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  1. In this letter to the editor, we present questionnaire-based data assessing the patient journey of adults with moderate–severe Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) in the USA and five European cou...

    Authors: Jeremiah Hwee, Lauren Lee, Mark Small, Steven G. Smith, Victoria S. Benson and Shiyuan Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:17
  2. Correlations between mitochondrial DNA (mtDNA) and allergic rhinitis (AR) have not been reported before. This study aimed to better understand the mitochondrial genome profile with AR and to investigate the as...

    Authors: Huajie Yuan, Lingling Wang, Song Wang, Linge Li, Qingping Liu, Yan Wang, Yuping Yang and Hua Zhang
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:16
  3. While a connection has been established between serum interleukin-6 (IL-6) levels and the IL-6 gene (− 174G/C) polymorphism in allergic diseases such as asthma, its specific association with severe asthma remains...

    Authors: Mona Al-Ahmad, Asmaa Ali, Ahmed Maher and Mohammad Z. Haider
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:15
  4. Chronic Rhinosinusitis (CRS) is a paranasal sinus inflammatory disease and is divided into two subgroups defined as CRS with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). CRSwNP displays a T hel...

    Authors: Javad Nazari, Faezeh Shahba, Negin Jafariaghdam, Saleh Mohebbi, Saba Arshi, Mohammad Hassan Bemanian, Morteza Fallahpour, Sima Shokri, Fatemeh Atashrazm, Saeed Amini, Maryam Roomiani, Mahnaz Jamee, Pegah Babaheidarian, Majid Khoshmirsafa and Mohammad Nabavi
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:14
  5. According to the Th1/Th2 paradigm, the expansion of Th1-type clones in individuals with type 1 diabetes results in reduced Th2-type clones, preventing the development of atopic diseases and vice versa. However...

    Authors: Júlia Marchatto Kamei, Raissa Dias Maués, Gabriel de Oliveira Silva, Alessandra Helena Machado, Erika Megumi Hoshino, Fabiana Menezes Bacchiega, Laís Mota Furtado Sena and Carlos Antonio Negrato
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:12
  6. Mepolizumab, the first widely available anti-interleukin 5 biologic, targets eosinophilic inflammation and has been shown in clinical trials to reduce exacerbations, oral corticosteroid dependence, and healthc...

    Authors: Kenneth R. Chapman, Kathryn Cogger, Erin Arthurs, Callahan LaForty, Shane Golden, Bradley Millson, Koyo Usuba and Christopher Licskai
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:11
  7. Obstructive sleep apnea (OSA) occurs more commonly in asthma patients than in the general population because these conditions share some comorbidities. In Japan, the prevalence of OSA in the general population...

    Authors: Mina Yasuda, Kazunori Tobino, Norihiro Harada, Ryunosuke Ooi, Takuto Sueyasu, Saori Nishizawa, Miyuki Munechika, Kohei Yoshimine, Yuki Ko, Yuki Yoshimatsu, Kosuke Tsuruno, Hiromi Ide and Kazuhisa Takahashi
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:10
  8. Food protein-induced enterocolitis syndrome (FPIES) is a non-immunoglobulin E (IgE) -mediated food allergy predominantly observed in infants and characterized by the delayed onset of vomiting following ingesti...

    Authors: Hunter Hall, Sara Anvari, Fallon Schultz, Olubukola Ojuola and Nicholas L. Rider
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:9
  9. Proteinase-activated receptor 2 (PAR-2) is a G-protein coupled receptor associated with many inflammatory diseases, including asthma. We have shown an association between PAR-2 expression in peripheral blood m...

    Authors: Nami Shrestha Palikhe, Qahir Haji, Emily Mack, Tristan Sinnatamby, Andrew J. Sandford, Lisa Cameron and Harissios Vliagoftis
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:8
  10. Inborn errors of immunity (IEIs) are a group of conditions whereby parts of the immune system are missing or dysfunctional. Once thought to primarily be a pediatric disorder, it is now estimated that more than...

    Authors: Joanne J. F. Wang, Arün Dhir, Kyla J. Hildebrand, Stuart E. Turvey, Robert Schellenberg, Luke Y. C. Chen, Persia Pourshahnazari and Catherine M. Biggs
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:6
  11. Poor sleep health is associated with increased asthma morbidity and mortality. Accelerometers have been validated to assess sleep parameters though studies using this method in patients with asthma are sparse ...

    Authors: Varun Sharma, Helen Clare Ricketts, Femke Steffensen, Anna Goodfellow, Duncan S Buchan and Douglas C Cowan
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:5
  12. H. pylori is a gram-negative bacterium that is usually acquired in childhood and can persistently colonize the gastric mucosa of humans, affecting approximately half of the world’s population. In recent years,...

    Authors: Mengmeng Liu, Yong Wang and Bing Du
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:4
  13. Interleukin (IL)-36 family is closely associated with inflammation and consists of IL-36α, IL-36β, IL-36γ, and IL-36Ra. The role of IL-36 in the context of asthma and asthmatic phenotypes is not well character...

    Authors: Jinyan Li, Zhengda Wang, Hongna Dong, Yuqiu Hao, Peng Gao and Wei Li
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:3
  14. Allergic asthma and rhinitis (AR) are closely linked, with a significant proportion of AR patients developing asthma. Identification of the early signs of comorbidity of AR and asthma can enable prompt treatme...

    Authors: Myung Woul Han, Song Hee Kim, Inbo Oh, Yang ho Kim and Jiho Lee
    Citation: Allergy, Asthma & Clinical Immunology 2024 20:1
  15. Increasing evidence suggests that hormone therapy (HT) and obesity exert an influence on allergic rhinitis (AR). It is important to investigate the association and interactions between HT, BMI, and AR in perim...

    Authors: Jingyi Liu, Tingting Ma, Xiaoxue Wang, Wenpei Bai and Xueyan Wang
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:107
  16. Real-world data on subcutaneous C1INH (C1INH[SC]) usage and patient-level impacts on hereditary angioedema (HAE)-related outcomes and quality of life (QoL) are both lacking and challenging to generate using co...

    Authors: William Lumry, Timothy Craig, John Anderson, Marc Riedl, Henry Li, Raffi Tachdjian, Michael Manning, Paolo Bajcic, Frank Rodino, Sam Wang, Thomas R. Sexton and Jonathan A. Bernstein
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:105
  17. Several biologics are now approved in the US as add-on treatments for chronic rhinosinusitus with nasal polyps (CRSwNP). This cross-sectional, retrospective, real-world study aimed to characterize treatment pa...

    Authors: Jared Silver, Elizabeth Packnett, Julie Park and Arijita Deb
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:104
  18. Non-esophageal eosinophilic gastrointestinal disorder (non-EoE-EGID) is a rare disease in which eosinophils infiltrate parts of the gastrointestinal tract other than the esophagus; however, the number of patie...

    Authors: Mitsuru Tsuge, Kenji Shigehara, Kazuhiro Uda, Seiji Kawano, Masaya Iwamuro, Yukie Saito, Masato Yashiro, Masanori Ikeda and Hirokazu Tsukahara
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:103
  19. The diagnosis of Alpha-gal Syndrome (AGS) is based on the presence of symptoms after being exposed to potential sources of alpha-gal together with values ​​of specific IgE (sIgE) to alpha-gal ≥ 0.1 kUA/L or ≥ ...

    Authors: Adrián Germán-Sánchez, Ana Alonso-Llamazares, Fernando García-González, Bakai Matala-Ahmed, Ceny Solani Melgar-Reyes and Ignacio Antepara-Ercoreca
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:102
  20. Childhood atopic dermatitis can have a negative effect on caregivers’ quality of life and stress levels due to the burdensome nature of its treatment. Given that the condition often emerges in infancy, atopic ...

    Authors: Ayel Luis R. Batac, Kaitlyn A. Merrill, Michael A. Golding, Manvir Bhamra, Zoe Harbottle, Isac Kopsch, Erik Wilking, Marina Jonsson, Sandra Ekström, Elissa M. Abrams, Michelle A. Halbrich, Elinor Simons, Leslie E. Roos, Jill A. Keddy-Grant, Thomas V. Gerstner, Jo-Anne St-Vincent…
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:100
  21. Food allergies (FA) can detrimentally impact physical, emotional, and psychological quality of life (QoL) among pediatric patients. Given the changes from childhood into adolescence, the impact of FA on QoL li...

    Authors: Diem-Tran I. Nguyen, Kathleen Pitts, Kristen A. Staggers and Carla M. Davis
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:99
  22. Human placental extract (HPE) has been documented to facilitate the healing of certain disorders including allergy. However, the effects of HPE on the functionality of mast cells, a critical cell type in aller...

    Authors: Tongqian Wu, Jingjing He, Shirong Yan, Jing Li, Ke Chen, Dingshan Zhang, Mingliang Cheng, Zou Xiang and Yu Fang
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:98
  23. Although numerous studies have suggested a negative correlation between Helicobacter pylori (H. pylori) infection and allergies, there has been limited research on the relationship between H. pylori infections an...

    Authors: Shuxian Wang, Xiaokang Wang, Jiaqi Liu, Yaqian Li, Minghui Sun, Guoqiang Zhu and Xiaofang Zhu
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:97
  24. Hypersensitivity pneumonitis (HP) is usually caused by the inhalation of avian and fungal proteins. The present study assesses a cohort of Urban Pest Surveillance and Control Service (UPSCS) workers with high ...

    Authors: Silvia Sánchez-Díez, Xavier Muñoz, Tomás Montalvo, Iñigo Ojanguren, Christian Romero-Mesones, Juan Carlos Senar, Victor Peracho-Tobeña and María-Jesús Cruz
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:96
  25. Most asthma diagnoses and patient care take place in primary care settings. Electronic medical records (EMRs) offer an opportunity to utilize technology to improve asthma diagnosis and care. The purpose of thi...

    Authors: Max Moloney, Alison Morra, Rachael Morkem, John Queenan, Samir Gupta, Teresa To, Geneviève Digby, David Barber and M. Diane Lougheed
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:95
  26. Food ladders are tools designed to facilitate home-based dietary advancement in children with food allergies through stepwise exposures to increasingly allergenic forms of milk and egg. Several studies have no...

    Authors: Alanna Chomyn, Edmond S. Chan, Joanne Yeung, Scott Cameron, Gilbert T. Chua, Timothy K. Vander Leek, Brock A Williams, Lianne Soller, Elissa M. Abrams, Raymond Mak and Tiffany Wong
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:94
  27. Osimertinib has emerged as an important tool in the treatment of non-small cell lung cancers (NSCLC) with certain activating mutations of epidermal growth factor receptor (EGFR). However, Osimertinib may cause...

    Authors: Michael Lopez, Garo Hagopian, Linda Doan, Benjamin J. Lee, Nathan W. Rojek, Janellen Smith, Sai-Hong Ignatius Ou, Yesim Yilmaz Demirdag and Misako Nagasaka
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:93
  28. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) syndrome is a rare but severe and sometimes fatal adverse drug reaction that is known to occur with a number of antiepileptic drugs. It often follo...

    Authors: Khanh Duy Doan, Adeyinka Akinsanya, Matthew Kuhar and Hector Mesa
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:92
  29. There is an urgent need to understand the interplay between SARS-CoV-2 and HIV to inform risk-mitigation approaches for HIV-infected individuals.

    Authors: Shima Shahbaz, Wendy Sligl, Mohammed Osman and Shokrollah Elahi
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:91
  30. Dupilumab, omalizumab, and mepolizumab are the three biologics currently approved for use in CRSwNP in Canada. Despite evidence of efficacy, their cost-effectiveness, which is a key factor influencing prescrib...

    Authors: Michael Yong, Keshinisuthan Kirubalingam, Martin Y. Desrosiers, Shaun J. Kilty and Andrew Thamboo
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:90
  31. Atopic dermatitis (AD) is a chronic inflammatory skin disease that affects children and adults. Poor treatment adherence in AD requires interventions to promote self-management; patient education in chronic di...

    Authors: Bethany Wilken, M. Zaman and Y. Asai
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:89
  32. Penicillin allergy is the most commonly reported drug allergy in the US. Despite evidence demonstrating that up to 90% of labels are incorrect, scalable interventions are not well established. As part of a lar...

    Authors: Esra Alagoz, Megan Saucke, Prakash Balasubramanian, Paul Lata, Tyler Liebenstein and Sujani Kakumanu
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:88
  33. Current management of food protein-induced enterocolitis syndrome (FPIES) involves strict avoidance of the offending food for 12–18 months, followed by oral food challenge (OFC) under physician supervision. OF...

    Authors: Linlei Ye, Tiffany Wong, Elana Lavine, Victoria E. Cook and Stephanie C. Erdle
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:87
  34. Activated phosphoinositide3-kinase (PI3K) δ syndrome 1 (APDS1) is a novel inborn errors of immunity (IEIs) caused by heterozygous gain of function mutations in PI3Kδ catalytic p110δ (PIK3CD). APDS1 has a spect...

    Authors: Lu Jiang, Xiaohan Hu, Qiang Lin, Ruyue Chen, Yunyan Shen, Yun Zhu, Qinying Xu and Xiaozhong Li
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:86
  35. Canada has high immunoglobulin (IG) product utilization, raising concerns about appropriate utilization, cost and risk of shortages. Currently, there is no national set of standardized IG guidelines, and consi...

    Authors: Megan Harmon, Kiarash Riazi, Jeannie Callum, Donald M. Arnold, Rebecca Barty, Davinder Sidhu, Nancy M. Heddle, Laurie MacLeod and Na Li
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:85
  36. Idiopathic Anaphylaxis (IA) is the most common anaphylactic syndrome in adults. Mental health problems associated with IA are not well recognised. We aimed to assess if patients diagnosed with IA were more lik...

    Authors: Logan S Gardner, Zihao Tan, David Brown, David Gillis, James G. Scott and Roger Prentice
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:84
  37. To investigate the role of combined impulse oscillometry (IOS) and fractional exhaled nitric oxide (FeNO) in the diagnosis of cough variant asthma (CVA) in preschool children.

    Authors: Ying Hu, Shouyan Zheng, Zhiqiang Chen, Dan Yu, Tianxia Lai, Yao Chen and Wei Liao
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:83
  38. Anaphylaxis is an acute, potentially life-threatening allergic reaction that typically occurs after exposure to a trigger, while idiopathic anaphylaxis (IA) occurs in the absence of a trigger. Acute management...

    Authors: Elizabeth Pepper and Luke Pittman
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:82
  39. The prevalence of eosinophilic asthma in Lebanon, one of the most severe phenotypes among severe asthma, is not known. This study aimed at determining the prevalence of the eosinophilic phenotype defined as an...

    Authors: Wajdi Abi Saleh, Zuhair Alameh, Zeina Aoun Bacha, Joudy Bahous, Pierre Bou Khalil, Zahia Chahine, Hassan Chami, Georges Dabar, Hassan Dheiny, Alfred Dib, Dany farhat, Carla Irani, Georges Juvelekian, Nadim Kanj, Bassam Mansour, Moussa Riachi…
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:80
  40. Interleukin (IL)-36 family cytokines have received increasing attention, especially in the fields of inflammation and immunity research. However, whether IL-36 family cytokine levels are correlated with the re...

    Authors: Jia Gu, Gang Qin, Liang Jiang, Wei Xu, Yuanyuan Wang, Jiangxue Liao, Hongzhu Pan and Zhuoping Liang
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:79
  41. Autophagy protein 5 (ATG5) regulates airway epithelial cell autophagy, immune response, and inflammation, which is involved in asthma progression. This study aimed to evaluate ATG5 levels and its clinical role...

    Authors: Changjiang Ke and Sheng Xie
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:77
  42. Respiratory conditions, such as asthma, are infrequently associated with auto-inflammatory diseases. We describe five patients with uncontrolled respiratory symptoms that were seen at St. Joesph’s Healthcare i...

    Authors: Bashayr M. Alotaibi, Raquel Lopez Rodriguez, Carmen Venegas Garrido, Lucia Gonzalez Bravo, Nader Khalidi and Parameswaran Nair
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:76
  43. Immunoglobulin A deficiency (IgAD) is a common disease with an unknown genetic defect, characterized by the decreased or absent IgA with other isotypes normal, normal subclasses, and specific antibodies. Patie...

    Authors: Ahmad Vosughimotlagh, Seyed Erfan Rasouli, Hosein Rafiemanesh, Molood Safarirad, Niusha Sharifinejad, Atossa Madanipour, Maria Marluce Dos Santos Vilela, Edyta Heropolitańska-Pliszka and Gholamreza Azizi
    Citation: Allergy, Asthma & Clinical Immunology 2023 19:75

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