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Table 6 Multivariate analysis of the association of inhalant serum IgE at age 10 with IL13 polymorphisms and prenatal factors, overall population, stratified by birth order (n = 588) (PR = Prevalence Ratio)

From: Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study

 

1st Born

2nd Born

3rd and Higher

Study Variables

p

PR (95% CI)

p

PR (95% CI)

p

PR (95% CI)

 

n = 246

n = 212

n = 130

rs20541:

      

-AA/GA vs. GG

0.034

1.48 (1.03, 2.13)

0.120

0.72 (0.48, 1.09)

0.197

1.43 (0.83, 2.45)

Gender (M vs. F)

0.353

1.19 (0.82, 1.72)

0.017

1.58 (1.08, 2.29)

0.496

1.20 (0.71, 2.02)

Smoke Exposure*:

      

- ETS-1 vs. ETS-0

0.075

0.68 (0.44, 1.04)

0.154

0.73 (0.47, 1.13)

0.600

0.84 (0.45, 1.60)

- ETS-2 vs. ETS-0

0.318

0.79 (0.49, 1.26)

0.278

0.74 (0.43, 1.27)

0.672

1.14 (0.60, 2.19)

Family SES Cluster**

      

- Low vs. High

0.070

2.27 (0.94, 5.49)

0.860

0.92 (0.35, 2.43)

0.058

0.23 (0.05, 1.05)

- Middle vs. High

0.435

1.37 (0.62, 3.04)

0.506

1.26 (0.64, 2.46)

0.349

0.69 (0.31, 1.51)

Gestational age

0.240

0.94 (0.85, 1.04)

0.649

1.03 (0.90, 1.18)

0.095

1.26 (0.96, 1.65)

  1. * ETS-0: mother did not smoke during pregnancy and children not exposed to household ETS;
  2. ETS-1: mother did not smoke during pregnancy, but children were exposed to household ETS;
  3. ETS-2: mother smoked during pregnancy and children were exposed to household ETS.
  4. **"Family social status cluster" is a composite variable derived from a combination of family income, parental occupation (socioeconomic status), and number of children in child's bedroom.
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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