Characteristic | Placebo | SIT | CB | SIT/CB |
---|---|---|---|---|
(N = 22) | (N = 23) | (N = 25) | (N = 26) | |
Age (years) | 43.5 ± 11.2 | 41.8 ± 12.5 | 42.2 ± 8.6 | 43.3 ± 10.7 |
Male-no. (%) | 12 (54.5) | 11 (47.8) | 14 (56) | 14 (53.8) |
Body weight (kg) | 62.3 ± 11.5 | 61.4 ± 12.6 | 60.8 ± 14.1 | 61.8 ± 10.9 |
Current smoker-no. (%) | 4 (18.2) | 3 (13) | 2 (8) | 3 (11.5) |
Duration of disease (years) | 6.2 ± 5.2 | 5.8 ± 6.1 | 6.3 ± 4.9 | 6.3 ± 5.4 |
Mayo clinic score (MCS) | 8.5 ± 1.2 | 8.6 ± 1.8 | 8.6 ± 1.1 | 8.6 ± 1.6 |
Partial MCS | 6.1 ± 1.1 | 6.0 ± 1.4 | 6.1 ± 1.4 | 6.0 ± 1.5 |
IBDQ score | 125 ± 36 | 126 ± 32 | 123 ± 33 | 125 ± 30 |
Fecal calprotectin (mg/g) | 1.2 ± 1.1 | 1.1 ± 0.9 | 1.2 ± 0.8 | 1.1 ± 0.8 |
Site of disease-no. (%) | ||||
Rectum and sigmoid colon | 4 (18.2) | 6 (27.3) | 5 (20) | 6 (23.1) |
Left side of colon | 6 (27.3) | 6 (27.3) | 8 (32) | 6 (23.1) |
Proximal colon | 7 (31.8) | 5 (21.7) | 3 (8) | 5 (19.2) |
All of the colon | 5 (22.7) | 6 (27.3) | 9 (36) | 9 (34.6) |
Medication-no. (%) | ||||
Steroids | 3 (13.6) | 4 (17.4) | 5 (20) | 7 (26.9) |
Immunosuppressor | 7 (31.8) | 5 (21.7) | 7 (28) | 6 (23.1) |
Steroids/immunosuppressor | 6 (27.3) | 5 (21.7) | 7 (28) | 7 (26.9) |
No medication | 6 (27.3) | 9 (39.1) | 6 (24) | 6 (23.1) |
Fecal calprotectin | ||||
Before | 255.6 (38.6) | 266.8 (42.5) | 249.5 (41.3) | 253.8 (39.5) |
After | 244.8 (36.8) | 258.3 (41.7) | 241.5 (39.5) | 68.3 (8.5)* |
Hemoglobin (g/l) | ||||
Before | 122.5 ± 15.8 | 123.8 ± 17.6 | 125.6 ± 15.2 | 122.8 ± 14.5 |
After | 124.3 ± 14.2 | 123.1 ± 13.6 | 125.2 ± 11.5 | 144.6 ± 11.1* |
WBC (×10−9/l) | ||||
Before | 8.6 ± 3.2 | 8.6 ± 3.5 | 8.6 ± 3.2 | 8.5 ± 3.6 |
After | 8.3 ± 2.5 | 8.2 ± 4.1 | 8.2 ± 2.4 | 6.1 ± 1.4* |