Comprehensive analysis of allergen-specific IgE in COPD: mite-specific IgE specifically related to the diagnosis of asthma-COPD overlap

Table 3 Multivariate analysis of biomarkers for the diagnosis of ACO

	OR	CI		P value
Model 1
Blood eosinophils > 300 μL	1.25	0.39	4.02	0.71
FeNO > 35 ppb	15.34	3.03	77.57	< 0.01**
IgE > 100 IU/mL	6.18	1.74	21.88	< 0.01**
Model 2
Blood eosinophils > 300 μL	2.12	0.69	6.45	0.19
FeNO > 35 ppb	7.98	1.95	32.74	< 0.01**
House dust IgE positive	3.74	1.04	13.46	0.038*
Model 3
Blood eosinophils > 300 μL	2.12	0.70	6.45	0.19
FeNO > 35 ppb	7.98	1.95	32.74	< 0.01**
D. pteronyssinus IgE positive	3.74	1.04	13.46	0.038*

Specific IgE was judged as positive when the class was equal to or greater than 1. The sensitivity, specificity, positive predictive value, and negative predictive value for diagnosis of ACO are as follows: Blood eosinophils > 300 μL (44.1%, 76.2%, 60.0%, 62.7%), FeNO > 35 ppb (42.4%, 92.9%, 82.4%, 67.2%), IgE > 100 IU/mL (70.6%, 61.9%, 60.0%, 72.2%), House dust IgE positive (35.3%, 88.1%, 70.6%, 62.7%), D. pteronyssinus IgE positive (35.3%, 88.1%, 70.6%, 62.7%)
CI confidence interval, D. pteronyssinus Dermatophagoides pteronyssinus, FeNO fraction of exhaled nitric oxide, IgE immunoglobulin E, OR odds ratios

ISSN: 1710-1492