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Table 2 Summary of main effects of quercetin on allergic diseases (in vivo studies)

From: Quercetin with the potential effect on allergic diseases

Diseases Dosage Animal Quercetin’s effect References
Allergic asthma 7.5 mg/kg Male Dunkin-Hartley guinea pigs Inhibited the sRaw in LAR and IAR dose-dependently, as well as the recruitment of leukocytes, particularly eosinophils and neutrophils on LAR [21]
10 mg/ml Male Dunkin-Hartley guinea pigs Decreased histamine and protein contents, PLA2 activity, and recruitments of leukocytes in BAL fluid and also slightly increased infiltration of eosinophils and neutrophils in histopathological survey [27]
8 or 16 mg/kg BALB/c Decreased allergic airway inflammation and hyperresponsiveness due to the alteration of Th1/Th2 differentiation via the suppression of GATA-3 and increase of T-bet expression
Reduced the increased levels of IL-4, increased IFN-ɣ, and significantly inhibit all asthmatic reactions
[20]
10 mg/kg BALB/c Reduced eosinophil counts in BALF, blood and lung parenchyma [29]
10 mg/kg BALB/c Reduced the eosinophil recruitment, IL-4 and IL-5 levels in the BALF, as well as, inhibited the NF-κB activation, P-selectin expression and the mucus production in the lung [17]
5 mg/kg Sprague–Dawley rats Diminished the increase of total cell numbers and macrophage numbers in BALF
Decreased the neutrophil and lymphocyte counts, levels of TNF-α, IL-1β, and IL-6
[30]
16 mg/kg BALB/c Lower epithelial thickness, subepithelial smooth muscle thickness, goblet, and mast cell numbers
Lower IL-25, IL-33, TSLP, caspase-3 and TUNEL
[31]
Allergic rhinitis 460 mg of herbal extract Not animals. In AR patients Reduced total serum IgE [43]
25 mg/kg Sprague–Dawley rats Inhibit nasal rubbing movements and sneezing [44]
80 mg/kg Sprague–Dawley rats Suppressed of AR
Weaker COX-2 and VIP expressions
[45]
Atopic dermatitis Nc/Nga mouse Suppressed angiogenesis and Th2-related cytokine expression [53]
10 mg Hsd:ICR (CD-1) mice Amelioration of the tissue damage, with a noticeable attenuation of edema and leukocyte infiltration [54]
2 mg Nc/Nga mouse Decreased the iNOS and COX-2 mRNA expressions in the skin as well as significantly suppressed the increase in the level of total plasma IgE and eosinophils
Down-regulated the expression of the cytokines, IL-4, 5 and 13
[50]
Nc/Nga mouse Weakened the development of AD-like skin lesions
Inhibited hyperkeratosis, parakeratosis, acanthosis, mast cells and infiltration of inflammatory cells
Down-regulated cytoplasmic HMGB1, RAGE, nuclear p-NF-κB, p-extracellular signal-regulated kinase (ERK) 1/2, COX2, TNFα, IL-1β, IL-2Rα, IFNγ and IL-4 and up-regulated nuclear Nrf2
[55]
  1. sRaw specific airway resistance, LAR late-phase response, IAR immediate phase response, BALF bronchoalveolar lavage fluid, TSLP thymic stromal lymphopoietin, VIP vasoactive intestinal polypeptide, COX cyclooxygenase, Nrf2 nuclear factor erythroid 2-related factor 2, HMGB high mobility group box, RAGE receptor for advanced glycation end product, NF-κB nucleartranscription factor kappa B