Figure 1

Analysis of QAC study. A - B show the mean and standard errors of TNSS and PNIF recorded by each group at each time point during the NAC visit (significance between time points: p<0.0001). The “PNIF only” group experienced consistently low TNSS over all time points (compared to “TNSS only” group: p<0.01 at 15 minutes and 1 hour, p<0.001 at 30 minutes; compared to “TNSS +PNIF” group: p<0.05 at 15 minutes) while the “TNSS only” group had the lowest PNIF recordings throughout the study. The “TNSS+PNIF” group had comparable TNSS to the “TNSS only” group and comparable PNIF to the “PNIF only” group. C - D. All 3 groups experienced a decline in TNSS from screening to NAC visit, but not all are statistically significant. “TNSS+PNIF” group had a significant (p<0.05) decline in NAC TNSS compared to screening. However, “TNSS only” and “TNSS+PNIF” groups both had a non-significant increase in PNIF during the NAC from screening while the “PNIF only” group experienced a decline (p<0.05).