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Raw wheat allergy: a case report


There is evidence that individuals with milk and egg allergy may be able to tolerate the allergen in question if it is thoroughly heated. There is no published literature on raw versus cooked wheat allergy. We describe a case of hypersensitivity to raw wheat in an individual who is able to consume cooked wheat products.


The outpatient clinic chart of our patient was reviewed. Our patient gave consent to having her data presented in case report format.


A 28 year-old female with a history of persistent allergic rhinitis and Arterial Tortuosity Syndrome had two episodes of anaphylaxis following a meal. In each instance she had ingested food cooked in batter. Skin prick tests to all foods ingested during the meals, including commercial wheat extract, were negative. Skin prick testing to wheat flour, white flour, the uncooked batter in question, as well as several commercial pancake mixes, were strongly positive. Our patient did not wish to undergo a double-blinded placebo controlled food challenge due to her underlying medical condition.


Our patient demonstrates IgE-mediated hypersensitivity to raw wheat, including uncooked batter. Her episodes of anaphylaxis occurred on ingestion of battered fish and chicken, which may have contained raw wheat if only partially cooked. We theorize that she is sensitized to a conformational epitope. Research is warranted in this area to further explore the possibility of raw wheat allergy.

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Correspondence to L Connors.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Connors, L., Lacuesta, G., Kapur, S. et al. Raw wheat allergy: a case report. All Asth Clin Immun 6, P26 (2010).

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  • Rhinitis
  • Allergic Rhinitis
  • Food Challenge
  • Conformational Epitope
  • White Flour