Skip to main content

Table 2 Lymphocytes subsets and immunoglobulin of STAT3 mutation patients

From: The clinical, immunological and genetic features of 12 Chinese patients with STAT3 mutations

  P1 P2 P3 P4 P5 P6 P7 P8 P9 P10 P11 P12
Lymphocytes subsets
 Total T cells (cells/μL) 2418.05↑ (1325–2276) 1640.43 (1325–2276) 2210.10 (1480–2847) 4180.60↑ (1775–3953) 3722.60 (1794–4247) 2748.03 (1775–3953) 2198.60 (1325–2276) 2484.20 (2187–6352) 1704.50 (1424–2664) 1524.7 (1775–3953) 3343.50 (2187–6352) 665.20↓ (1169–2071)
 Total T cells (%) 79.79↑ (57.10–73.43) 72.59 (57.10–73.43) 72.99 (59.50–75.56) 71.41 (53.37–71.91) 65.59 (53.88–72.87) 64.26 (53.37–71.91) 77.67↑ (57.10–73.43) 60.47 (55.32–73.11) 74.92 (60.05–74.08) 59.09 (53.37–71.91) 60.88 (55.32–73.11) 79.77↑ (61.29–73.13)
 CD4 T cells (cells/μL) 935.32 (531–1110) 859.30 (531–1110) 1537.59 (767–1592) 2784.37↑ (948–2477) 2073.18 (902–2253) 1900.82 (948–2477) 1346.17↑ (531–1110) 1403.91 (1125–3768) 936.74 (686–1358) 833.11 (948 –2477) 1812.96 (1125–3768) 347.24↓ (554–1109)
 CD4 T cells (%) 30.98 (24.00–38.72) 37.96 (24.00–38.72) 50.78↑ (28.49–41.07) 47.56↑ (26.19–45.48) 37.38 (24.08–42.52) 45.86 (26.19–45.48) 47.56↑ (24.00–38.72) 34.17 (28.17–47.74) 41.17 (26.17–40.76) 32.29 (26.19–45.48) 33.01 (28.17–47.74) 39.03 (26.36–40.90)
 CD8 T cells (cells/μL) 1133.59 (480–1112) 579.86 (480–1112) 620.54 (553–1127) 1291.87 (531–1521) 1480.57 (580–1735) 766.79 (531–1521) 757.71 (480–1112) 934.42 (686–2278) 521.27 (518–1125) 614.41 (531–1521) 1299.38 (686–2278) 265.24↓ (423–900)
 CD8 T cells (%) 37.26↑ (21.01–33.94) 25.29 (21.01–33.94) 20.49 (19.70–32.04) 22.07 (16.29–29.88) 25.38 (19.00–32.51) 16.60 (16.29–29.88) 26.77 (21.01–33.94) 22.74 (15.88–31.48) 22.91 (19.68–34.06) 23.81 (16.29–29.88) 23.66 (15.88–31.48) 35.13↑ (20.99–33.73)
 Total B cells (cells/μL) 334.16 (216–536) 228.69 (216–536) 719.88 (303.52–777.25) 1238.04 (537.11–1464.39) 1500.17↑ (461–1456) 1320.16 (537.11–1464.39) 560.52↑ (216–536) 957.21 (916–1832) 366.17 (280–623) 801.72 (537.11–1464.39) 1732.5 (916–1832) 116.07↓ (176.56–415.64)
 Total B cells(%) 11.23 (9.19–19.48) 11.96 (9.19–19.48) 23.78↑ (10.46–21.77) 21.15 (13.93–30.49) 26.67 (13.23–26.39) 28.15 (13.93–30.49) 19.80 (9.19–19.48) 23.30 (17.20–29.71) 16.09 (10.21–20.12) 31.07 (13.93–30.49) 31.55↑ (17.20–29.71) 16.24 (7.73–16.84)
 NK cells (cells/μL) 245.275 (246–792) 306.80 (246–792) 64.19↓ (227–668) 373.53 (241–978) 386.41 (270–1053) 329.45 (241–978) 17.08↓ (246–792) 597.21 (306–896) 190.56↓ (258–727) 208.92↓ (241–978) 384.33 (306–896) 32.05↓ (232–789)
 NK cells(%) 8.23 (10.01–26.98) 14.31 (10.01–26.98) 2.12↓ (7.83–20.99) 6.38↓ (6.53–22.24) 6.53↓ (7.21–20.90) 6.03↓ (6.53–22.24) 0.60↓ (10.01–26.98) 14.53 (5.67–15.90) 8.38↓ (9.00–22.24) 8.1 (6.53–22.24) 7.00 (5.67–15.90) 2.85↓ (11.43–27.57)
CD4/CD8 0.84 (0.81–1.66) 1.53 (0.81–1.66) 2.48↑ (1.02–2.05) 2.16 (1.05–2.53) 1.52 (0.90–2.13) 2.85 (1.05–2.53) 1.78↑ (0.81–1.66) 1.50 (0.93–2.52) 1.80 (0.87–1.94) 1.36 (1.05–2.53) 1.4 (0.93–2.52) 1.32 (0.85–1.76)
Immunoglobulin
 IgG (g/L) 13.90 9.10 17.1↑ 9.70 9.90 9.20 14.00 7.30 12.60 11.90 7.00 14.50
 IgA (g/L) 1.16 1.15 2.76↑ 0.63 0.56 0.18 0.32 0.16 1.27 0.71 0.18 1.30
 IgM (g/L) 1.07 0.86 1.23 2.32 1.36 0.72 1.99 0.77 1.51 1.23 0.37 1.84
 IgE (KU/L) 21,705.67↑↑↑ 13,472.28↑↑↑ 2660.19↑↑ 6336.65↑↑ 5021.83↑↑ 3709.67↑↑ 9015.51↑↑ 67.2 17,310.4↑↑↑ 1841.29↑↑ 43.87 221.65↑
  1. The number in round bracket presents the age specific reference values according to Reference Values for Peripheral Blood Lymphocyte Subsets of Healthy Children in China
  2. The reference value of IgG, IgA, IgM and IgE is 6.09–12.85 g/L, 0.52–2.16 g/L, 0.67–2.01 g/L and < 100 KU/L, respectively