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Table 4 Univariate analysis of the association of positive skin prick test (SPT) with IL13 and prenatal factors

From: Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study

 

Positive SPT (age 4)

Positive SPT (age 10)

Positive SPT (age 18)

 

n (%)

Exact

n (%)

Exact

n (%)

Exact

Study Variables

N = 981

p-values

N = 1,036

p-values

N = 845

p-values

rs1800925:

      

- TT/CT

56 (21.8)

0.317

94 (28.7)

0.365

105 (43.6)

0.354

- CC

137 (18.9)

 

183 (25.9)

 

242 (40.1)

 

rs2066960:

      

- AA/AC

31 (23.9)

0.195

50 (30.7)

0.247

47 (39.8)

0.840

- CC

162 (19.0)

 

227 (26.0)

 

300 (41.3)

 

rs20541:

      

- AA/GA

54 (20.9)

0.584

89 (27.6)

0.705

98 (42.1)

0.754

- GG

139 (19.2)

 

188 (26.3)

 

249 (40.7)

 

Birth order

      

- First

84 (21.1)

0.549

107 (27.2)

0.950

130 (39.5)

0.121

- Second

67 (19.6)

 

89 (27.6)

 

116 (47.4)

 

- Third or higher

42 (17.5)

 

57 (26.4)

 

73 (39.3)

 

Family Social Status Cluster*

      

- High

20 (23.8)

0.492

19 (22.9)

0.516

25 (36.8)

0.023

- Middle

150 (19.7)

 

221 (27.7)

 

276 (43.1)

 

- Low

23 (17.2)

 

35 (24.3)

 

33 (29.7)

 

Environmental Tobacco Exposure**

      

- ETS-0

100 (21.9)

0.145

141 (28.9)

0.213

183 (43.8)

0.245

- ETS-1

63 (19.4)

 

86 (26.2)

 

97 (38.5)

 

- ETS-2

30 (15.2)

 

49 (22.6)

 

63 (37.5)

 

Gender

      

- Male

109 (22.1)

0.055

158 (30.6)

0.005

188 (46.2)

0.002

- Female

84 (17.2)

 

119 (22.9)

 

156 (35.7)

 

Prematurity (weeks)

      

- < 37

5 (17.2)

1.000

12 (41.4)

0.086

9 (39.1)

1.000

- ≥ 37

183 (19.7)

 

257 (26.2)

 

321 (40.4)

 

Low Birth Weight (g)

      

- < 2500

4 (11.1)

0.283

11 (31.4)

0.559

9 (34.6)

0.685

- ≥ 2500

184 (20.0)

 

256 (26.3)

 

321 (40.7)

 

Maternal History of Atopy

      

- Yes

75 (22.1)

0.178

117 (32.7)

0.002

137 (47.6)

0.005

- No

118 (18.4)

 

160 (23.6)

 

207 (37.4)

 

Maternal IgE

      

- > 100

40 (22.4)

0.223

68 (34.3)

0.002

78 (48.8)

0.002

- ≤ 100

90 (18.0)

 

116 (22.4)

 

146 (34.5)

 

Maternal Atopic Status***

      

- Definite

20 (19.2)

0.355

40 (33.9)

0.010

48 (49.5)

0.008

- Latent

20 (26.7)

 

28 (35.0)

 

30 (47.6)

 

- Probable

24 (18.8)

 

32 (25.0)

 

42 (40.0)

 

- None

66 (17.7)

 

84 (21.5)

 

104 (32.7)

 

Cord Serum IgE

      

- ≥ 0.5

29 (32.2)

0.002

32 (35.6)

0.042

37 (50.0)

0.060

- < 0.5

134 (17.8)

 

201 (25.2)

 

253 (38.4)

 
  1. *"Family social status cluster" is a composite variable derived from a combination of family income, parental occupation (socioeconomic status), and number of children in child's bedroom.
  2. ** ETS-0: mother did not smoke during pregnancy and children not exposed to household ETS; ETS-1: mother did not smoke during pregnancy, but children were exposed to household ETS; ETS-2: mother smoked during pregnancy and children were exposed to household ETS.
  3. ***Maternal atopic status was classified into Definite (elevated IgE, positive history); Latent (elevated IgE, negative history); Probable (normal IgE, positive history); and None (normal IgE, negative history).
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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