Table 3 Participant clinical features by severity of reaction at food challenge
From: Change in exhaled nitric oxide during peanut challenge is related to severity of reaction
|  | Tolerant (n = 15) | CANA (n = 12) | p value (tolerant v CANA) | Anaphylaxis (n = 9) | p value (tolerant v anaphylaxis) | p value (CANA v anaphylaxis) |
|---|---|---|---|---|---|---|
Age (years) | ||||||
 Median (min, max) | 10.2 (7.5, 17.2) | 11.5 (6.9, 16.5) | 0.6054 | 9.2 (5.1, 14.8) | 0.3863 | 0.3918 |
Gender (%) | ||||||
 Males | 12 (80) | 6 (50) | 0.1266 | 4 (44) | 0.0994 | > 0.9999 |
Previous peanut ingestion (%) | ||||||
 Total | 12 (80) | 10 (83) | > 0.9999 | 6 (67) | 0.6349 | 0.6108 |
Previous adrenaline usage (%) | ||||||
 Total | 1 (7) | 0 (0) | > 0.9999 | 0 (0) | > 0.9999 | > 0.9999 |
Other food allergy (%) | ||||||
 Total | 2 (13) | 2 (17) | > 0.9999 | 3 (33) | 0.3256 | 0.6108 |
Household smokers (%) | ||||||
 Total | 3 (20) | 2 (17) | > 0.9999 | 2 (22) | > 0.9999 | > 0.9999 |
Allergic rhinitis (%) | ||||||
 Total | 11 (73) | 8 (67) | > 0.9999 | 7 (78) | > 0.9999 | 0.6591 |
AR severity for those with AR-max = 4a | ||||||
 Median (min, max) | 1 (1, 4) | 2 (1, 4) | 0.6599 | 2 (1, 4) | 0.9340 | 0.7436 |
Eczema ever (%) | ||||||
 Total | 11 (73) | 10 (83) | 0.6618 | 8 (89) | 0.6146 | > 0.9999 |
Eczema active treatment (%) | ||||||
 Total | 3 (20) | 2 (17) | > 0.9999 | 3 (33) | 0.6349 | 0.6108 |
SCORAD for those with visible eczema | ||||||
 Median (min, max) | 15.3 (10.7, 36.0) | 9.2 (6.0, 19.1) | 0.4000 | 16.2 (13.1, 32.5) | 0.9143 | 0.4000 |
Asthma ever (%) | ||||||
 Total | 8 (53) | 4 (33) | 0.4408 | 3 (33) | 0.4225 | >0.9999 |
Current preventer (%) | ||||||
 Total | 4 (27) | 4 (33) | > 0.9999 | 0 (0) | 0.2589 | 0.1038 |
Current reliever (%) | ||||||
 Total | 6 (40) | 4 (33) | > 0.9999 | 0 (0) | 0.0519 | 0.1038 |
Exercise related wheeze or dry nocturnal cough (%)b | ||||||
 Total | 8 (53) | 6 (50) | > 0.9999 | 2 (22) | 0.2099 | 0.3666 |
Peanut SPT (mm) | ||||||
 Median (min, max) | 3.5 (0.0, 10.0) | 7.0 (4.0, 9.0) | 0.0011 | 7.0 (5.0, 9.0) | 0.0029 | 0.6344 |
Peanut sIgE (kU/L) | ||||||
 Median (min, max) | 0.50 (0.01, 26.80) | 1.47 (0.10. 92.00) | 0.0541 | 4.80 (0.37, 80.60) | 0.0051 | 0.6640 |
Ara h2 sIgE (kU/L) | ||||||
 Median (min, max) | 0.13 (0.00, 1.00) | 1.25 (0.10, 70.30) | 0.0017 | 1.80 (0.08, 64.50) | 0.0025 | 0.9170 |
FeNO (NIOXc) (p.p.b) | ||||||
 Median (min, max) | 22 (5, 49) | 15 (5, 71) | 0.8822 | 38 (9, 97) | 0.0591 | 0.2133 |
Percent predicted FEV1d | ||||||
 Median (min, max) | 100 (86, 121) | 99 (78, 123) | 0.6354 | 108 (72, 124) | 0.9307 | 0.5941 |
Percent predicted FVCd | ||||||
 Median (min, max) | 104 (88, 128) | 99 (76, 112) | 0.2100 | 114 (70, 119) | 0.9307 | 0.3556 |
Percent predicted FEV1/FVCd | ||||||
 Median (min, max) | 95 (82, 114) | 105 (95, 111) | 0.0765 | 102 (93, 103) | 0.2273 | 0.2394 |