From: Autoantibodies to speckled protein family in primary biliary cholangitis
Nuclear structures | Indirect immunofluorescence pattern | Autoantigen targets | Autoantibodies in PBC | ||
---|---|---|---|---|---|
Prevalence (%) | Specificity | Worse prognosis | |||
Nuclear Bodies | MNDa | Sp100 | 17–41 | High | To be confirmed |
PML | 19 | High | No | ||
Sp140 | 15 | High | No | ||
Sp140L | 1.5 | Not assessed | Not assessed | ||
SUMO-1 | 15 | Not assessed | Not assessed | ||
SUMO-2 | 42 | Not assessed | Not assessed |