Table 1 Investigations for persistent airway eosinophilia
Clinical measurement | 2008 | 2010 |
|---|---|---|
Blood eosinophil (×109/L) | 4.9 | 5.3 |
Total serum IgE (IU/L) | 1500 | 110 |
ANA, c-, p-ANCA | Not detected | Not detected |
Aspergillus, farm, bird precipitins | Not detected | Not detected |
Serum B12, pg/ml | 300 | 258 |
Serum LDH, IU/L | 124 | 105 |
Serum tryptase, IU/L | 5 | 3 |
Serum TARC, pg/ml | Not done | 360 |
Sputum IL-5, pg/ml | Not done | 220 |
Stool for parasites (×3) | Not detected | Not detected |
Toxocaris, Strongyloides serology | Negative | Negative |
Sinus CT | Pan sinusitis | Pan sinusitis, polyps |
Chest CT | Airspace consolidation | Minimal airspace, no nodes |
Bone marrow | Normal | No clonal abnormalities |
T-receptor rearrangements | Not done | Not detected |
PDGFR-FIP1L1, c-kit, abl-bcr | Not done | Not detected |
Cardiac MRI | Mild global hypokinesia | Normal, mitral valve prolpase |
Skin biopsy | Eosinophils, no vasculitis | Not done |
Colon biopsy | Normal, no vasculitis | Eosinophils, no vasculitis |
Bronchoscopy | BAL eosinophils 6% | Not done |