Table 1 Types of recombinant insulin with their respective clinically relevant non-medicinal ingredients
From: The complexities of insulin allergy: a case and approach
Recombinant insulin type (name and brand) | Clinically relevant non-medicinal ingredients |
|---|---|
Bolus | |
 Rapid-acting insulin analogues | |
  Insulin aspart (NovoRapid®) | Metacresol |
Zinc chloride solution | |
Disodium phosphate dihydrate | |
Glycerol | |
Hydrochloric acid | |
Sodium chloride solution | |
  Insulin faster aspart (Fiasp®) | Metacresol |
Zinc acetate | |
Phenol | |
Disodium phosphate dihydrate | |
Glycerol | |
Hydrochloric acid | |
Sodium chloride solution | |
L-arginine HCl | |
Niacinamide (vitamin B3) | |
  Insulin lispro (Humalog®, Humalog 100 units/mL) | Metacresol |
Zinc (as ion) | |
Dibasic sodium phosphate | |
Glycerol | |
Hydrochloric acid | |
Sodium hydroxide | |
  Insulin lispro (Humalog®, Humalog 200 units/mL) | Metacresol |
Zinc oxide | |
Sodium hydroxide | |
Glycerol | |
Hydrochloric acid | |
Tromethamine | |
  Insulin lispro (Admelog®) | Metacresol |
Zinc oxide | |
Dibasic sodium phosphate | |
Glycerol | |
Hydrochloric acid | |
Sodium hydroxide | |
  Insulin glulisine (Apidra®) | Metacresol |
Sodium chloride | |
Polysorbate 20 | |
Hydrochloric acid | |
Tromethamine | |
 Short-acting Insulins | |
  Insulin regular (Humulin R®) | Metacresol |
Sodium hydroxide | |
Glycerol | |
Hydrochloric acid | |
  Novolin®ge Toronto | Metacresol |
Zinc chloride | |
Glycerol | |
Sodium hydroxide | |
Hydrochloric acid | |
 Intermediate-acting insulins | |
  Humulin N® | Protamine sulfate |
Zinc oxide | |
Dibasic sodium phosphate | |
Phenol | |
  Novolin®ge NPH | Zinc chloride |
Sodium hydroxide | |
Phenol | |
Disodium phosphate dihydrate | |
Basal | |
 Long-acting basal insulin analogues | |
  Insulin detemir (Levemir®) | Metacresol |
Zinc acetate | |
Glycerol | |
Sodium hydroxide | |
Phenol | |
Disodium phosphate dihydrate | |
Hydrochloric acid | |
  Insulin glargine 100 units/mL (Lantus®) | Metacresol |
Zinc | |
Glycerol 85% | |
Polysorbate 20 | |
Hydrochloric acid | |
Sodium hydroxide | |
  Insulin glargine 100 units/mL (Basaglar®) | Metacresol |
Zinc oxide | |
Glycerol 85% | |
Polysorbate 20 | |
Hydrochloric acid | |
Sodium hydroxide | |
  Insulin glargine 300 units/mL (Toujeo®) | Metacresol |
Zinc chloride | |
Glycerol 85% | |
Hydrochloric acid | |
Sodium hydroxide | |
  Insulin degludec (Tresiba®) | Metacresol |
Zinc acetate | |
Glycerol | |
Phenol | |
Pre-mixed insulins | |
 Premixed regular insulin | |
  Humulin 30/70® | Protamine sulfate |
Zinc oxide | |
Dibasic sodium phosphate | |
Phenol | |
  Novolin®ge 30/70   Novolin®ge 40/60   Novolin®ge 50/50 | Metacresol |
Protamine sulphate | |
Zinc chloride | |
Disodium phosphate dihydrate | |
Glycerol | |
Phenol | |
Hydrochloric acid | |
Sodium hydroxide | |
 Premixed insulin analogues | |
  Biphasic insulin aspart (NovoMix 30®) | Protamine sulfate |
Metacresol | |
Zinc chloride | |
Glycerol | |
Phenol | |
Sodium chloride | |
Dibasic sodium phosphate dihydrate | |
Sodium hydroxide, | |
Hydrochloric acid | |
  Insulin lispro/lispro protamine (Humalog Mix 25®, Humalog Mix 50®) | Protamine sulfate |
Zinc oxide | |
Phenol | |