Figure 2
From: T cell unresponsiveness in a pediatric cystic fibrosis patient: a case report
Naïve T cells from Patient A, but not Patient B, showed marked induction of expression of the T cell exhaustion markers LAG-3 and CTLA-4 following stimulation with anti-CD3 and anti-CD28 antibodies. Representative plots of the expression of the T cell exhaustion markers LAG-3 and CTLA-4 on unstimulated naïve T cells from patients A and B, and on T cells following stimulation with anti-CD3 and anti-CD28 antibodies. T cells from patient A, but not patient B, demonstrated a marked induction of the T cell exhaustion markers LAG-3 and CTLA-4. Representative of 2 - 3 independent experiments.