The prophylactic use of C1 inhibitor in hereditary angioedema patients undergoing invasive surgical procedures: a retrospective study

Table 4 Medications approved for long-term prophylaxis of HAE attacks

Long-term prophylaxis
Medication class	Example	Dose	Approval
Medication class	Example	Dose	Canada	US	Europe
C1 INH replacement (plasma derived)	Cinryze	1000 U IV every 3-4 days	✓	✓	✓
Attenuated androgens	Danazol	≦ 200 mg PO TID		✓

Of note: androgens are contraindicated in: pregnancy, lactation, and growing children. They are also associated with severe side-effects.

ISSN: 1710-1492