Table 1 Participants’ characteristics
Number of patients | n = 158 |
|---|---|
Age (years) | |
Mean (range) | 5.5 (0.7–18.1) |
Gender, n (%) | |
Male | 82 (51.9) |
Personal history of atopy, n (%) | |
Any atopic condition | 71 (44.9) |
Atopic dermatitis | 47 (29.7) |
Allergic rhinitis | 29 (18.4) |
Asthma | 32 (20.3) |
Food allergy | 8 (5.1) |
Personal history of other drug allergy, n (%) | 45 (28.5) |
Family history of drug allergy, n (%) | 50 (31.6) |
Molecule of initial reaction, n (%) | |
Amoxicillin | 137 (86.7) |
Amoxicillin/clavulinic acid | 13 (8.2) |
Presumed amoxicillin | 6 (3.8) |
Penicillin V | 1 (0.6) |
Ampicillin | 1 (0.6) |
Indication for antibiotic | |
Otitis media | 80 (50.6%) |
Pharyngitis | 15 (9.5%) |
Pneumonia/bronchitis | 10 (6.3%) |
Sinusitis | 3 (1.9%) |
Scarlet fever | 3 (1.9%) |
Other | 11 (7.0%) |
Unknown | 36 (22.8%) |
Allergic reaction, n (%) | |
Rash | 158 (100.0) |
Urticaria | 59 (37.3) |
Maculopapular rash | 89 (56.3) |
Macular rash | 7 (4.4) |
Undefined rash | 2 (1.3) |
Angioedema | 11 (7.0) |
Cough/bronchospasm | 2 (1.3) |
Vomiting | 5 (3.2) |
Anaphylaxis | 0 (0.0) |
Timing of allergic reaction, n (%) | |
Within < 24 h | 27 (17.1) |
After > 24 h | 99 (62.7) |
Unknown | 32 (20.3) |
Time elapsed between initial reactions and allergy workup, years (median, interquartile range) | 1.6 (0.7–4.8) |