Table 1 Demographics and baseline clinical characteristics of patients with severe asthma during the 1-year look-back period
| Â | All patients with severe asthma | Patients with severe asthma stratified by eosinophil counts | |
|---|---|---|---|
< 300 cells/µL | ≥ 300 cells/µL | ||
N = 212 | n = 33 | n = 23 | |
Mean age, years (SD) | 43 (16) | 48 (15) | 51 (12) |
 Aged 12–17 years, n (%) | 4 (2) | 0 (0) | 0 (0) |
 Aged 18–34 years, n (%) | 69 (33) | 9 (27) | 1 (4) |
 Aged 35–64 years, n (%) | 119 (56) | 21 (64) | 19 (83) |
 Aged ≥ 65 years, n (%) | 20 (9) | 3 (9) | 3 (13) |
 Female, n (%) | 124 (58) | 25 (76) | 14 (61) |
Smoking history, n (%) | |||
 Current | 42 (20) | 4 (12) | 0 (0) |
 Previous | 23 (11) | 7 (21) | 3 (13) |
 Nonsmoker | 138 (65) | 19 (58) | 19 (83) |
 Unknown | 9 (4) | 3 (9) | 1 (4) |
BMI, mean (SD) | 29.2 (6.8) | 29.7 (8.0) | 29.6 (5.7) |
 < 18, n (%) | 3 (1) | 1 (3) | 0 (0) |
 18–24, n (%) | 32 (15) | 10 (30) | 5 (22) |
 25–29, n (%) | 39 (18) | 7 (21) | 6 (26) |
 ≥ 30, n (%) | 45 (21) | 11 (33) | 9 (39) |
 Unknown, n (%) | 93 (44) | 4 (12) | 3 (13) |
Respiratory specialist referral, n (%) | 43 (20) | 3 (9) | 2 (9) |
Mean blood eosinophil count, cells/μL (SD) | 303 (266) | 140 (79) | 537 (267) |
Comorbidities, n (%) | |||
 Acute bronchitis | 35 (17) | 6 (18) | 6 (26) |
 Rhinitis | 19 (9) | 3 (9) | 4 (17) |
 Sinusitis | 19 (9) | 5 (15) | 2 (9) |
 Anxiety disorders | 19 (9) | 3 (9) | 9 (39) |
 Eczema or rash | 14 (7) | 4 (12) | 3 (13) |
 Depression | 7 (3) | 1 (3) | 0 (0) |
 Diabetes | 15 (7) | 5 (15) | 5 (22) |
 Pneumonia | 5 (2) | 2 (6) | 0 (0) |
Medications, n (%) | |||
 ICS/LABAa | 70 (33) | 13 (39) | 8 (35) |
 ICSa | 34 (16) | 6 (18) | 9 (39) |
 OCS | 18 (8) | 3 (9) | 1 (4) |
 LTRA | 11 (5) | 1 (3) | 2 (9) |
 LABA | 0 (0) | 0 (0) | 0 (0) |
 Injectable CS | 0 (0) | 0 (0) | 0 (0) |
 Xanthines | 0 (0) | 0 (0) | 0 (0) |
 Omalizumab | 0 (0) | 0 (0) | 0 (0) |
 SABA | 88 (42) | 13 (39) | 9 (39) |