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  1. The Global Initiative for Asthma recommends the use of as-needed low-dose inhaled corticosteroid (ICS)-formoterol as a preferred controller therapy for patients with mild asthma. These recommendations were bas...

    Authors: Mohsen Sadatsafavi, J. Mark FitzGerald, Paul M. O’Byrne, Mena Soliman, Niroshan Sriskandarajah, Colin Vicente and Sarowar Muhammad Golam

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:108

    Content type: Research

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  2. Severe combined immunodeficiency (SCID) is a group of relatively rare primary immunodeficiency disorders (PIDs), characterized by disturbed development of T cells and B cells, caused by several genetic mutatio...

    Authors: Fatemeh Sadat Mahdavi, Mohammad Keramatipour, Sarina Ansari, Samin Sharafian, Arezou Karamzade and Marzieh Tavakol

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:107

    Content type: Case Report

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  3. The symptoms of patients with respiratory disease are influenced by local environmental factors. The incidence of allergic rhinitis in grassland areas was significantly higher than that in non-grassland areas....

    Authors: Xu Xu, Long Qin, Lei Ren, Chengshuo Wang, Yuan Zhang and Luo Zhang

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:106

    Content type: Research

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  4. Since the outbreak of the novel coronavirus disease (COVID-19), the therapeutic and management options to reduce the burden of the COVID-19 disease are under investigation. IVIG therapy is used as an effective...

    Authors: Zahra Kolahchi, Hanye Sohrabi, Sara Ekrami Nasab, Hesan Jelodari Mamaghani, Maryam Keyfari Alamdari and Nima Rezaei

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:105

    Content type: Review

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  5. The determination of systemic inflammatory markers is one of the important directions to study the pathogenesis of asthma and improve the diagnosis of asthma. Current studies have found that the 14-3-3 protein...

    Authors: Decai Wang, Lizong Rao, Yalan Cui, Guoting Tang, Haiming Huang, Ting Yuan and Biwen Mo

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:104

    Content type: Research

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  6. C1 inhibitor (C1-INH) and complement 4 (C4) have historically been referred to as positive acute phase reactants, however this has never been evaluated in hereditary angioedema (HAE) patients. Low function of ...

    Authors: Peter Stepaniuk, Ana-Maria Bosonea, Persia Pourshahnazari, Adrienne Roos and Amin Kanani

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:103

    Content type: Case Report

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  7. Knowledge is limited about the relationship between clinical reactivity to foods through breastfeeding and long-term food allergy outcomes. We explored parent-perceived symptoms of food allergy via breastfeedi...

    Authors: Abigail Lang, Shrey Patel, Karen Rychlik, Deanna Caruso, Xiaobin Wang, Jacqueline A. Pongracic and Rajesh Kumar

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:102

    Content type: Research

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  8. Peanut and soybean allergies are listed as contraindication in the package leaflet of isotretinoin, a widely used treatment of acne vulgaris. Cross-reactivity between PR10-proteins in peanut, tree nuts, and so...

    Authors: Anna Bamidis and Silke C. Hofmann

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:101

    Content type: Case Report

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  9. Hereditary angioedema (HAE) is a rare genetic disorder characterized by unpredictable localized episodes of edema, which is frequently managed with long-term prophylactic medications. Until recently, long-term...

    Authors: Richard G. Gower and Mary Wilber

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:100

    Content type: Case Report

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  10. Jellyfish stings are known to induce allergic skin reactions; however, case reports of anaphylaxis after jellyfish ingestion have been increasing, especially in Asian countries. Some cases of anaphylaxis after...

    Authors: Mitsuru Tsuge, Masanori Ikeda, Osamu Mitani, Masato Yasui and Hirokazu Tsukahara

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:99

    Content type: Case Report

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  11. We present a case of CVID complicated by granulomatous interstitial lung disease (GLILD). This patient clinical course was further complicated by COVID-19 infection. This is only the 2nd known case report of C...

    Authors: Debendra Pattanaik, Shaunah Ritter and Joseph Fahhoum

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:98

    Content type: Case Report

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  12. Hen’s eggs are one of the most common causes of food allergy. Although hen’s eggs are known to cause more gastrointestinal symptoms than other foods, it is not known whether there is a difference in organ-spec...

    Authors: Kei Uneoka, Satoshi Horino, Ayafumi Ozaki, Haruka Aki, Masako Toda and Katsushi Miura

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:97

    Content type: Letter to the Editor

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  13. Atopic dermatitis is the most common chronic inflammatory skin disease and presents a major public health burden worldwide. Recent observational studies revealed the potential association between atopic dermat...

    Authors: Zhiyu Lu, Ni Zeng, Yuxin Cheng, Yihe Chen, Yueyue Li, Qian Lu, Qingyue Xia and Dan Luo

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:96

    Content type: Review

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  14. The prevalence of comorbidities and their relation to asthma control and treatment is a topic of increasing interest, however comprehensive studies are scarce. We aimed to determine the prevalence of the most ...

    Authors: Gábor Tomisa, Alpár Horváth, Balázs Sánta, András Keglevich and Lilla Tamási

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:95

    Content type: Research

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  15. It is well known that atopic dermatitis (AD) is associated with other allergic diseases. Recentely, links to diseases other than allergic disease have also been actively studied. Among them, the results of stu...

    Authors: Hye Jung Jung, Dong Heon Lee, Mi Youn Park and Jiyoung Ahn

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:94

    Content type: Research

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  16. There is currently a dramatic increase in the number of COVID-19 cases worldwide, and further drastic restrictions in our daily life will be necessary to contain this pandemic. The implications of restrictive ...

    Authors: Nicole Maison, Heidrun Herbrüggen, Bianca Schaub, Christina Schauberger, Svenja Foth, Ruth Grychtol, Mustafa Abdo, Henrik Watz, Wilfried Nikolaizik, Klaus F. Rabe, Matthias V. Kopp, Gesine Hansen, Erika von Mutius, Thomas Bahmer and Jimmy Omony

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:93

    Content type: Letter to the Editor

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  17. Allergen extracts used in subcutaneous immunotherapy can be standardized or non-standardized. Standardized extracts are available in specific biological potencies, presumably making their biological activity m...

    Authors: Benny Dua, Jane Park and Harold Kim

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:92

    Content type: Research

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  18. An allergy to kiwi is rare in Poland. Most (65–72%) of the patients who are allergic to kiwi report symptoms of an oral allergy syndrome (OAS); however, systemic manifestations (18–28%) have also been reported.

    Authors: Natalia Ukleja-Sokołowska, Robert Zacniewski, Kinga Lis, Magdalena Żbikowska-Gotz, Andrzej Kuźmiński and Zbigniew Bartuzi

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:91

    Content type: Case Report

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  19. Tocilizumab has been shown to be effective for treatment of juvenile idiopathic arthritis (JIA). To our knowledge, this is the first reported case of interstitial lung disease occurring shortly after tocilizum...

    Authors: Koichi Sugihara, Risa Wakiya, Hiromi Shimada, Mikiya Kato, Tomohiro Kameda, Shusaku Nakashima, Mai Mahmoud Fahmy Mansour, Yusuke Ushio, Norimitsu Kadowaki and Hiroaki Dobashi

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:90

    Content type: Case Report

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  20. Exercise-induced anaphylaxis (EIA) is a rare and potentially life-threatening disorder that can develop independently without food ingestion. Cold drinks can also trigger symptoms in some patients with cold-in...

    Authors: Chikako Motomura, Koji Ide, Terufumi Shimoda and Hiroshi Odajima

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:89

    Content type: Case Report

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  21. Toxic epidermal necrolysis (TEN)/Stevens–Johnson syndrome (SJS) is the spectrum of severe, acute, mucocutaneous, T-cell mediated delayed type IV hypersensitivity reaction and universally related to different d...

    Authors: Biniyam A. Ayele, Kemal Ali and Eliyas Mulatu

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:88

    Content type: Case Report

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  22. A formulation of black cumin (Nigella sativa L.), licorice (Glycyrrhiza glabra L.), anise (Pimpinella anisum L.) and tea (Camellia sinensis (L.) Kuntze) (denoted BLAB tea) is traditionally used to relief allergy ...

    Authors: Chengsong Liao, Yangyang Han, Zhijing Chen and Huricha Baigude

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:87

    Content type: Research

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  23. Increased intestinal permeability, either due to the exposure to antigens in asthmatic patients or due to a barrier defect, plays a critical role in susceptibility to environmental allergens. House dust mite a...

    Authors: Shereen A. Baioumy, Aya Elgendy, Shereen M. Ibrahim, Sara I. Taha and Shaimaa H. Fouad

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:86

    Content type: Research

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  24. Leveraging the data management resources of the Canadian Primary Care Sentinel Surveillance Network (CPCSSN) is a viable approach for describing the prevalence of allergic disease documented in primary care se...

    Authors: Alexander G. Singer, Leanne Kosowan, Nerissa Nankissoor, Ryan Phung, Jennifer L. P. Protudjer and Elissa M. Abrams

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:85

    Content type: Short Report

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  25. Physical effort is capable of triggering airway obstruction in asthmatics, the so-called exercise-induced bronchoconstriction in asthma (EIBa). This study was performed in subjects with mild persistent asthma,...

    Authors: Maroon Salameh, Laura Pini, Federico Quadri, Fabio Spreafico, Damiano Bottone and Claudio Tantucci

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:84

    Content type: Research

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  26. Food ladders are clinical tools already widely used in Europe for food reintroduction in milk- and egg-allergic children. Previously developed milk and egg ladders have limited applicability to Canadian childr...

    Authors: Alanna Chomyn, Edmond S. Chan, Joanne Yeung, Timothy K. Vander Leek, Brock A. Williams, Lianne Soller, Elissa M. Abrams, Raymond Mak and Tiffany Wong

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:83

    Content type: Letter to the Editor

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  27. The expression profiles of the intestinal mucosa have not been comprehensively investigated in asthma. We aimed to explore this in the Correlated Expression and Disease Association Research (CEDAR) patient coh...

    Authors: Jan K. Nowak, Marzena Dworacka, Nazgul Gubaj, Arystan Dossimov, Zhumabek Dossimov and Jarosław Walkowiak

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:82

    Content type: Research

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  28. Drug reaction with eosinophilia and systemic symptoms (DRESS) is a potentially life-threatening hypersensitivity reaction to medication. While a relatively rare phenomenon, early identification and discontinua...

    Authors: Arman Zereshkian and Susan Waserman

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:81

    Content type: Case Report

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  29. Allergic reaction to liposomal amphotericin B is rare. We report a case of cardiac arrest in a 64-year-old woman following liposomal amphotericin B infusion, requiring resuscitation. We also present the result...

    Authors: George P. Drewett, Ana Copaescu, Joseph DeLuca, Natasha E. Holmes and Jason A. Trubiano

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:80

    Content type: Case Report

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  30. Insulin hypersensitivity is rare, but challenging for individuals with diabetes. The prevalence of insulin allergy has decreased since the introduction of human recombinant insulin preparations. Hypersensitivi...

    Authors: Babak Aberumand and Samira Jeimy

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:79

    Content type: Case Report

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  31. Hereditary angioedema (HAE) is a rare autosomal dominant disease resulting in recurring episodes of swelling, leading to considerable patient morbidity and mortality. Lanadelumab is a plasma kallikrein inhibit...

    Authors: Aled Iaboni, Amin Kanani, Gina Lacuesta, Christine Song, Manstein Kan and Stephen D. Betschel

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:78

    Content type: Letter to the Editor

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  32. Body mass index (BMI) is associated with asthma but associations of BMI temporal patterns with asthma incidence are unclear. Previous studies suggest that DNA methylation (DNAm) is associated with asthma statu...

    Authors: Rutu Rathod, Hongmei Zhang, Wilfried Karmaus, Susan Ewart, Latha Kadalayil, Caroline Relton, Susan Ring, S. Hasan Arshad and John W. Holloway

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:77

    Content type: Research

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  33. Shrimp allergy is a growing problem among the European population. TSLP, IL-25 and IL-33 are involved in the pathophysiology of allergic diseases, including asthma and atopic dermatitis, as they activate the T...

    Authors: Natalia Ukleja-Sokołowska, Magdalena Żbikowska-Gotz, Kinga Lis, Rafał Adamczak and Zbigniew Bartuzi

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:76

    Content type: Research

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  36. Currently, several biologics are used for the treatment of cutaneous pathologies such as atopic dermatitis (AD), psoriasis or skin cancers. The main administration routes are subcutaneous and intravenous injec...

    Authors: Audrey Baylet, Raoul Vyumvuhore, Marine Laclaverie, Laëtitia Marchand, Carine Mainzer, Sylvie Bordes, Brigitte Closs-Gonthier and Laurent Delpy

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:73

    Content type: Short Report

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  37. We conducted a nationwide Canadian telephone survey on food allergy prevalence between February 2016 and January 2017, targeting vulnerable populations (New, Indigenous, and lower-income Canadians).

    Authors: Ann E. Clarke, Susan J. Elliott, Yvan St. Pierre, Lianne Soller, Sebastien La Vieille and Moshe Ben-Shoshan

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:72

    Content type: Letter to the Editor

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  38. Most Canadian food allergy data has focused on Health Canada’s priority food allergens. This study describes which non-priority (emerging) food allergens were most commonly reported by Canadian parents and cat...

    Authors: Lianne Soller, Sebastien La Vieille, Scott B. Cameron, Raymond Mak, Victoria E. Cook, Jennifer Gerdts and Edmond S. Chan

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:71

    Content type: Letter to the Editor

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  39. Glucocorticoids rarely cause anaphylaxis. Common methods for the determination of allergens include in vivo skin prick test (SPT) and intradermal skin test (IDST) and the in vitro basophil activation test (BAT...

    Authors: Hitomi Amano, Yoshiro Kitagawa, Tomohito Hayakawa, Taichiro Muto, Akihisa Okumura and Hideyuki Iwayama

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:70

    Content type: Case Report

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  40. IL13, IL4, IL4RA, FCER1B and ADRB2 are susceptible genes of asthma and atopy. Our previous study has found gene–gene interactions on asthma between these genes in Chinese Han children. Whether the interactions be...

    Authors: Li Hua, Quanhua Liu, Jing Li, Xianbo Zuo, Qian Chen, Jingyang Li, Yuwei Wang, Haipei Liu, Zhaobo Shen, Yi Li, Zenan Ma, Shengdong Dong, Ruoxu Ji, Dingzhu Fang, Yi Chen, Wenwei Zhong…

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:69

    Content type: Research

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  41. We recently showed that multicomponent traditional Chinese medicine (TCM) therapy had steroid-sparing effects in moderate-to-severe eczema. We sought to evaluate TCM effects in severe eczema in a 7-year-old ma...

    Authors: Serife Uzun, Zixi Wang, Tory A. McKnight, Paul Ehrlich, Erin Thanik, Anna Nowak-Wegrzyn, Nan Yang and Xiu-Min Li

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:68

    Content type: Letter to the Editor

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  42. A significant portion of COVID-19 sufferers have asthma. The impacts of asthma on COVID-19 progression are still unclear but a modifying effect is plausible as respiratory viruses are acknowledged to be an imp...

    Authors: Jian Luo, Yi-Ling Chen, Wentao Chen, David A. Duncan, Alexander Mentzer, Julian C. Knight, Graham Ogg, Paul Klenerman, Ian D. Pavord and Luzheng Xue

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:67

    Content type: Research

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  43. A cost-minimization analysis (CMA) was performed to evaluate the economic implications of introducing the SQ Tree sublingual immunotherapy (SLIT)-tablets marketed as ITULATEK® (Health Canada regulatory approva...

    Authors: Anne K. Ellis, Rémi Gagnon, Eva Hammerby, Julia Shen and Sheena Gosain

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:66

    Content type: Research

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  44. Subcutaneous immunotherapy (SCIT) is an effective treatment for allergic rhinoconjunctivitis. However, adverse events, including life-threatening systemic reactions, may occur. The purpose of this project is t...

    Authors: Adam Aue, Joella Ho, Rongbo Zhu, Harold Kim and Samira Jeimy

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:65

    Content type: Research

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  46. On Wright-stained sputum cytospins, eosinophil differential of ≥ 1.2% is considered abnormal, and ≥ 2.3% identifies an eosinophilic endotype. We hypothesized that failure to consider free eosinophil granules (...

    Authors: Melanie Kjarsgaard, Adil Adatia, Anurag Bhalla, Nicola LaVigne, Katherine Radford, Chynna Huang, Manali Mukherjee and Parameswaran Nair

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:63

    Content type: Research

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  47. Inconsistencies remain regarding the effectiveness and safety of leukotriene receptor antagonists (LTRAs) and selective H1-antihistamines (SAHs) for allergic rhinitis (AR). A meta-analysis of randomized contro...

    Authors: Yan Feng, Ya-Ping Meng, Ying-Ying Dong, Chang-Yu Qiu and Lei Cheng

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:62

    Content type: Review

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  49. While many studies of effective hereditary angioedema (HAE) therapy have demonstrated improved health-related quality of life (HRQoL) using validated instruments, specific reasons behind the improved scores ha...

    Authors: John Anderson, Donald S. Levy, William Lumry, Patricia Koochaki, Sally Lanar and H. Henry Li

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:60

    Content type: Research

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  50. Allergic rhinitis (AR) is one of the most widespread immune conditions worldwide. However, common treatments often present with significant side effects or are cost-prohibitive for much of the population. A pl...

    Authors: Jing Zhou, Yi Lu, Wei Wu and Yunhai Feng

    Citation: Allergy, Asthma & Clinical Immunology 2021 17:59

    Content type: Research

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