Figure 1

H&E and anti-EPX staining of GI tissues. EPX-mAb-based immunohistochemistry provided evidence of both tissue infiltrating eosinophils and eosinophil degranulation in GI biopsies from the patient described in this cse report. In contrast to sections stained with Hematoxylin-Eosin (left panels) which displayed only nominal evidence of eosinophil infiltration and degranulation, serial sections subjected to EPX-mAb-based immunohistochemistry (right panels) displayed significant evidence (magenta staining areas) of both eosinophil infiltration and degranulation (extra-cellular deposition of granules and/or free-EPX within the tissue matrix). Each photomicrograph was obtained at an original magnification of 400× (0.29 mm² field of view). Scale bar = 50 μm.