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Table 3 Nocturnal Rhinoconjunctivitis Quality of Life Questionnaire results (ITT population)

From: Effects of nasal dilator strips on subjective measures of sleep in subjects with chronic nocturnal nasal congestion: a randomized, placebo-controlled trial

NRQLQ itema

Asymmetric placebo (n = 20)

BRNS clear (n = 20)

Asymmetric butterfly (n = 19)

Sleep problems b

Mean (SD) at baseline

15.10 (6.66)

14.30 (4.57)

13.63 (5.96)

Day 7

LS mean change from baseline (95% CI)

− 4.19 (− 6.18 to − 2.21)

− 7.40 (− 9.44 to − 5.36)

− 6.56 (− 8.71 to − 4.42)

P value for comparison with placebo

–

P = 0.0221c

P = 0.0942

P value for comparison with BRNS

–

–

P = 0.5462

Day 14

LS mean change from baseline (95% CI)

− 5.74 (− 7.74 to − 3.74)

− 7.62 (− 9.68 to − 5.57)

− 7.05 (− 9.21 to − 4.89)

P value for comparison with placebo

 

P = 0.1739

P = 0.3524

P value for comparison with BRNS

  

P = 0.6804

Sleep time problems d

Mean (SD) at baseline

15.75 (6.99)

15.45 (5.99)

15.84 (7.95)

Day 7

LS mean change from baseline (95% CI)

− 5.64 (− 8.09 to − 3.19)

− 7.49 (− 9.99 to − 5.00)

− 8.21 (− 10.81 to − 5.61)

P value for comparison with placebo

–

P = 0.2722

P = 0.1354

P value for comparison with BRNS

–

–

P = 0.6731

Day 14

LS mean change from baseline (95% CI)

− 7.05 (− 9.49 to − 4.61)

− 8.75 (− 11.24 to − 6.26)

− 6.77 (− 9.36 to − 4.18)

P value for comparison with placebo

–

P = 0.3136

P = 0.8677

P value for comparison with BRNS

–

–

P = 0.2463

Symptoms on waking in the morning e

Mean (SD) at baseline

16.55 (6.25)

15.80 (4.42)

14.74 (4.94)

Day 7

LS mean change from baseline (95% CI)

− 4.07 (− 6.13 to − 2.02)

− 7.20 (− 9.28 to − 5.11)

− 7.91 (− 10.09 to − 5.72)

P value for comparison with placebo

–

P = 0.0298c

P = 0.0099c

P value for comparison with BRNS

–

–

P = 0.6195

Day 14

LS mean change from baseline (95% CI)

− 5.32 (− 7.33 to − 3.30)

− 7.86 (− 9.90 to − 5.81)

− 8.00 (− 10.14 to − 5.86)

P value for comparison with placebo

–

P = 0.0695

P = 0.0614

P value for comparison with BRNS

–

–

P = 0.9183

Practical problems f

Mean (SD) at baseline

7.25 (4.99)

6.05 (4.36)

6.53 (5.21)

Day 7

LS mean change from baseline (95% CI)

− 2.28 (− 3.51 to − 1.04)

− 2.77 (− 4.02 to − 1.52)

− 3.08 (− 4.38 to − 1.78)

P value for comparison with placebo

–

P = 0.5564

P = 0.3500

P value for comparison with BRNS

–

–

P = 0.7211

Day 14

LS mean change from baseline (95% CI)

− 3.21 (− 4.34 to − 2.07)

− 3.59 (− 4.74 to − 2.44)

− 3.05 (− 4.25 to − 1.86)

P value for comparison with placebo

–

P = 0.6223

P = 0.8454

P value for comparison with BRNS

–

–

P = 0.4947

  1. BRNS Breathe Right Nasal Strip, CI confidence interval, ITT intent-to-treat, LS least square, NRQLQ Nocturnal Rhinoconjunctivitis Quality of Life Questionnaire, SD standard deviation
  2. a Items in individual domains were scored on a 7-point scale where 0 = not troubled, 1 = hardly troubled, 2 = somewhat troubled, 3 = moderately troubled, 4 = quite a bit troubled, 5 = very troubled, and 6 = extremely troubled
  3. b Computed as the sum of sleep problems domain items 1, 2, 3, and 4
  4. c Significant difference between treatments
  5. d Computed as the sum of sleep time problems domain items 5, 6, 7, 8, and 9
  6. e Computed as the sum of waking in the morning domain items 10, 11, 12, and 13
  7. f Computed as the sum of practical problems domain items 14, 15, and 16
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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