Fig. 1

Lymph nodes from the patient (a, b) and normal control (c). Plasma cells staining with CD138 are shown in brown. a The patient has normal lymph node architecture. b Showing reduced numbers of plasma cells in the germinal centre in the patient. c The plasma cells are in the interfollicular areas in the control. CVID is typically associated with the absence of plasma cells and poorly formed germinal centres. The patient was not on immunosuppression at the time of the lymph node excision