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Table 4 The number of patients (%) with Cmax1 after different Tmax1

From: The pharmacokinetics of epinephrine/adrenaline autoinjectors

Group

Auvi-Q® 1

Auvi-Q® 2

Epipen®

Minutes

n 69 (%)

66 (%)

67 (%)

3–9

31 (45)

30 (43)

24 (36)

0–15

40 (58)

41 (61)

29 (43)

15–27

7 (10)

4 (6)

9 (13)

27–39

10 (14)

13 (20)

15 (22)

39–60

12 (17)

8 (12)

14 (21)

  1. A majority of patients had a Tmax1 less than 15 min, i.e. epinephrine reached the circulation in time to counteract the effects of general allergic reactions/anaphylaxis. A majority of these patients reached a Cmax1 before 10 min post injection. The same patients were injected once with Epipen® and twice with Auvi-Q®. Modified after Edwards [10] Table 3. Edwards gave the time in decimals of an hour; we modified to minutes and grouped data into fewer groups
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Allergy, Asthma & Clinical Immunology

ISSN: 1710-1492

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