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Table 1 Washout periods for medications

From: Clinical validation of controlled exposure to birch pollen in the Environmental Exposure Unit (EEU)

Medication Duration of washout prior to the pollen exposure visit
Beta-blockers, alpha-adrenoceptor blockers, currently receiving allergen immunotherapy Not permitted
Topical alpha-adrenergic agonists 48 h
H1 receptor antagonists 7 days
Topical corticosteroidsa 7 days
Anticholinergics 7 days
Intranasal or inhaled corticosteroids 14 days
Intranasal or inhaled cromolyn 14 days
Tricyclic antidepressants and monoamine oxidase inhibitors 14 days
Leukotriene inhibitors 14 days
Systemic corticosteroids (oral) 30 days
Depot corticosteroids 60 days
  1. Participants were asked to follow the washout periods of the medications below before the pollen exposure visit
  2. aHydrocortisone ≤1 % used on <10 % body surface area was permitted throughout the study