Clinical validation of controlled exposure to birch pollen in the Environmental Exposure Unit (EEU)

Table 1 Washout periods for medications

Medication	Duration of washout prior to the pollen exposure visit
Beta-blockers, alpha-adrenoceptor blockers, currently receiving allergen immunotherapy	Not permitted
Topical alpha-adrenergic agonists	48 h
H1 receptor antagonists	7 days
Topical corticosteroids^a	7 days
Anticholinergics	7 days
Intranasal or inhaled corticosteroids	14 days
Intranasal or inhaled cromolyn	14 days
Tricyclic antidepressants and monoamine oxidase inhibitors	14 days
Leukotriene inhibitors	14 days
Systemic corticosteroids (oral)	30 days
Depot corticosteroids	60 days

Participants were asked to follow the washout periods of the medications below before the pollen exposure visit
^aHydrocortisone ≤1 % used on <10 % body surface area was permitted throughout the study

ISSN: 1710-1492