From: Analysis of maternal and perinatal determinants of allergic sensitization in childhood
Infant related factors | Sensitized children (n = 286) | Rest of population (n = 66,583) | |||||
---|---|---|---|---|---|---|---|
n | n | P | |||||
Sex (Male) | 286 | 171 | 59.8% | 66,576 | 34,327 | 51.6% | 0.005* |
Season of birth | 286 | 66,583 | 0.806* | ||||
Spring | 66 | 23.1% | 16,241 | 24.4% | |||
Summer | 66 | 23.1% | 16,086 | 24.2% | |||
Autumn | 73 | 25.5% | 17,005 | 25.5% | |||
Winter | 81 | 28.3% | 17,251 | 25.9% | |||
Preterm (Yes) | 286 | 19 | 6.6% | 66,583 | 7701 | 11.6% | 0.009* |
Breastfed (Yes) | 250 | 208 | 83.2% | 49,619 | 38,431 | 77.5% | 0.030* |
Birth weight (kg) | 286 | 3.395 | ± 0.591 | 66,574 | 3.305 | ± 0.685 | 0.011** |
Birth length (cm) | 279 | 50.5 | ± 3.4 | 64,870 | 50.3 | ± 3.9 | 0.279** |
Birth HC (cm) | 280 | 34.5 | ± 2.1 | 65,220 | 34.3 | ± 2.3 | 0.053** |
z-score birth weight | 286 | 0.062 | ± 1.014 | 65,852 | 0.007 | ± 1.072 | 0.387** |
z-score birth length | 279 | 0.154 | ± 1.109 | 63,933 | 0.134 | ± 1.184 | 0.780** |
z-score birth HC | 280 | 0.022 | ± 0.974 | 64,455 | 0.007 | ± 1.075 | 0.798** |
Pregnancy related factors | |||||||
Conception (assisted) | 242 | 20 | 8.3% | 48,861 | 1960 | 4.0% | 0.001* |
TPL (yes) | 250 | 9 | 3.6% | 50,066 | 2403 | 4.8% | 0.639* |
Medical problem during pregnancy (yes) | 252 | 11 | 4.4% | 50,242 | 1934 | 3.8% | 0.671* |
Resuscitation intervention (yes) | 251 | 84 | 33.5% | 50,303 | 15,752 | 31.3% | 0.463* |
Delivery techniques used (yes) | 251 | 14 | 5.6% | 50,302 | 2206 | 4.4% | 0.358* |
Mode of birth (CS) | 251 | 94 | 37.5% | 50,302 | 17,188 | 34.2% | 0.274* |
Multiple birth (yes) | 286 | 10 | 3.5% | 66,583 | 2610 | 3.9% | 0.713* |
Maternal factors | |||||||
Gravidity | 286 | 1 | (0–2) | 66,575 | 2 | (1–3) | < 0.001*** |
Parity | 286 | 1 | (0–1) | 66,579 | 1 | (0–2) | 0.001*** |
BMI (kg/m2) | 243 | 49,106 | 0.017* | ||||
Underweight (< 18.5) | 33 | 13.6% | 5234 | 10.7% | |||
Normal (18.5–24.9) | 120 | 49.4% | 20,119 | 41.0% | |||
Overweight (25–29.9) | 49 | 20.2% | 11,531 | 23.5% | |||
Obesity class I (30–34.9) | 24 | 9.9% | 6676 | 13.6% | |||
Obesity class II (35–39.9) | 9 | 3.7% | 3193 | 6.5% | |||
Obesity class III (≥ 40) | 8 | 3.3% | 2353 | 4.8% | |||
Age at delivery (years) | 286 | 66,582 | 0.001* | ||||
< 20 | 13 | 4.5% | 4382 | 6.6% | |||
20–35 | 211 | 73.8% | 52,801 | 79.3% | |||
> 35 | 62 | 21.7% | 9399 | 14.1% | |||
Diabetes (Yes) | 286 | 19 | 6.6% | 66,583 | 3988 | 6.0% | 0.642* |
Smoking (Yes) | 242 | 24 | 9.9% | 48,920 | 10,348 | 21.2% | < 0.001* |
Alcohol consumption (Yes) | 242 | 1 | 0.4% | 48,797 | 877 | 1.8% | 0.139**** |
Illegal drug use (Yes) | 242 | 3 | 1.2% | 48,861 | 1133 | 2.3% | 0.387**** |
Born in Australia (Yes) | 286 | 201 | 70.3% | 66,578 | 50,849 | 76.4% | 0.015* |