Table 3 Single nucleotide polymorphisms with association with asthma

CD14

rs2569190

C > T

1 out of 15 (duplication [20, 21])

decreased asthma severity

[19]

[10, 12, 13, 20, 21, 34, 36–40, 42–45]

CD14

rs4914

G > C

1 out of 2 (duplication [20, 21])

decreased asthma incidence

[20, 21]

[38]

TLR1

rs5743595

T > C

1 out of 1

atopic asthma

[27]

NA

TLR1

rs4833095

A > G

1 out of 1

atopic asthma

[27]

NA

TLR2

rs4696480

A > T

3 out of 5 (partial duplication [26, 56])

asthma/current asthma symptoms

[25, 26, 56]

[27, 45]

TLR2

rs3804099

T > C

1 out of 6 (partial duplication [26, 56])

nonatopic asthma (inverse)

[27]

[25, 26, 38, 45, 56]

TLR2

rs3804100

T > C

1 out of 6 (partial duplication [26, 56])

allergic asthma (inverse)

[38]

[21, 25, 26, 45, 56]

TLR2

rs1898830

A > G

1 out of 4

asthma

[26]

[21, 27, 56]

TLR2

rs5743708

G > A

1 out of 2

asthma severity in atopic children

[59]

[43]

TLR4

rs2737190

A > G

1 out of 1

(non-atopic) asthma

[27]

NA

TLR4

rs4986790

A > G

3 out of 10

asthma, atopic asthma and asthma severity in atopic children

[34, 39, 59]

[41, 43–45, 55, 56, 60]

TLR4

rs4986791

C > T

1 out of 4

mild atopic asthma

[34]

[27, 56, 60]

TLR6

rs6531666

T > C

1 out of 1

asthma

[45]

NA

TLR6

rs5743789

T > A

1 out of 1

atopic asthma

[27]

NA

TLR6

rs5743798

C > T

1 out of 1

asthma

[45]

NA

TLR6

rs5743810

C > T

2 out of 5

(atopic) asthma

[27, 61]

[21, 45, 57]

TLR7

rs179008

A > T

1 out of 2

asthma

[28]

[27]

TLR8

rs2407992

G > C

1 out of 1

asthma

[28]

NA

TLR9

rs187084

T > C

1 out of 3

asthma

[27]

[21, 45]

TLR10

rs4129009

A > G

1 out of 2

atopic asthma inverse

[27]

[45]

TLR10

rs11096957

A > C

1 out of 3

asthma

[21]

[45, 57]