Fig. 1

A Severity-Based Approach to Assessing for PIDs which have been reported with Eosinophilia. The initial approach presented here is based on the history and physical exam and simple laboratory tests. This assessment may reveal independent indications for PID evaluation independent of eosinophilia. In an infant we suggest a low threshold to consider SCID and Omenn syndrome. A consideration of transplantable/severe PIDs is presented next with some phenotypic clues. Then HIES and similarly presenting conditions may be considered in patients with eczematous dermatitis ± high IgE including performing the NIH score for STAT3 deficiency. Finally, phenotypic clues for other PIDs which have been reported with eosinophilia are listed. This approach does not suggest to evaluate all patients for all disorders but to begin with considering severe causes and then let the phenotype guide investigations for particular conditions. A few conditions, such as WAS and STAT3, appear in multiple locations due to variable presentations