Fetal cord blood and tissue immune responses to chronic placental inflammation and chorioamnionitis

Table 3 Frequency of RORγt⁺ cells in cord blood, organized by site of maternal and/or fetal inflammation and cell type

Cell type	Chronic inflammation with no acute inflammation (n = 8/15) β ± SE	p-value
RORγt⁺ in CD3⁺CD4⁺Foxp3⁺	14.19 ± 3.59	0.002
RORγt⁺ in CD3⁺CD4⁺CD25⁺CD127^loFoxp3⁺	− 1.10 ± 2.04	0.6

Cell type	Maternal high stage acute inflammation (stage 2 and 3) (n = 2/9) β ± SE	p-value
RORγt⁺ in CD3⁺CD4⁺Foxp3⁺	4.30 ± 4.30	0.35
RORγt⁺ in CD3⁺CD4⁺CD25⁺CD127^loFoxp3⁺	− 3.97 ± 6.09	0.54

Cell type	Fetal and maternal high stage inflammation (stage 2 and 3) (n = 2/9) β ± SE	p-value
RORγt⁺ in CD3⁺CD4⁺Foxp3⁺	35.50 ± 3.80	< 0.001
RORγt⁺ in CD3⁺CD4⁺CD25⁺CD127^loFoxp3⁺	− 1.80 ± 4.28	0.68

Note that there is a significant difference in RORγt⁺ cells in activated T cells compared in individuals with chronic inflammation with no acute inflammation compared to those with neither acute or chronic inflammation (p = 0.002). Also note the increase in RORγt⁺ cells in activated T cells in subjects with maternal and fetal high stage inflammation (p < 0.001), but not in subjects with maternal high stage inflammation alone

ISSN: 1710-1492