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Life threatening shrimp allergy cross reacting with mite allergy : a case report


Food allergy is apparently increasing and it is estimated that 3–4% of adults have food allergy. Shrimp is one of the most common causatives in seafood allergy. Patients with shrimp allergy may exhibit life threatening anaphylactic reactions. Tropomyosin is a known important allergen in shrimp. The IgE-binding epitope in shrimp tropomyosin, cross-reacts with other allergenic invertebrate tropomyosins in house dust mites (Der p 10, Der f 10) and cockroaches (Per a 7).


this study was undertaken to evaluate the results of immunotherapy to Mites upon allergic reactions to shrimp allergen in a 40 years old female suffering from combined allergy to mites and shrimp. The patient had a 10 years history of severe allergic reactions after eating shrimp; for which she was hospitalized several times to receive intravenous steroids and antihistamines. Despite avoiding consumption of shrimp for several years she continued to have allergic rhinitis symptoms. The last episode of allergic reactions to shrimp occurred while cooking shrimp not eating it.

Materials and methods

Allergy skin prick testing against a panel of 30 common allergens including Mites and shrimp ( Omega, Montreal, Canada) revealed a strong positive wheal and erythema reaction to both shrimp and D. farinae (13mm, 9 mm for wheal and 2.5 cm, 2.3 cm for erythema respectively). Allergen specific serum IgE testing also revealed elevated serum specific IgE to both allergens. The patient started subcutaneous allergen specific immunotherapy (ASIT) against D. farinae using Omega labs allergy shots. Six months after ASIT there was a significant reduction in the size of the wheal and erythema and also significant decrease of serum specific IgE values for both allergens.


Subcutaneous immunotherapy against mites may desensitize patients against shrimp allergy.

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Correspondence to Farag I Farag-Mahmod.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Farag-Mahmod, F.I., Hessam, W.I. Life threatening shrimp allergy cross reacting with mite allergy : a case report. All Asth Clin Immun 10, A9 (2014).

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  • Food Allergy
  • Allergic Rhinitis
  • House Dust Mite
  • Allergen Specific Immunotherapy
  • Allergic Rhinitis Symptom