Authors: Kota Ikari, Junichiro Tezuka, Masafumi Sanefuji, Jiro Nakayama, Daisuke Nishima, Yuri Sonoda, Masanobu Ogawa, Masayuki Shimono, Reiko Suga, Satoshi Honjo, Koichi Kusuhara and Shouichi Ohga
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:71
    Content type: Research Published on:

  16. Real-world data on transitioning to Immune Globulin Subcutaneous (Human) 20% solution (Ig20Gly) are limited. This study aimed to assess infusion parameters and experience of patients with primary (PID) or seco...

    Authors: Paul K. Keith, Juthaporn Cowan, Amin Kanani, Harold Kim, Gina Lacuesta, Jason K. Lee, Jie Chen, Michelle Park and André Gladiator
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:70
    Content type: Research Published on:

  17. Drug-induced hypersensitivity syndrome (DIHS) is a rare, potentially life-threatening systemic drug reaction. Antithyroid drugs (ATDs) causing DIHS have seldom been reported before.

    Authors: Fang Wu, Ting Jin, Chengxin Shang, Xihua Lin, Xiaoqin Gong and Zhou Wang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:69
    Content type: Case report Published on:

  18. Ear, nose, and throat involvement are common in eosinophilic granulomatosis with polyangiitis (EGPA). Among otologic manifestation, middle ear effusion (MEE) is less recognized but a problematic condition as i...

    Authors: Noeul Kang, Joongbo Shin, Yang-Sun Cho, Jin-Young Lee, Byung-Jae Lee and Dong-Chull Choi
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:68
    Content type: Research Published on:

  19. Olfactory dysfunction is recognized as a symptom of COVID-19. Reports revealed the nasal calcium increase has adverse effects on olfactory function. Tetra sodium pyrophosphate, a chelating agent, can bind calc...

    Authors: Mohamed H. Abdelazim, Ahmed H. Abdelazim and Waleed Moneir
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:67
    Content type: Research Published on:

  20. Several miRNAs are now known to have clear connections to the pathogenesis of asthma. The present study focused on the potential role of miR-3934 during asthma development.

    Authors: Liyan Dou, Wenyu Wang, Junwei Wang, Xiaofei Zhang, Xiaoman Hu, Weili Zheng, Kaiyu Han and Guangyou Wang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:66
    Content type: Research Published on:

  21. Authors: Ignacio J. Ansotegui, Jonathan A. Bernstein, Giorgio W. Canonica, Sandra N. Gonzalez-Diaz, Bryan L. Martin, Mario Morais-Almeida, Margarita Murrieta-Aguttes and Mario Sanchez Borges
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:65
    Content type: Correction Published on:

    The original article was published in Allergy, Asthma & Clinical Immunology 2022 18:41

  22. Hereditary angioedema (HAE) is a rare, autosomal disorder that manifests with unpredictable episodes of severe swelling of the skin and mucous membranes. These attacks can be highly disfiguring and range in se...

    Authors: Florence Ida Hsu, William Lumry, Marc Riedl and Raffi Tachdjian
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:64
    Content type: Review Published on:

    The Correction to this article has been published in Allergy, Asthma & Clinical Immunology 2022 18:81

  23. Allergen immunotherapy (AIT) is the only treatment that has modified the natural history of allergic diseases. However, since its overall effect on the immune system has not been elucidated, AIT is either abso...

    Authors: Kazuki Fujioka, Akiko Kasahara, Takashi Kida, Wataru Fujii, Takahiro Seno, Makoto Wada, Masataka Kohno and Yutaka Kawahito
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:63
    Content type: Research Published on:

  24. Owing to a collaborative approach to patient care, and a paucity of allergists in Canada, there is a need to develop a food allergy educational program for allied health care professionals in Canada. Such prog...

    Authors: Jennifer L. P. Protudjer, Carina Venter, Marion Groetch, Tara Lynn Mary Frykas, Jasmin Lidington and Harold Kim
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:62
    Content type: Letter to the editor Published on:

  25. Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a serious and potentially life-threatening form of wheat allergy. Further episodes can only be prevented by avoiding wheat ingestion or avoiding exercise...

    Authors: Zhirong Du, Xiang Gao, Junda Li, Lun Li, Juan Liu and Jia Yin
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:61
    Content type: Research Published on:

  26. Hereditary angioedema (HAE) is a rare, life-threatening disease. The knowledge about the molecular pathogenesis of HAE has derived mainly from investigating blood samples. However, limited data are available o...

    Authors: Henriette Farkas, Csilla Máj, István Kenessey, Anna Sebestyén, Ildikó Krencz, Judit Pápay and László Cervenak
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:60
    Content type: Research Published on:

  27. Allergies, including food allergies, are a considerable clinical and public-health problem. The introduced preventive measures and differential diagnostics, including oral food challenges, are the gold standar...

    Authors: Edyta Krzych-Fałta, Oksana Wojas, Piotr Samel-Kowalik, Adam J. Sybilski and Bolesław Samoliński
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:59
    Content type: Case report Published on:

  28. Kimura disease (KD) is a rare chronic idiopathic condition of unknown etiology that is prevalent in Asian males. It often causes subcutaneous lumps and enlarged lymph nodes, especially in head and neck region....

    Authors: Ruiyun Fan, Guopeng Xu, Ying Chen, Jinghuan Lv and Zhongwei Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:58
    Content type: Case report Published on:

  29. The mechanism of action behind anaphylactic reactions to the mRNA COVID-19 vaccines remains unknown, but the excipient polyethylene glycol, PEG-2000, has been implicated. Initial recommendations were made for ...

    Authors: Daniel H. Li, Erika Lee and Christine Song
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:57
    Content type: Case report Published on:

  30. Air pollution may induce or reinforce nasal inflammation regardless of allergy status. There is limited direct clinical evidence informing the treatment of airborne pollution-related rhinitis.

    Authors: Yuan Zhang, Chunguang Shan, Weiwei Liu, Yaozhong Han, Guanggang Shi, Yongjian Ma, Kerstin Wagner, Xiaoyan Tian, Lili Zhang, Allan Joseph Larona, Steven Sacavage, Kathleen Franklin, Chengshuo Wang and Luo Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:56
    Content type: Research Published on:

  31. The microtubule-dependent molecular motor protein Kinesin Family Member 2A (KIF2A) is down-regulated in asthmatic human airway epithelium. However, little is known about the roles of KIF2A as well as the possi...

    Authors: Zhengxia Wang, Jingjing Wu, Jingxian Jiang, Qiyun Ma, Meijuan Song, Tingting Xu, Yanan Liu, Zhongqi Chen, Yanmin Bao, Mao Huang, Mingshun Zhang and Ningfei Ji
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:55
    Content type: Research Published on:

  32. Food protein-induced enterocolitis syndrome is a non-IgE-mediated reaction to food that is poorly understood, and underdiagnosed. Trigger foods can belong to any food group, but are most commonly milk, soy, ri...

    Authors: Samantha Wong, Lucy Duan, Alana Galper, Adelle Atkinson, Julia Upton and Thomas Eiwegger
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:54
    Content type: Letter to the editor Published on:

  33. Public health measures to mitigate the COVID-19 pandemic have altered health care for chronic conditions. The impact of the COVID-19 pandemic on paediatric asthma, the most common chronic respiratory cause of ...

    Authors: Nusrat Homaira, Nan Hu, Louisa Owens, Mei Chan, Melinda Gray, Philip N Britton, Hiran Selvadurai, Raghu Lingam and Adam Jaffe
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:53
    Content type: Letter to the editor Published on:

  34. Platelet-activating factor (PAF) has been suggested to be a potent inflammatory mediator in Allergic rhinitis (AR) pathogenesis. Vitamin E, an essential nutrient that comprises tocopherol and tocotrienol, is k...

    Authors: Cheryl Wei Ling Teo, Stephanie Jia Ying Png, Yee Wei Ung and Wei Ney Yap
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:52
    Content type: Research Published on:

  35. A food ladder is a form of home-based dietary advancement therapy that gradually increases exposure to an allergenic food through the gradual introduction of egg or milk containing food with increasing quantit...

    Authors: Gilbert T. Chua, Edmond S. Chan, Joanne Yeung, Scott B. Cameron, Lianne Soller, Brock A. Williams, Alanna Chomyn, Timothy K. Vander Leek, Elissa M. Abrams, Raymond Mak and Tiffany Wong
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:51
    Content type: Letter to the editor Published on:

  36. 22q11.2 Deletion Syndrome (22q11.2DS) can result in array of congenital abnormalities including immune dysfunction. International guidelines recommend immune evaluation of 22q11.2DS patients prior to live vacc...

    Authors: Sophie McGregor, Matthew Boroditsky, Geraldine Blanchard-Rohner, Christine Loock and Kyla Jade Hildebrand
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:50
    Content type: Research Published on:

  37. The Rosaceae family includes fruits, such as peach, apple, Japanese apricot, cherry (Prunoideae subfamily), and strawberry (Rosoideae subfamily). The allergens responsible for Rosaceae fruit allergies have bee...

    Authors: Chisato Inuo, Fumiko Okazaki, Rie Shiraki, Yutaka Tanaka, Keiko Momma, Yasuto Kondo and Hiroshi Narita
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:49
    Content type: Case report Published on:

  38. Patients with asthma frequently over rely on short-acting beta-agonists (SABA) to treat acute symptoms. This can adversely impact quality of life and increase the risk of exacerbations. SABA overuse is also as...

    Authors: Anne K. Ellis, Vanessa Foran, Alan Kaplan and Patrick D. Mitchell
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:48
    Content type: Letter to the editor Published on:

  39. The entire school community contributes to the safety of students with food allergy. We sought to determine the food allergy perceptions and education needs of parents, students and school staff, with the goal...

    Authors: Nancy Ross, Sandra Dalke, Shauna Filuk, Bev Kulbaba, Diane Marks, Jo-Anne St-Vincent and Elinor Simons
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:47
    Content type: Research Published on:

  41. Human inborn errors of immunity (IEI) are a group of inherited genetic disorders of the immune system. IEI Patients suffer from severe repeated infections, autoimmunity, lymphadenopathy and/or increased suscep...

    Authors: Safa Meshaal, Rabab EI Hawary, Alia Eldash, Aya Erfan, Dalia Abd Elaziz, Radwa Alkady, Sohilla Lotfy, Nermeen Galal, Jeannette Boutros and Aisha Elmarsafy
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:45
    Content type: Research Published on:

  42. Specific immunotherapy for patients with honey bee hypersensitivity is commonly applied. Re-challenge with venom is performed to prove protection in individual cases.

    Authors: Sara Micaletto, Kurt Ruetzler, Martin Bruesch and Peter Schmid-Grendelmeier
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:44
    Content type: Case report Published on:

  43. One of the main barriers to vaccination against SARS-CoV-2 is the fear of developing hypersensitivity reactions to any of its components. Although these reactions are very rare, it is necessary to establish an...

    Authors: Vicente Jover Cerdá, Ramón Rodríguez Pacheco, Joan Doménech Witek, Sonia Alonso Hernández, Rafael Durán García, Marina Real Panisello and Francisco Manuel Marco de la Calle
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:43
    Content type: Research Published on:

  44. Globally, a small proportion (5–12%) of asthma patients are estimated to have severe disease. However, severe asthma accounts for disproportionately high healthcare resource utilization. The Global Initiative ...

    Authors: William J. Calhoun and Geoffrey L. Chupp
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:42
    Content type: Review Published on:

  45. The present narrative review provides a comprehensive update of the current knowledge on urticaria, both in adult and pediatric populations, and on the safety and efficacy of fexofenadine hydrochloride (HCl) a...

    Authors: Ignacio J. Ansotegui, Jonathan A. Bernstein, Giorgio W. Canonica, Sandra N. Gonzalez-Diaz, Bryan L. Martin, Mario Morais-Almeida, Margarita Murrieta-Aguttes and Mario Sanchez Borges
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:41
    Content type: Review Published on:

    The Correction to this article has been published in Allergy, Asthma & Clinical Immunology 2022 18:65

  46. More and more studies had suggested that dyslipidemia was closely related to allergic diseases. High density lipoprotein (HDL) often plays anti-inflammatory and anti-oxidative roles by suppressing immune cell ...

    Authors: Shengli Gao, Qingxiang Zeng, Yinhui Zeng, Yiquan Tang and Wenlong Liu
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:40
    Content type: Research Published on:

  47. Bronchial thermoplasty (BT) is an effective treatment in severe asthma. How to select patients who more likely benefit from BT is an unmet clinical need. Moreover, mechanisms of BT efficacy are still largely u...

    Authors: Nicola Facciolongo, Martina Bonacini, Carla Galeone, Patrizia Ruggiero, Francesco Menzella, Giulia Ghidoni, Roberto Piro, Chiara Scelfo, Chiara Catellani, Alessandro Zerbini and Stefania Croci
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:39
    Content type: Research Published on:

  48. Patients with primary immunodeficiency (PID) are at increased risk for infections such as SARS-CoV-2 (COVID-19), due to the nature of their diseases and being immunocompromised. At this time, four vaccines aga...

    Authors: Babak Aberumand, Whitney Ayoub Goulstone and Stephen Betschel
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:38
    Content type: Research Published on:

  49. Shared learnings from the early use of novel therapies can aid in their optimization. The recent introduction of peanut oral immunotherapy (peanut OIT; Palforzia [Peanut (Arachis hypogaea) Allergen Powder-dnfp]) ...

    Authors: Jay Portnoy, Christina E. Ciaccio, Janet Beausoleil, George Du Toit, Stanley Fineman, Stephen A. Tilles, June Zhang, Claire Lawrence, Mohamed Yassine and S Shahzad Mustafa
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:37
    Content type: Short report Published on:

  50. Infants at high risk for developing a food allergy have either an atopic condition (such as eczema) themselves or an immediate family member with such a condition. Breastfeeding should be promoted and supporte...

    Authors: Elissa M. Abrams, Wade Watson, Timothy K. Vander Leek, Adelle Atkinson, Marie-Noel Primeau, Marie-Josee Francoeur, Mary McHenry, Elana Lavine, Julia Orkin, Carl  Cummings, Becky Blair and Edmond S. Chan
    Citation: Allergy, Asthma & Clinical Immunology 2022 18:36
    Content type: Position Article and Guidelines Published on:

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