Navigating the Updated Anaphylaxis Parameters

Table 2 Special Considerations for Anaphylaxis in Children

I	*Age*		*Systolic Blood Pressure (mm Hg)*
When is it hypotension?	Term neonates (0-28 d)		<60
	Infants (1-12 mo)		<70
	Children (>1-10 yr)		<70 + (2× age in yr)
	Beyond 10 yr		<90
II	Medication	Dose Range (μg/kg/min)	Preparation*
Infusion rates for epinephrine and dopamine in children with cardiac arrest or profound hypotension	Dopamine	2-20	6× body weight (in kg) = n of mg diluted to total 100 mL saline; then 1 mL/h delivers 1 μg/kg/min
	Epinephrine	0.1	0.6× body weight (in kg) = n of mg diluted to total 100 mL saline; then 1 mL/h delivers 0.1 μg/kg/min

Adapted with permission from Lieberman P et al. [1]
*Infusion rates shown use the "Rule of 6." An alternative is to prepare a more dilute or more concentrated drug solution based on a standard drug concentration, in which case an individual dose must be calculated for each patient and each infusion rate, as follows: infusion rate (mL/h) = (weight [kg] × dose [μg/kg/min] × 60 min/h)/concentration (μg/mL).

ISSN: 1710-1492