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Table 2 Characteristics of patients presenting to the Emergency Department with Drug-Induced Anaphylaxis

From: AllerGen’s 8th research conference

Variable (%, 95% CI)

Montreal Children’s Hospital

Hôpital Sacré-Coeur

N

29

52

AAR (median, IQR)

9.67 (4.6, 15.6)

49.1 (38.0, 62.9)

Sex (% males)

37.9 (19.1, 56.7)

25.0 (12.8, 37.2)

Cases per year

 2012–2013

27.6 (10.3, 44.9)

28.8 (16.1, 41.6)

 2013–2014

31.0 (13.1, 48.9)

32.7 (19.5, 45.9)

 2014–2015

41.4 (22.3, 60.4)

38.5 (24.8, 52.1)

Medication type

 Antibiotics

34.5 (16.1, 52.9)

59.6 (45.8, 73.4)

 Non-antibiotic drugs

65.5 (47.1, 83.9)

40.4 (26.6, 54.2)

 Known drug allergy

6.9 (0, 16.7)

30.6 (17.2, 44.0)

 Known food allergy

20.7 (5.0, 36.4)

12.2 (2.7, 21.8)

 Known asthma

24.1 (7.6, 40.7)

4.1 (0, 9.8)

Reaction type

 Milda

13.8 (0.4, 27.1)

0

 Moderateb

79.3 (63.6, 95.0)

82.7 (72.0, 93.3)

 Severec

6.9 (0, 16.7)

17.3 (6.7, 27.9)

Treatment in ED

 Epinephrine

58.6 (39.6, 77.7)

48.1 (34.0, 62.1)

 Antihistamines

41.4 (22.3, 60.4)

78.8 (67.4, 90.3)

 Steroids

17.2 (2.6, 31.9)

86.5 (76.9, 96.1)

  1. aSymptoms include urticaria, erythema, angioedema, oral pruritus, nausea, nasal congestion, sneezing, rhinorrhea or throat tightness
  2. bSymptoms include crampy abdominal pain, diarrhea, recurrent vomiting, dyspnea, stridor, cough, wheeze, or “light-headedness”
  3. cSymptoms include cyanosis, hypoxia, respiratory arrest, hypotension, dysrhythmia, confusion, or loss of consciousness
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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