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Early life nutrition, the developing immune system and subsequent allergic manifestations

Over the last half-century, chronic disease incidence, including allergic manifestations (AM), has increased exponentially in developed nations and amongst the wealthy in developing nations. Concurrently, there has been a “nutrition transition” in the same populations. Dietary patterns have shifted from a prudent diet (high fruit and vegetable-, and omega-3 fatty acid intake; low omega-6 fatty acid intake) to a western-style diet (higher levels omega-6 fats, lower amounts of fresh fruits and vegetables, and omega-3 fats). While diet can impact health at any life stage, it is likely to be most important during the fetal and infancy periods, when the immune system is immature. Based on an extensive review of the literature, we considered this hypothesis for the 3 nutritional progressions from fetal life through infancy: prenatal nutrition, breastfeeding and introduction of solid foods. While there is little conclusive evidence to support that a prudent diet is protective against AM especially after birth, modest evidence suggests that a prenatal maternal nutrition high in n-3 and micronutrients (e.g. vitamins C, D and E) protect against AM. This indicates that there may be a window of opportunity during fetal development in which allergic manifestation risk may be altered. The effect of breastfeeding on the prevention AM is unresolved. Despite this, exclusive breastfeeding to 4-6 months should be encouraged as human milk contains numerous immunological properties and is associated with other health benefits. If breastfeeding is not possible, hydrolyzed formulas seem to confer a greater protective effect than traditional formulas. Solid foods should be introduced at age 4-6 months. The order of introduction seems to have little effect on AM. At present, it is impossible to conclusively state that a particular dietary pattern or food will alter AM risk in infants. Implications for research and practice are also discussed.

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Correspondence to JLP Protudjer.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Protudjer, J., Sevenhuysen, G., Ramsey, C. et al. Early life nutrition, the developing immune system and subsequent allergic manifestations. All Asth Clin Immun 6, P3 (2010). https://doi.org/10.1186/1710-1492-6-S1-P3

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Keywords

  • Dietary Pattern
  • Exclusive Breastfeed
  • Solid Food
  • Fatty Acid Intake
  • Maternal Nutrition
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