Table 2 Failed heated milk challenge
From: Powder milk: a user-friendly and safe product for heated-milk food challenge?
Patient | SPT wheal (mm) | Serum antigen specific IgE (kUA/L) | Prior reaction | Symptoms during OFC | Total amount (g protein) | Treatment | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Casein | Fresh milk | Powder milk | α-Lactalbumin | β-Lactoglobulin | Casein | Cow’s milk | |||||
1 | NA | 5 | 8 | 1.33* | NA | 0.828* | 1.94* | Hives, vomiting | Facial flushing, conjunctival erythema, abdominal pain | 4 | Antihistaminic |
2 | 3.5 | 5.5 | 13.5 | 5.04* | 1.17* | 1.32* | 6.8* | Atopic dermatitis, vomiting | Oral pruritus | 0.8 | Antihistaminic |
3 | 3 | 6 | 1.82** | 2.42** | 2.57** | 5.33** | NA | Oral pruritus, hives, sneezing | 1.84 | Antihistaminic | |
4 | NA | 4 | 7.5 | 0.545* | 0.555* | 0.505* | 0.899* | Vomiting oral pruritus | Pharyngeal pruritus persistent post challenge | 2 | None |
5 | 11 | 16 | 15.5 | 5.87* | 1.59* | 2.55* | 4.51* | Generalized hives, vomiting, dyspnea, hypotension | Uvula angioedema, throat pain | 0.0296 | Antihistaminic |
6 | 4.5 | 9 | 8 | 2.62* | 1.06* | 1.08* | 2.3* | Generalized hives, face angioedema, diarrhea | oropharyngeal & ear pruritus | 0.0036 | Antihistaminic |
7 | 6.5 | 9 | 13 | 44.6* | NA | 80.8* | >100* | Generalized hives, vomiting | Generalized hives & pruritus, vomiting | 1 | Epinephrine + antihistaminic |
8 | 6 | 10 | 10 | 2.82** | 4** | 1.99** | 3.86** | Hives, facial angioedema, vomiting | Vomiting, abdominal pain | 1.5 | Antihistaminic |
9 | 6.5 | 7.5 | 13 | NA | NA | NA | NA | Hives, diarrhea | Vomiting | 1.3 | Antihistaminic |