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Table 3 Classification of plant allergen families according to their patterns of distribution and IgE cross-reactivity

From: Panallergens and their impact on the allergic patient

Classification Plant allergen family Clinically relevant IgE cross-reactivity between unrelated allergen sources Distribution
    Pollen Plant food Product
    T G W F V N L LA
Panallergens Profilins yes [7] X X X X X X X X
Eurallergens Polcalcins yes [34] X X X      
  nsLTPs yes [78] X   X X X   X X
  PR-10 proteins yes [75] X    X X X X  
  Hevein-like domain proteins yes [79] X    X X X   X
  β-1,3 glucanases yes [80] X    X X    X
Stenallergens Ole e 1-related proteins no X X X      
  Polygalacturonases no X X       
  Pectate lyases no X   X      
  Cyclophilins no X   X      
  Thaumatin-like proteins no X    X X    
  Plant invertases no X    X     
  Isoflavone reductases no X    X     
  PR-1 proteins no   X X      
  Expansins (N-terminal) no   X   X     
  α-amylase/trypsin inhibitors no   X     X   
  Cystatins no    X X     
  Pectin methylesterases no    X X     
  Patatins no      X    X
  Barwin family proteins no      X    X
  Cupins no       X X  
  Fe/Mn Superoxide dismutases no       X   X
  Thioredoxins no       X   X
Monallergens 8 domain proteins - X        
  Heat shock proteins (Hsp70) - X        
  Expansins (C-terminal) -   X       
  Group 5/6 grass allergens -    X      
  Berberine bridge enzymes -   X       
  Protein kinases -    X      
  Group 5 ragweed allergens -   X       
  Papain-like cysteine proteases -     X     
  60S acidic ribosomal proteins -     X     
  Kunitz-type trypsin inhibitors -      X    
  Glycoside hydrolase family 32 proteins -      X    
  Cereal prolamins -       X   
  2S albumins -       X   
  Oleosins -       X   
  Serpin serine protease inhibitors -       X   
  α-amylases -       X   
  Legume lectins -        X  
  Rubber elongation factors -         X
  SGNH-hydrolases -         X
  1. Due to their pattern of distribution and IgE cross-reactivity between unrelated species, plant allergens can be classified as (i) ubiquitously spread cross-reactive "panallergens" (Greek "pan": all), (ii) widespread cross-reactive "eurallergens" (Greek "euros": width), (iii) "stenallergens" (Greek: "stenos": tight), widespread allergen with limited cross-reaction, and (iv) "monallergens" (Greek "monos": single), which are restricted to a single allergen source. Detailed information on allergen families is available from the AllFam database http://www.meduniwien.ac.at/allergens/allfam/[81]. (Abbreviations: T, trees; G, grasses; W, weeds; F, fruits; V, vegetables; N, nuts and seeds; L, legumes; LA, latex)