Table 1 RegiSCAR Scoring System for Classifying DRESS Cases, adapted from Cho et al. [5] applied to patients described in Case 1 and Case 2

Fever ≧ 38.5 °C

N/U

Y

0

0

Enlarged lymph nodes

N/U

Y

 > 1 cm and ≧ 2 different areas

0

0

Eosinophilia ≧ 0.7 × 10⁹/L or ≧ 10% if WBC < 4.0 × 10⁹/L

N/U

Y

Score 2, when ≧ 1.5 × 10⁹/L or ≧ 20% if WBC < 4.0 × 10⁹/L

1

1

Atypical lymphocytosis

N/U

Y

1

0

Skin rash

Rash suggesting DRESS: ≧ 2 symptoms: purpuric lesions (other than legs), infiltration, facial edema, psoriasiform desquamation

Extent > 50% of BSA

N/U

Y

1

1

Rash suggesting DRESS

N

U

Y

1

1

Skin biopsy suggesting DRESS

N

Y/U

0

0

Organ involvement

N

Y

Score 1 for each organ involvement, maximal score: 2

1

1

Rash resolution ≧ 15 days

N/U

Y

0

0

Excluding other causes

N/U

Y

Score 1 if 3 tests of the following tests were performed and all were negative: HAV, HBV, HCV, Mycoplasma, Chlamydia, ANA, blood culture

1

1

Total score

6

5