Figure 4

The effect of transgenic Dp2 milk on airway hyper-responsiveness. Individual mice were subjected to barometric whole-body plethysmography, and the enhanced pause (Penh) values were measured in response to challenge with different doses of nebulized methacholine (Mch). The data are presented as the means ± SEM. n = 5 mice per group with two independent experiments. * indicates P < 0.05 and ** indicates P < 0.01 for unsensitized mice compared with sensitized mice fed WT milk or Dp2 milk; # indicates P < 0.05 for sensitized mice fed transgenic Dp2 milk compared with sensitized mice fed WT milk.