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Measured depth of subcutaneous tissue on posterolateral arm of omalizumab patients

Background

Omalizumab is a humanized antibody utilized for patients with moderate/severe allergic asthma. There is an estimated risk of anaphylaxis to omalizumab in 0.1% of patients. Omalizumab should be received in the subcutaneous tissue of the mid-posterolateral upper arm. There may be an increased risk of anaphylaxis if injections are received intramuscularly (IM). In our clinic, omalizumab is given with BD Eclipse™ Needle, which is routinely provided with the drug and has needle length 16mm. If a patient has a skin to muscle depth (STMD) less than 16mm, there is a risk of omalizumab being injected IM.

Methods

We reviewed charts in an allergy clinic where an ultrasound of the left posterolateral arm was completed to measure STMD. Patients were divided into two groups based on their STMD (>16 mm and ≤16 mm) and baseline characteristics were compared. We conducted multivariable linear regression with age, sex, BMI and race. The percentages of patients with STMD greater than 4 mm, 6 mm, 8 mm, 10 mm, and 12 mm were determined.

Results

Ultrasounds were completed on 40 patients receiving omalizumab. Three (7.5%) patients examined had >16 mm of STMD. Baseline characteristics were consistent between the groups except for BMI (p < 0.05). Sex and BMI correlated with STMD based on the linear regression analysis. Also, 35 (87.5%) patients had >4 mm STMD.

Conclusion

With provided omalizumab needles, the risk of anaphylaxis may be increased as the injections may be given IM. By reducing the needle length to 4 mm, the risk will likely be reduced.

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Correspondence to Harold L Kim.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Potts, R., Kim, L., Eeuwes, C. et al. Measured depth of subcutaneous tissue on posterolateral arm of omalizumab patients. All Asth Clin Immun 8, A5 (2012). https://doi.org/10.1186/1710-1492-8-S1-A5

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Keywords

  • Public Health
  • Asthma
  • Regression Analysis
  • Linear Regression
  • Baseline Characteristic