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Table 1

From: Nonimmunoglobulin E-Mediated Immune Reactions to Foods

Disorder

Symptoms

Diagnostic Testing

Food Involved

Cutaneous

   

   Atopic dermatitis

Chronic relapsing pruritic rash

Skin testing and atopy patch testing

Milk, eggs, soy, peanuts, wheat

   Dermatitis herpetiformis

Marked pruritus; papulovesicular rash over extensor surfaces and buttocks

Skin biopsy (IgA deposition), IgA antigliadin and antitransglutaminase antibodies; ± endoscopy

Gluten

Gastrointestinal

   

   FPIES

Vomiting, diarrhea, progressing to shocklike state

Elimination diet, patch testing

Milk, soy, others

   Eosinophilic esophagitis

Gastroesophageal reflux symptoms, dysphagia, failure to thrive

Elimination diet, skin testing and patch testing

Multiple foods

   Celiac disease

Weight loss, chronic diarrhea, steatorrhea, abdominal distention

IgA antigliadin and antitransglutaminase antibodies, endoscopy

Gluten

Respiratory

   

   Pulmonary hemosiderosis

Recurrent pneumonia, pulmonary infiltrates, iron deficiency anemia, failure to thrive

Clinical history, peripheral eosinophilia, milk precipitins (if caused by milk), ± lung biopsy, elimination diet

Milk, eggs

  1. FPIES = food protein-induced enterocolitis syndrome; IgA = immunoglobulin A.