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Figure 1 | Allergy, Asthma & Clinical Immunology

Figure 1

From: Examination of genetic variants involved in generation and biodisposition of kinins in patients with angioedema

Figure 1

The fibrinolytic and contact pathways demonstrating the generation and catabolism of bradykinin, which clinically may present as angioedema. HMWK, high molecular weight kininogen; tPA, tissue plasminogen activator; uPA, urokinase-like plasminogen activator; PAI-1, plasminogen activator inhibitor-1; FXII, factor XII; ACE, angiotensin converting enzyme; APP, aminopeptidase P; APM, aminopeptidase M. The effect of C1inh was not included. //, blocked by C1-INH, C1 inhibitor; X, negative regulation.

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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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