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  1. Multiple sclerosis (MS) and neuromyelitis optica syndrome disease (NMOSD) are inflammatory diseases of the central nervous system. The pathogenesis and treatments for these two conditions are very different. N...

    Authors: Leila Khani, Mir Hadi Jazayeri, Reza Nedaeinia, Mahmood Bozorgmehr, Seyed Masood Nabavi and Gordon A. Ferns

    Citation: Allergy, Asthma & Clinical Immunology 2022 18:5

    Content type: Research

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  2. Hereditary angioedema (HAE) is characterized by potentially severe and life-threatening attacks of localized swelling. Prophylactic therapies are available, including attenuated androgens. Efficacy of attenuat...

    Authors: Marcus Maurer, Markus Magerl, Emel Aygören-Pürsün, Konrad Bork, Henriette Farkas, Hilary Longhurst, Sorena Kiani‑Alikhan, Laurence Bouillet, Isabelle Boccon-Gibod, Mauro Cancian, Andrea Zanichelli and David Launay

    Citation: Allergy, Asthma & Clinical Immunology 2022 18:4

    Content type: Case report

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  3. Airway obstruction (AO) in asthma is driven by airway smooth muscle (ASM) contraction. AO can be induced extrinsically by direct stimulation of ASM with contractile agonists as histamine, or by indirect provoc...

    Authors: Mayra D. Álvarez-Santos, Marisol Álvarez-González, Elizabeth Eslava-De-Jesus, Angel González-López, Ivonne Pacheco-Alba, Yazmín Pérez-Del-Valle, Rodrigo Rojas-Madrid and Blanca Bazán-Perkins

    Citation: Allergy, Asthma & Clinical Immunology 2022 18:3

    Content type: Research

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  4. Nodular regenerating hyperplasia (NRH) is the most common liver involvement in common variable immunodeficiency (CVID). Most patients are asymptomatic with gradually increasing alkaline phosphatase (ALP) and mild...

    Authors: Mongkhon Sompornrattanaphan, Ranista Tongdee, Chamard Wongsa, Anupop Jitmuang and Torpong Thongngarm

    Citation: Allergy, Asthma & Clinical Immunology 2022 18:2

    Content type: Case report

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  5. The Icatibant Outcome Survey (IOS) is an international registry monitoring the use of icatibant, a bradykinin B2 receptor antagonist indicated for the acute treatment of hereditary angioedema (HAE) attacks. Our g...

    Authors: Mar Guilarte, Anna Sala-Cunill, María Luisa Baeza, Rosario Cabañas, María Dolores Hernández, Ethel Ibañez, Carlos Hernando de Larramendi, Ramon Lleonart, Teófilo Lobera, Luis Marqués, Blanca Sáenz de San Pedro, Jaco Botha, Irmgard Andresen and Teresa Caballero

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:137

    Content type: Research

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  6. True allergy to metronidazole, a common anti-infective in clinical practice, is rarely reported in the literature. In the case of Trichomonas, there are few alternatives to the nitrimidazole class of drugs, and t...

    Authors: Julia A. Cahill, Preena Simritpreet Sahota and Manstein Kan

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:136

    Content type: Case report

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  7. The relationship between allergies and sinusitis, though extensively studied, remains poorly defined. While several studies proposed a cause-and-effect relationship between allergy and chronic sinusitis, sever...

    Authors: Song Li, Chu-Jin Zhao, Hong-Li Hua, Yu-Qin Deng and Ze-Zhang Tao

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:135

    Content type: Research

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  8. There exists a geographic barrier to access CIA care for patients who live in rural communities; telemedicine may bridge this gap in care. Herein we characterized the use of telemedicine in CIA at a population...

    Authors: Erika Yue Lee, Christine Song, Peter Vadas, Matthew Morgan and Stephen Betschel

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:131

    Content type: Letter to the Editor

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  9. Epinephrine is the first line treatment for anaphylaxis, an acute potentially life-threatening allergic reaction. It is typically administered intramuscularly in the anterolateral thigh at a dose of 0.01 mg/kg...

    Authors: Lucy Dong Xuan Li, Elissa M. Abrams, Elana Lavine, Kyla Hildebrand and Douglas Paul Mack

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:130

    Content type: Position article and guidelines

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  10. The Global Initiative for Asthma has only recently added tiotropium bromide as adjunct controller therapy in severe asthma (Step 4 or 5) in adults (2015) and children (2019). Although not yet approved for pedi...

    Authors: Zainab Ridha, Marc-Antoine Bédard, Anna Smyrnova, Olivier Drouin, Aniela Pruteanu, Sandrine Essouri and Francine M. Ducharme

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:129

    Content type: Research

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  11. Refractory status asthmaticus is the cause of rare cases of in-hospital death due to acute bronchial asthma. The most severe cases unresponsive to first, second and next line treatment may be fatal despite agg...

    Authors: Jan Benes, Roman Skulec, Dalibor Jilek, Ondrej Fibigr and Vladimir Cerny

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:128

    Content type: Case Report

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  12. Post hoc analyses of randomized placebo-controlled trials have demonstrated efficacy and tolerability of the ragweed sublingual immunotherapy (SLIT)-tablet in Canadian adults with ragweed pollen-induced allerg...

    Authors: Anne K. Ellis, Remi Gagnon, David I. Bernstein and Hendrik Nolte

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:127

    Content type: Research

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  13. Dedicator of cytokinesis 2 (DOCK2) deficiency is an inborn error of immunity characterized by cellular and humoral immunological abnormalities leading to early-onset infections.

    Authors: Niusha Sharifinejad, Homa Sadri, Arash Kalantari, Samaneh Delavari, Amirhosein Noohi, Yasaman Aminpour, Araz Sabzevari and Gholamreza Azizi

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:126

    Content type: Case Report

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  14. Sublingual immunotherapy tablets (SLIT-T) are an effective treatment for allergic rhinitis (AR), but some patients experience local allergic reactions (LAR) in the first few weeks of treatment that can lead to...

    Authors: Anne K. Ellis, Lori Connors, Marie-Josee Francoeur and Douglas P. Mack

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:125

    Content type: Case Report

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  15. Granulomatosis with polyangiitis (GPA) is a syndrome of refractory vasculitis involving the upper respiratory tract, lungs, kidneys, and systemic small and medium-sized arteries that affects all age groups. No...

    Authors: Memi Kato, Keisuke Jimbo, Masumi Nagata, Yoshiko Endo, Kosuke Kashiwagi, Kimiko Maruyama, Natsuki Ito, Kaori Tokushima, Nobuyasu Arai, Reiko Kyodo, Masamichi Sato, Eri Miyata, Kenji Hosoi, Eisuke Inage, Tamaki Ikuse, Hideo Fukunaga…

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:124

    Content type: Case Report

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  16. Asthma is one of the most common chronic diseases in childhood and is generally characterized by exercise induced bronchoconstriction (EIB). Assessing EIB is time consuming and expensive as it requires a fully...

    Authors: M. R. van der Kamp, J. M. M. Driessen, M. P. van der Schee, B. J. Thio and F. H. C. de Jongh

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:121

    Content type: Research

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  17. The hygiene hypothesis posits that microbial exposure reduces risk of asthma and other respiratory-related diseases. Helicobacter pylori and hepatitis A virus (HAV) are common fecal–oral infections. Our study aim...

    Authors: Christian S. Alvarez, M. Larissa Avilés-Santa, Neal D. Freedman, Krista M. Perreira, Olga Garcia-Bedoya, Robert C. Kaplan, Martha L. Daviglus, Barry I. Graubard, Gregory A. Talavera, Bharat Thyagarajan and M. Constanza Camargo

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:120

    Content type: Short Report

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  18. Increased levels of serum Immunoglobulin-E (IgE) and different genetic variants of cytokines are common biochemical manifestation in Allergy. The current study was aimed to study the association of IgE and dif...

    Authors: Taha Ashraf Qurashi, Aaliya Shah, Gulzar Ahmad Bhat, Mosin Saleem Khan, Roohi Rasool and Syed Mudassar

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:119

    Content type: Research

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  19. Allergic bronchopulmonary aspergillosis (ABPA) and chronic eosinophilic pneumonia (CEP) both display peripheral eosinophilia as well as pulmonary infiltration, together described as pulmonary eosinophilia, and...

    Authors: Mari Miki, Yuko Ohara, Kazuyuki Tsujino, Takahiro Kawasaki, Tomoki Kuge, Yuji Yamamoto, Takanori Matsuki, Keisuke Miki and Hiroshi Kida

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:118

    Content type: Research

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  20. Symptom control is a major concern in chronic urticaria. Histobulin™ is a histamine/immunoglobulin complex that has been approved for allergic rhinitis, bronchial asthma and chronic urticaria in some countries...

    Authors: Hyuk Soon Kim and Geunwoong Noh

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:116

    Content type: Case Report

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  21. Severe combined immunodeficiency (SCID) is a rare genetic condition characterized by significant T cell lymphopenia and impaired T cell function. Many jurisdictions use the quantitation of T cell receptor exci...

    Authors: Adil Adatia, Ling Ling, Pranesh Chakraborty, Lauren Brick and Rae Brager

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:115

    Content type: Letter to the Editor

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  22. Periplaneta americana and Blattella germanica cockroaches are widespread, and risk of sensitization increases in urban environments where these roaches thrive as household pests. There are no prior reports of Bla...

    Authors: Hannah Wangberg, Jun Mendoza, Robert Gomez, Christopher Coop, Andrew White and Katharine Woessner

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:114

    Content type: Case Report

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  23. Allergic rhinitis (AR) is the most common undiagnosed chronic condition in children. Moderate/severe AR symptoms significantly impair quality of life, and cause sleep disruption, absenteeism and decreased prod...

    Authors: Eli O. Meltzer, Nelson Augusto Rosario, Hugo Van Bever and Luiz Lucio

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:113

    Content type: Review

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  24. Treatment with immune checkpoint inhibitors has revolutionized cancer treatment over the past several years. Despite their clinical benefits, a wide range of immune-mediated toxicities can be observed includin...

    Authors: Romy G. Younan, Roy A. Raad, Bassem Y. Sawan and Rabih Said

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:112

    Content type: Case Report

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  25. Several primary studies evaluated the association between rhinitis and the incidence of depression and yielded inconsistent results. We conducted a meta-analysis of studies evaluating the association between r...

    Authors: Jing Wang, Dongqiong Xiao, Huayou Chen and Juan Hu

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:111

    Content type: Review

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  26. Intimacy-related allergic reactions, including anaphylaxis, are under-reported due to social stigma, lack of awareness, and misdiagnosis. The differential diagnosis for intimacy-related anaphylaxis is extensiv...

    Authors: Lundy R. McKibbin, Sidney Kin-Hung Siu, Hannah T. Roberts, Michael Shkrum and Samira Jeimy

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:110

    Content type: Case Report

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  27. Currently there is no systematic review and meta-analysis of the global incidence rates of anaphylactic and nonanaphylactic reactions to SARS-CoV-2 vaccines in the general adult population.

    Authors: Saad Alhumaid, Abbas Al Mutair, Zainab Al Alawi, Ali A. Rabaan, Raghavendra Tirupathi, Mohammed A. Alomari, Aqeel S. Alshakhes, Abeer M. Alshawi, Gasmelseed Y. Ahmed, Hassan M. Almusabeh, Tariq T. Alghareeb, Abdulaziz A. Alghuwainem, Zainab A. Alsulaiman, Mohammed A. Alabdulmuhsin, Emad A. AlBuwaidi, Amjad K. Bu Dukhi…

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:109

    Content type: Research

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  28. The Global Initiative for Asthma recommends the use of as-needed low-dose inhaled corticosteroid (ICS)-formoterol as a preferred controller therapy for patients with mild asthma. These recommendations were bas...

    Authors: Mohsen Sadatsafavi, J. Mark FitzGerald, Paul M. O’Byrne, Mena Soliman, Niroshan Sriskandarajah, Colin Vicente and Sarowar Muhammad Golam

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:108

    Content type: Research

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  29. Severe combined immunodeficiency (SCID) is a group of relatively rare primary immunodeficiency disorders (PIDs), characterized by disturbed development of T cells and B cells, caused by several genetic mutatio...

    Authors: Fatemeh Sadat Mahdavi, Mohammad Keramatipour, Sarina Ansari, Samin Sharafian, Arezou Karamzade and Marzieh Tavakol

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:107

    Content type: Case Report

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  30. The symptoms of patients with respiratory disease are influenced by local environmental factors. The incidence of allergic rhinitis in grassland areas was significantly higher than that in non-grassland areas....

    Authors: Xu Xu, Long Qin, Lei Ren, Chengshuo Wang, Yuan Zhang and Luo Zhang

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:106

    Content type: Research

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  31. Since the outbreak of the novel coronavirus disease (COVID-19), the therapeutic and management options to reduce the burden of the COVID-19 disease are under investigation. IVIG therapy is used as an effective...

    Authors: Zahra Kolahchi, Hanye Sohrabi, Sara Ekrami Nasab, Hesan Jelodari Mamaghani, Maryam Keyfari Alamdari and Nima Rezaei

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:105

    Content type: Review

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  32. The determination of systemic inflammatory markers is one of the important directions to study the pathogenesis of asthma and improve the diagnosis of asthma. Current studies have found that the 14-3-3 protein...

    Authors: Decai Wang, Lizong Rao, Yalan Cui, Guoting Tang, Haiming Huang, Ting Yuan and Biwen Mo

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:104

    Content type: Research

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  33. C1 inhibitor (C1-INH) and complement 4 (C4) have historically been referred to as positive acute phase reactants, however this has never been evaluated in hereditary angioedema (HAE) patients. Low function of ...

    Authors: Peter Stepaniuk, Ana-Maria Bosonea, Persia Pourshahnazari, Adrienne Roos and Amin Kanani

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:103

    Content type: Case Report

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  34. Knowledge is limited about the relationship between clinical reactivity to foods through breastfeeding and long-term food allergy outcomes. We explored parent-perceived symptoms of food allergy via breastfeedi...

    Authors: Abigail Lang, Shrey Patel, Karen Rychlik, Deanna Caruso, Xiaobin Wang, Jacqueline A. Pongracic and Rajesh Kumar

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:102

    Content type: Research

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  35. Peanut and soybean allergies are listed as contraindication in the package leaflet of isotretinoin, a widely used treatment of acne vulgaris. Cross-reactivity between PR10-proteins in peanut, tree nuts, and so...

    Authors: Anna Bamidis and Silke C. Hofmann

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:101

    Content type: Case Report

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  36. Hereditary angioedema (HAE) is a rare genetic disorder characterized by unpredictable localized episodes of edema, which is frequently managed with long-term prophylactic medications. Until recently, long-term...

    Authors: Richard G. Gower and Mary Wilber

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:100

    Content type: Case Report

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  37. Jellyfish stings are known to induce allergic skin reactions; however, case reports of anaphylaxis after jellyfish ingestion have been increasing, especially in Asian countries. Some cases of anaphylaxis after...

    Authors: Mitsuru Tsuge, Masanori Ikeda, Osamu Mitani, Masato Yasui and Hirokazu Tsukahara

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:99

    Content type: Case Report

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  38. We present a case of CVID complicated by granulomatous interstitial lung disease (GLILD). This patient clinical course was further complicated by COVID-19 infection. This is only the 2nd known case report of C...

    Authors: Debendra Pattanaik, Shaunah Ritter and Joseph Fahhoum

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:98

    Content type: Case Report

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  39. Hen’s eggs are one of the most common causes of food allergy. Although hen’s eggs are known to cause more gastrointestinal symptoms than other foods, it is not known whether there is a difference in organ-spec...

    Authors: Kei Uneoka, Satoshi Horino, Ayafumi Ozaki, Haruka Aki, Masako Toda and Katsushi Miura

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:97

    Content type: Letter to the Editor

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  40. Atopic dermatitis is the most common chronic inflammatory skin disease and presents a major public health burden worldwide. Recent observational studies revealed the potential association between atopic dermat...

    Authors: Zhiyu Lu, Ni Zeng, Yuxin Cheng, Yihe Chen, Yueyue Li, Qian Lu, Qingyue Xia and Dan Luo

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:96

    Content type: Review

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  41. The prevalence of comorbidities and their relation to asthma control and treatment is a topic of increasing interest, however comprehensive studies are scarce. We aimed to determine the prevalence of the most ...

    Authors: Gábor Tomisa, Alpár Horváth, Balázs Sánta, András Keglevich and Lilla Tamási

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:95

    Content type: Research

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  42. It is well known that atopic dermatitis (AD) is associated with other allergic diseases. Recentely, links to diseases other than allergic disease have also been actively studied. Among them, the results of stu...

    Authors: Hye Jung Jung, Dong Heon Lee, Mi Youn Park and Jiyoung Ahn

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:94

    Content type: Research

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  43. There is currently a dramatic increase in the number of COVID-19 cases worldwide, and further drastic restrictions in our daily life will be necessary to contain this pandemic. The implications of restrictive ...

    Authors: Nicole Maison, Heidrun Herbrüggen, Bianca Schaub, Christina Schauberger, Svenja Foth, Ruth Grychtol, Mustafa Abdo, Henrik Watz, Wilfried Nikolaizik, Klaus F. Rabe, Matthias V. Kopp, Gesine Hansen, Erika von Mutius, Thomas Bahmer and Jimmy Omony

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:93

    Content type: Letter to the Editor

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