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Table 3 Participant clinical features by severity of reaction at food challenge

From: Change in exhaled nitric oxide during peanut challenge is related to severity of reaction

  Tolerant (n = 15) CANA (n = 12) p value (tolerant v CANA) Anaphylaxis (n = 9) p value (tolerant v anaphylaxis) p value (CANA v anaphylaxis)
Age (years)
 Median (min, max) 10.2 (7.5, 17.2) 11.5 (6.9, 16.5) 0.6054 9.2 (5.1, 14.8) 0.3863 0.3918
Gender (%)
 Males 12 (80) 6 (50) 0.1266 4 (44) 0.0994 > 0.9999
Previous peanut ingestion (%)
 Total 12 (80) 10 (83) > 0.9999 6 (67) 0.6349 0.6108
Previous adrenaline usage (%)
 Total 1 (7) 0 (0) > 0.9999 0 (0) > 0.9999 > 0.9999
Other food allergy (%)
 Total 2 (13) 2 (17) > 0.9999 3 (33) 0.3256 0.6108
Household smokers (%)
 Total 3 (20) 2 (17) > 0.9999 2 (22) > 0.9999 > 0.9999
Allergic rhinitis (%)
 Total 11 (73) 8 (67) > 0.9999 7 (78) > 0.9999 0.6591
AR severity for those with AR-max = 4a
 Median (min, max) 1 (1, 4) 2 (1, 4) 0.6599 2 (1, 4) 0.9340 0.7436
Eczema ever (%)
 Total 11 (73) 10 (83) 0.6618 8 (89) 0.6146 > 0.9999
Eczema active treatment (%)
 Total 3 (20) 2 (17) > 0.9999 3 (33) 0.6349 0.6108
SCORAD for those with visible eczema
 Median (min, max) 15.3 (10.7, 36.0) 9.2 (6.0, 19.1) 0.4000 16.2 (13.1, 32.5) 0.9143 0.4000
Asthma ever (%)
 Total 8 (53) 4 (33) 0.4408 3 (33) 0.4225 >0.9999
Current preventer (%)
 Total 4 (27) 4 (33) > 0.9999 0 (0) 0.2589 0.1038
Current reliever (%)
 Total 6 (40) 4 (33) > 0.9999 0 (0) 0.0519 0.1038
Exercise related wheeze or dry nocturnal cough (%)b
 Total 8 (53) 6 (50) > 0.9999 2 (22) 0.2099 0.3666
Peanut SPT (mm)
 Median (min, max) 3.5 (0.0, 10.0) 7.0 (4.0, 9.0) 0.0011 7.0 (5.0, 9.0) 0.0029 0.6344
Peanut sIgE (kU/L)
 Median (min, max) 0.50 (0.01, 26.80) 1.47 (0.10. 92.00) 0.0541 4.80 (0.37, 80.60) 0.0051 0.6640
Ara h2 sIgE (kU/L)
 Median (min, max) 0.13 (0.00, 1.00) 1.25 (0.10, 70.30) 0.0017 1.80 (0.08, 64.50) 0.0025 0.9170
FeNO (NIOXc) (p.p.b)
 Median (min, max) 22 (5, 49) 15 (5, 71) 0.8822 38 (9, 97) 0.0591 0.2133
Percent predicted FEV1d
 Median (min, max) 100 (86, 121) 99 (78, 123) 0.6354 108 (72, 124) 0.9307 0.5941
Percent predicted FVCd
 Median (min, max) 104 (88, 128) 99 (76, 112) 0.2100 114 (70, 119) 0.9307 0.3556
Percent predicted FEV1/FVCd
 Median (min, max) 95 (82, 114) 105 (95, 111) 0.0765 102 (93, 103) 0.2273 0.2394
  1. Italic text indicates significant p value (less than 0.05)
  2. AR allergic rhinitis, CANA clinical allergy not anaphylaxis, SCORAD SCORing Atopic Dermatitis SPT skin prick test, sIgE serum specific immunoglobulin E, FeNO fraction exhaled nitric oxide
  3. a AR severity: 1 = intermittent mild, 2 = intermittent mod-severe, 3 = persistent mild, 4 = persistent mod-severe
  4. b Exercise related wheeze or dry nocturnal cough, not related to respiratory infection in the previous 12 months
  5. c Only 33 patients were able to have FeNO measured via NIOX (14 tolerant, 11 CANA, 8 anaphylaxis)
  6. d Only 21 patients were able to have spirometry performed (6 tolerant, 10 CANA, 5 anaphylaxis)