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Table 3 Single nucleotide polymorphisms with association with asthma

From: A systematic review of CD14 and toll-like receptors in relation to asthma in Caucasian children

Gene rs-number Alleles Number of associations Minor allel related to Association ref. No association ref.
CD14 rs2569190 C > T 1 out of 15 (duplication [20, 21]) decreased asthma severity [19] [10, 12, 13, 20, 21, 34, 3640, 4245]
CD14 rs4914 G > C 1 out of 2 (duplication [20, 21]) decreased asthma incidence [20, 21] [38]
TLR1 rs5743595 T > C 1 out of 1 atopic asthma [27] NA
TLR1 rs4833095 A > G 1 out of 1 atopic asthma [27] NA
TLR2 rs4696480 A > T 3 out of 5 (partial duplication [26, 56]) asthma/current asthma symptoms [25, 26, 56] [27, 45]
TLR2 rs3804099 T > C 1 out of 6 (partial duplication [26, 56]) nonatopic asthma (inverse) [27] [25, 26, 38, 45, 56]
TLR2 rs3804100 T > C 1 out of 6 (partial duplication [26, 56]) allergic asthma (inverse) [38] [21, 25, 26, 45, 56]
TLR2 rs1898830 A > G 1 out of 4 asthma [26] [21, 27, 56]
TLR2 rs5743708 G > A 1 out of 2 asthma severity in atopic children [59] [43]
TLR4 rs2737190 A > G 1 out of 1 (non-atopic) asthma [27] NA
TLR4 rs4986790 A > G 3 out of 10 asthma, atopic asthma and asthma severity in atopic children [34, 39, 59] [41, 4345, 55, 56, 60]
TLR4 rs4986791 C > T 1 out of 4 mild atopic asthma [34] [27, 56, 60]
TLR6 rs6531666 T > C 1 out of 1 asthma [45] NA
TLR6 rs5743789 T > A 1 out of 1 atopic asthma [27] NA
TLR6 rs5743798 C > T 1 out of 1 asthma [45] NA
TLR6 rs5743810 C > T 2 out of 5 (atopic) asthma [27, 61] [21, 45, 57]
TLR7 rs179008 A > T 1 out of 2 asthma [28] [27]
TLR8 rs2407992 G > C 1 out of 1 asthma [28] NA
TLR9 rs187084 T > C 1 out of 3 asthma [27] [21, 45]
TLR10 rs4129009 A > G 1 out of 2 atopic asthma inverse [27] [45]
TLR10 rs11096957 A > C 1 out of 3 asthma [21] [45, 57]
  1. Ref: reference, TLR: Toll-Like Receptor, NA: not applicable.
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