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Table 4 The number of patients (%) with Cmax1 after different Tmax1

From: The pharmacokinetics of epinephrine/adrenaline autoinjectors

Group Auvi-Q® 1 Auvi-Q® 2 Epipen®
Minutes n 69 (%) 66 (%) 67 (%)
3–9 31 (45) 30 (43) 24 (36)
0–15 40 (58) 41 (61) 29 (43)
15–27 7 (10) 4 (6) 9 (13)
27–39 10 (14) 13 (20) 15 (22)
39–60 12 (17) 8 (12) 14 (21)
  1. A majority of patients had a Tmax1 less than 15 min, i.e. epinephrine reached the circulation in time to counteract the effects of general allergic reactions/anaphylaxis. A majority of these patients reached a Cmax1 before 10 min post injection. The same patients were injected once with Epipen® and twice with Auvi-Q®. Modified after Edwards [10] Table 3. Edwards gave the time in decimals of an hour; we modified to minutes and grouped data into fewer groups