Box 1 Important considerations for skin prick testing

SPT reagents, testing devices, and methodology can differ significantly among health care providers in the United States or elsewhere.22 The EP recommends that specialists adjust their SPT categorization criteria according to their own training and experience.

Health care providers conducting OFCs in infants with 3 mm or greater SPT responses should be aware that the probability of a positive challenge response increases with wheal size. These data come from the HealthNuts Study in children 12 to 18 months of age; of note, the severity of these reactions was relatively mild [21, 23].