Figure 3

Ig induction in offspring after three, five and six doses of A. fumigatus. a) IgE was reduced after the fifth and sixth (p < 0.0001 on ANOVA), but not third (p = NS, ANOVA), doses among offspring mice whose mothers were exposed to either A. fumigatus or diesel exhaust particles or both. *p < 0.01, when compared to saline alone by Tukey HSD. † p < 0.05, when compared to A. fumigatus alone by Tukey HSD b) IgG₁ was greater after the fifth, sixth (p < 0.0001 on ANOVA), but not third (p = NS, ANOVA), doses among mice whose mothers were exposed to either A. fumigatus or diesel exhaust particles or both. *p < 0.01, when compared to saline alone by Tukey HSD. †p < 0.05, when compared to saline alone by Tukey HSD. c) IgG2a was greater after the fifth, sixth (p < 0.0001 on ANOVA) dose among mice whose mothers were exposed to A. fumigatus or diesel exhaust particles plus A. fumigatus. *p < 0.01, when compared to saline alone by Tukey HSD. Levels also were greater among offspring of mothers that were exposed to both diesel exhaust particles and A. fumigatus when compared to offspring of mothers treated either with diesel exhaust or A. fumigatus alone, p < 0.01.†p < 0.01, when compared to diesel exhaust particles alone by Tukey HSD. ‡ p < 0.05 on ANOVA and when compared to saline alone by Tukey HSD. Sample sizes corresponding to the figures vary as follows: Saline 11-14; Diesel 11-15; A. fumigatus: 8-18; Diesel and A. fumigatus 13-25.