Fig. 2

Attenuation of OVA-specific IgE and OVA-induced IL-4 (a, c) but not IgG and OVA-induced IL-2 (b, d) in groups of naïve 8 BALB/c mice immunized with OVA in alum (see “Materials and methods” and Fig. 1a) and in addition receiving anti-C3H immune serum alone, anti–anti-C3H serum alone, or a combination of the two antibodies at weekly intervals (×5 injections). All mice received egg white solution (EWS) in their drinking supply. Data show mean ± SD of IgE/IgG levels in serum, or 72 h-induced cytokines in splenocyte cultures in animals receiving a final boost of OVA in alum 7 days after the final immunoglobulin treatment and sacrificed 10 days later. The OVA alone group of mice received normal mouse serum iv. The EWS group received no immunization with OVA in alum. *p < 0.05 compared with mice receiving normal mouse serum (OVA); **p < 0.05 compared with OVA + EWS group