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Table 3 Nocturnal Rhinoconjunctivitis Quality of Life Questionnaire results (ITT population)

From: Effects of nasal dilator strips on subjective measures of sleep in subjects with chronic nocturnal nasal congestion: a randomized, placebo-controlled trial

NRQLQ itema Asymmetric placebo (n = 20) BRNS clear (n = 20) Asymmetric butterfly (n = 19)
Sleep problems b
Mean (SD) at baseline 15.10 (6.66) 14.30 (4.57) 13.63 (5.96)
Day 7
LS mean change from baseline (95% CI) − 4.19 (− 6.18 to − 2.21) − 7.40 (− 9.44 to − 5.36) − 6.56 (− 8.71 to − 4.42)
P value for comparison with placebo – P = 0.0221c P = 0.0942
P value for comparison with BRNS – – P = 0.5462
Day 14
LS mean change from baseline (95% CI) − 5.74 (− 7.74 to − 3.74) − 7.62 (− 9.68 to − 5.57) − 7.05 (− 9.21 to − 4.89)
P value for comparison with placebo   P = 0.1739 P = 0.3524
P value for comparison with BRNS    P = 0.6804
Sleep time problems d
Mean (SD) at baseline 15.75 (6.99) 15.45 (5.99) 15.84 (7.95)
Day 7
LS mean change from baseline (95% CI) − 5.64 (− 8.09 to − 3.19) − 7.49 (− 9.99 to − 5.00) − 8.21 (− 10.81 to − 5.61)
P value for comparison with placebo – P = 0.2722 P = 0.1354
P value for comparison with BRNS – – P = 0.6731
Day 14
LS mean change from baseline (95% CI) − 7.05 (− 9.49 to − 4.61) − 8.75 (− 11.24 to − 6.26) − 6.77 (− 9.36 to − 4.18)
P value for comparison with placebo – P = 0.3136 P = 0.8677
P value for comparison with BRNS – – P = 0.2463
Symptoms on waking in the morning e
Mean (SD) at baseline 16.55 (6.25) 15.80 (4.42) 14.74 (4.94)
Day 7
LS mean change from baseline (95% CI) − 4.07 (− 6.13 to − 2.02) − 7.20 (− 9.28 to − 5.11) − 7.91 (− 10.09 to − 5.72)
P value for comparison with placebo – P = 0.0298c P = 0.0099c
P value for comparison with BRNS – – P = 0.6195
Day 14
LS mean change from baseline (95% CI) − 5.32 (− 7.33 to − 3.30) − 7.86 (− 9.90 to − 5.81) − 8.00 (− 10.14 to − 5.86)
P value for comparison with placebo – P = 0.0695 P = 0.0614
P value for comparison with BRNS – – P = 0.9183
Practical problems f
Mean (SD) at baseline 7.25 (4.99) 6.05 (4.36) 6.53 (5.21)
Day 7
LS mean change from baseline (95% CI) − 2.28 (− 3.51 to − 1.04) − 2.77 (− 4.02 to − 1.52) − 3.08 (− 4.38 to − 1.78)
P value for comparison with placebo – P = 0.5564 P = 0.3500
P value for comparison with BRNS – – P = 0.7211
Day 14
LS mean change from baseline (95% CI) − 3.21 (− 4.34 to − 2.07) − 3.59 (− 4.74 to − 2.44) − 3.05 (− 4.25 to − 1.86)
P value for comparison with placebo – P = 0.6223 P = 0.8454
P value for comparison with BRNS – – P = 0.4947
  1. BRNS Breathe Right Nasal Strip, CI confidence interval, ITT intent-to-treat, LS least square, NRQLQ Nocturnal Rhinoconjunctivitis Quality of Life Questionnaire, SD standard deviation
  2. a Items in individual domains were scored on a 7-point scale where 0 = not troubled, 1 = hardly troubled, 2 = somewhat troubled, 3 = moderately troubled, 4 = quite a bit troubled, 5 = very troubled, and 6 = extremely troubled
  3. b Computed as the sum of sleep problems domain items 1, 2, 3, and 4
  4. c Significant difference between treatments
  5. d Computed as the sum of sleep time problems domain items 5, 6, 7, 8, and 9
  6. e Computed as the sum of waking in the morning domain items 10, 11, 12, and 13
  7. f Computed as the sum of practical problems domain items 14, 15, and 16
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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