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Fig. 1 | Allergy, Asthma & Clinical Immunology

Fig. 1

From: Systemic mastocytosis with KIT V560G mutation presenting as recurrent episodes of vascular collapse: response to disodium cromoglycate and disease outcome

Fig. 1

Bone marrow cytological and histopathological features at diagnosis. a Leishman’s (A1), toluidine blue (A2) and chloroacetate esterase (A3) staining of bone marrow (BM) smears from the patient at diagnosis, revealing atypical mast cells (MCs) with elongated cytoplasmic extensions and abnormal granulation (*). A normal MC is shown for comparison (A1, **). b Hematoxilin-eosin (B1, 40×; B2, 400×), Giemsa staining (B3, 400×) and CD117 immunostaining (B4, 400×) of a BM trephine biopsy from the patient at diagnosis, showing normocellular marrow with osteosclerosis (B1, *) and scattered elongated and degranulated abnormal (B2 and B3, *), CD117 positive (B4) MCs

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