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Table 2 Pro-Studies evaluating Helicobacter pylori (HP) and chronic urticaria (CU), (only studies that included proven eradicated patients)

From: Urticaria and infections

H. pylori proven eradication rate (%)

first treatment regimen (days)

evaluation period in months

Remission or improvement rate (%)

First author

Country

Year

Ref.

   

eradicated HP+ CU

untreated HP+ CU

untreated

HP- CU

  

39/46 (85)

OAC (14)

3

36/39 (92)*

10/20 (50)

nd

Yadav

India

2008

[37]

39/45 (87)

OAC (14)

2 and 4

nd**

nd**

0/33

Magen

Israel

2007

[36]

62/68 (91)

OAC (7)$

nd

41/55 (75)

nd

nd

Vazquez

Spain

2004

[101]

26/26 (100)

OAC (4)$

>12

19/26 (73)

nd

nd

Shiotani

Japan

2001

[76]

24/24 (100)

OAC (7)$

4

19/21 (91)

10/20 (50)

33/53 (62)

Wedi

Germany

1998

[52]

21/21 (100)

BM, ABM or BMT

not specified

20/21 (95)

nd

nd

Kolibasova

Slovakia

1994

[102]

20/20 (100)

OAC (7)

not specified

14/20 (70)

nd

nd

Gaig

Spain

2002

[103]

17/19 (89)

LAC, LAM (7)

2

17/17 (100), CR in 6/17

2/9 (22)

nd

Fukuda

Japan

2004

[34]

17/17 (100)

ABM or OA (7)

not specified

17/17 (100)

nd

nd

Kalas

Hungary

1996

[104]

16/18 (89)

LAC (7)

1-4

16/16 (100)

nd

0/19 (0)

Di Campli

Italy

1998

[105]

15/15 (100)

LAC (7)

>6

9/15 (60)

nd

nd

Sakurane

Japan

2002

[106]

14/17 (82)

OA, OC or OMT (7)

1.5-2.5

14/17 (82)

nd

0/8 (0)

Tebbe

Germany

1996

[107]

12/12 (100)

OAM (7)

not specified

10/12 (83)

nd

nd

Bonamigo

Brazil

1999

[108]

Total

322/348

(93)

§

 

Total

232/276

(84) &

Total

22/49

(45)

Total

33/113 (29)

  
  1. *signif. increase of CU2QoL (p = 0.001)
  2. **signif. Urticaria activity score decrease in eradicated HP+CU but not in untreated HP+CU or untreated HP-CU
  3. $treatment was repeated or a reserve schedule was used until eradication was achieved
  4. §9 of 13 studies (69%) used a triple treatment of proton pump inhibitor (O or L) plus amoxicillin and clarithromycin;
  5. &study by Magen could not be included because remission/improvement rates were not described
  6. Abbreviations: O, omeprazole; A, amoxicillin; C, clarithromycin; B, bismuth; M, metronidazole; T, tetracycline; L, lansoprazole; HP, Helicobacter pylori; CU, chronic urticaria; nd, not done;