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  1. Case Report

    Systemic mastocytosis with KIT V560G mutation presenting as recurrent episodes of vascular collapse: response to disodium cromoglycate and disease outcome

    Mastocytosis are rare diseases characterized by an accumulation of clonal mast cells (MCs) in one or multiple organs or tissues. Patients with systemic mastocytosis (SM), whose MCs frequently arbor the activat...

    Iolanda Conde-Fernandes, Rita Sampaio, Filipa Moreno, José Palla-Garcia, Maria dos Anjos Teixeira, Inês Freitas, Esmeralda Neves, Maria Jara-Acevedo, Luis Escribano and Margarida Lima

    Allergy, Asthma & Clinical Immunology 2017 13:21

    Published on: 24 April 2017

  2. Research

    Regulation of Th2 responses by different cell types expressing the interleukin-31 receptor

    Interleukin-31 (IL-31) is a recently identified cytokine produced by Th2 cells that is involved in the development of atopic dermatitis-induced skin inflammation and pruritus. Its receptor, IL-31RA, is express...

    Saburo Saito, Ayana Aoki, Iwao Arai, Shinya Takaishi, Haruyasu Ito, Nobutake Akiyama and Hiroshi Kiyonari

    Allergy, Asthma & Clinical Immunology 2017 13:23

    Published on: 17 April 2017

  3. Research

    Preconception allergen sensitization can induce B10 cells in offspring: a potential main role for maternal IgG

    The mechanisms through which allergies can be inhibited after preconception immunization with allergens are not fully understood. We aimed to evaluate whether maternal immunization can induce a regulatory B (B...

    Marília Garcia de Oliveira, Luana de Mendonça Oliveira, Aline Aparecida de Lima Lira, Fábio da Ressureição Sgnotto, Alberto José da Silva Duarte, Maria Notomi Sato and Jefferson Russo Victor

    Allergy, Asthma & Clinical Immunology 2017 13:22

    Published on: 17 April 2017

  4. Meeting abstracts

    Canadian Society of Allergy and Clinical Immunology annual scientific meeting 2016

    Mohammad A. Alsayegh, Hanan Alshamali, Mousa Khadada, Amanda Ciccolini, Anne K. Ellis, Diana Quint, William Powley, Laurie Lee, Yahya Fiteih, Shairaz Baksh, Harissios Vliagoftis, Sebastien K. Gerega, Brad Millson, Katia Charland, Stephane Barakat, Xichun Sun…

    Allergy, Asthma & Clinical Immunology 2017 13(Suppl 1):16

    Published on: 7 April 2017

    This article is part of a Supplement: Volume 13 Supplement 1

  5. Research

    Sputum cell counts to manage prednisone-dependent asthma: effects on FEV1 and eosinophilic exacerbations

    Prednisone dependence in asthma is usually described based on clinical and spirometric characteristics. It is generally believed that these patients have frequent exacerbations and lose lung function rapidly b...

    Afia Aziz-Ur-Rehman, Angira Dasgupta, Melanie Kjarsgaard, Frederick E. Hargreave and Parameswaran Nair

    Allergy, Asthma & Clinical Immunology 2017 13:17

    Published on: 4 April 2017

  6. Research

    Consumer preferences for food allergen labeling

    Food allergen labeling is an important tool to reduce risk of exposure and prevent anaphylaxis for individuals with food allergies. Health Canada released a Canadian food allergen labeling regulation (2008) an...

    Carlo A. Marra, Stephanie Harvard, Maja Grubisic, Jessica Galo, Ann Clarke, Susan Elliott and Larry D. Lynd

    Allergy, Asthma & Clinical Immunology 2017 13:19

    Published on: 4 April 2017

  7. Research

    Efficacy and safety of setipiprant in seasonal allergic rhinitis: results from Phase 2 and Phase 3 randomized, double-blind, placebo- and active-referenced studies

    Antagonism of chemoattractant receptor-homologous molecule on T-helper type-2 cells (CRTH2), a G-protein coupled receptor for prostaglandin D2, could be beneficial for treating allergic disorders. We present f...

    Paul Ratner, Charles P. Andrews, Frank C. Hampel, Bruce Martin, Dale E. Mohar, Denis Bourrelly, Parisa Danaietash, Sara Mangialaio, Jasper Dingemanse, Abdel Hmissi and Jay van Bavel

    Allergy, Asthma & Clinical Immunology 2017 13:18

    Published on: 4 April 2017

  8. Research

    Elevated expression of TIGIT on CD3+CD4+ T cells correlates with disease activity in systemic lupus erythematosus

    It is well-known that lymphocytes play an important role in systemic lupus erythematosus (SLE). T cell immunoreceptor with Ig and immunoreceptor tyrosine-based inhibitory domains (TIGIT) is one of immunosuppre...

    Qing Luo, Jianqing Ye, Lulu Zeng, Xue Li, Le Fang, Beihua Ju, Zikun Huang and Junming Li

    Allergy, Asthma & Clinical Immunology 2017 13:15

    Published on: 28 February 2017

  9. Review

    Gene therapy for primary immune deficiencies: a Canadian perspective

    The use of gene therapy (GT) for the treatment of primary immune deficiencies (PID) including severe combined immune deficiency (SCID) has progressed significantly in the recent years. In particular, long-term...

    Xiaobai Xu, Chetankumar S. Tailor and Eyal Grunebaum

    Allergy, Asthma & Clinical Immunology 2017 13:14

    Published on: 27 February 2017

  10. Case Report

    An avoidable cause of thymoglobulin anaphylaxis

    Thymoglobulin® (anti-thymocyte globulin [rabbit]) is a purified pasteurised, gamma immune globulin obtained by immunisation of rabbits with human thymocytes. Anaphylactic allergic reactions to a first injectio...

    S. Brabant, A. Facon, F. Provôt, M. Labalette, B. Wallaert and C. Chenivesse

    Allergy, Asthma & Clinical Immunology 2017 13:13

    Published on: 23 February 2017

  11. Letter to the editor

    Allergic rhinitis: the eligible candidate to mite immunotherapy in the real world

    As standard drug treatment of allergic rhinitis (AR) is not completely satisfactory, allergen immunotherapy (AIT) represents the only current treatment with the potential to modify the natural history. House d...

    Giorgio Ciprandi, Valentina Natoli, Paola Puccinelli and Cristoforo Incorvaia

    Allergy, Asthma & Clinical Immunology 2017 13:11

    Published on: 21 February 2017

  12. Letter to the editor

    Primum non nocere—first do no harm. And then feed peanut

    The Addendum Guidelines for the Prevention of Peanut Allergy in the United StatesReport of the NIAID-Sponsored Expert Panel were developed to build on previous food allergy guidelines after several key studies d...

    Kyla Jade Hildebrand, Elissa Michele Abrams, Timothy K. Vander Leek, Julia Elizabeth Mainwaring Upton, Douglas P. Mack, Linda Kirste, Christine McCusker and Sandeep Kapur

    Allergy, Asthma & Clinical Immunology 2017 13:7

    Published on: 8 February 2017

  13. Research

    Prevalence of allergen sensitization in 1000 adults in Saskatchewan

    The prevalence of sensitization varies geographically based on multiple environmental factors including humidity. The aim of this study was to determine the prevalence of atopy in symptomatic adults. More impo...

    Stacey D. Lok, Beth E. Davis and Donald W. Cockcroft

    Allergy, Asthma & Clinical Immunology 2017 13:9

    Published on: 8 February 2017

  14. Research

    Day-time variation of serum periostin in asthmatic adults treated with ICS/LABA and adults without asthma

    We aimed to determine the effect of sampling time during the day on serum periostin levels in adult participants with and without asthma.

    Rachel Caswell-Smith, Terrianne Cripps, Thom Charles, Alexander Hosking, Meghana Handigol, Cecile Holweg, John Matthews, Mark Holliday, Corentin Maillot, James Fingleton, Mark Weatherall, Richard Beasley and Irene Braithwaite

    Allergy, Asthma & Clinical Immunology 2017 13:8

    Published on: 8 February 2017

  15. Research

    Prediction of clinical peanut allergy status among children in Hamilton, Ontario using chart review data collected during 2012–2015

    Peanut sensitization does not necessarily indicate clinical peanut allergy, and uncertainty as to whether or not there is true peanut allergy can lead to increased anxiety and decreased quality of life for pat...

    Elizabeth Simms, Gary Foster, Katherine Arias, Mark Larché, Tosha Freitag, Tina Walker, Susanna Goncharova, Andrea Marrin, Andreas Freitag, Manel Jordana and Susan Waserman

    Allergy, Asthma & Clinical Immunology 2017 13:10

    Published on: 8 February 2017

  16. Short report

    Hereditary angioedema: health-related quality of life in Canadian patients as measured by the SF-36

    Hereditary angioedema (HAE) is a rare but serious condition characterized by recurrent spontaneous attacks of angioedema affecting superficial tissues of upper respiratory and gastrointestinal tracts. The pote...

    Nina Lakhani Jindal, Elaine Harniman, Nieves Prior, Elia Perez-Fernandez, Teresa Caballero and Stephen Betschel

    Allergy, Asthma & Clinical Immunology 2017 13:4

    Published on: 19 January 2017

  17. Case report

    Airway autoimmune responses in severe eosinophilic asthma following low-dose Mepolizumab therapy

    Anti-interleukin (IL)-5 monoclonal antibodies as an eosinophil-depleting strategy is well established, with Mepolizumab being the first biologic approved as an adjunct treatment for severe eosinophilic asthma.

    Manali Mukherjee, Hui Fang Lim, Sruthi Thomas, Douglas Miller, Melanie Kjarsgaard, Bruce Tan, Roma Sehmi, Nader Khalidi and Parameswaran Nair

    Allergy, Asthma & Clinical Immunology 2017 13:2

    Published on: 6 January 2017

  18. Position article and guidelines

    Addendum guidelines for the prevention of peanut allergy in the United States: report of the National Institute of Allergy and Infectious Diseases-sponsored expert panel

    Food allergy is an important public health problem because it affects children and adults, can be severe and even life-threatening, and may be increasing in prevalence. Beginning in 2008, the National Institut...

    Alkis Togias, Susan F. Cooper, Maria L. Acebal, Amal Assa’ad, James R. Baker, Lisa A. Beck, Julie Block, Carol Byrd-Bredbenner, Edmond S. Chan, Lawrence F. Eichenfield, David M. Fleischer, George J. Fuchs, Glenn T. Furuta, Matthew J. Greenhawt, Ruchi S. Gupta, Michele Habich…

    Allergy, Asthma & Clinical Immunology 2017 13:1

    Published on: 6 January 2017

  19. Review

    Asthma and the microbiome: defining the critical window in early life

    Asthma is a chronic inflammatory immune disorder of the airways affecting one in ten children in westernized countries. The geographical disparity combined with a generational rise in prevalence, emphasizes th...

    Leah T. Stiemsma and Stuart E. Turvey

    Allergy, Asthma & Clinical Immunology 2017 13:3

    Published on: 6 January 2017

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