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Table 1 Types of recombinant insulin with their respective clinically relevant non-medicinal ingredients

From: The complexities of insulin allergy: a case and approach

Recombinant insulin type (name and brand) Clinically relevant non-medicinal ingredients
Bolus
 Rapid-acting insulin analogues
  Insulin aspart (NovoRapid®) Metacresol
Zinc chloride solution
Disodium phosphate dihydrate
Glycerol
Hydrochloric acid
Sodium chloride solution
  Insulin faster aspart (Fiasp®) Metacresol
Zinc acetate
Phenol
Disodium phosphate dihydrate
Glycerol
Hydrochloric acid
Sodium chloride solution
L-arginine HCl
Niacinamide (vitamin B3)
  Insulin lispro (Humalog®, Humalog 100 units/mL) Metacresol
Zinc (as ion)
Dibasic sodium phosphate
Glycerol
Hydrochloric acid
Sodium hydroxide
  Insulin lispro (Humalog®, Humalog 200 units/mL) Metacresol
Zinc oxide
Sodium hydroxide
Glycerol
Hydrochloric acid
Tromethamine
  Insulin lispro (Admelog®) Metacresol
Zinc oxide
Dibasic sodium phosphate
Glycerol
Hydrochloric acid
Sodium hydroxide
  Insulin glulisine (Apidra®) Metacresol
Sodium chloride
Polysorbate 20
Hydrochloric acid
Tromethamine
 Short-acting Insulins
  Insulin regular (Humulin R®) Metacresol
Sodium hydroxide
Glycerol
Hydrochloric acid
  Novolin®ge Toronto Metacresol
Zinc chloride
Glycerol
Sodium hydroxide
Hydrochloric acid
 Intermediate-acting insulins
  Humulin N® Protamine sulfate
Zinc oxide
Dibasic sodium phosphate
Phenol
  Novolin®ge NPH Zinc chloride
Sodium hydroxide
Phenol
Disodium phosphate dihydrate
Basal
 Long-acting basal insulin analogues
  Insulin detemir (Levemir®) Metacresol
Zinc acetate
Glycerol
Sodium hydroxide
Phenol
Disodium phosphate dihydrate
Hydrochloric acid
  Insulin glargine 100 units/mL (Lantus®) Metacresol
Zinc
Glycerol 85%
Polysorbate 20
Hydrochloric acid
Sodium hydroxide
  Insulin glargine 100 units/mL (Basaglar®) Metacresol
Zinc oxide
Glycerol 85%
Polysorbate 20
Hydrochloric acid
Sodium hydroxide
  Insulin glargine 300 units/mL (Toujeo®) Metacresol
Zinc chloride
Glycerol 85%
Hydrochloric acid
Sodium hydroxide
  Insulin degludec (Tresiba®) Metacresol
Zinc acetate
Glycerol
Phenol
Pre-mixed insulins
 Premixed regular insulin
  Humulin 30/70® Protamine sulfate
Zinc oxide
Dibasic sodium phosphate
Phenol
  Novolin®ge 30/70
  Novolin®ge 40/60
  Novolin®ge 50/50
Metacresol
Protamine sulphate
Zinc chloride
Disodium phosphate dihydrate
Glycerol
Phenol
Hydrochloric acid
Sodium hydroxide
 Premixed insulin analogues
  Biphasic insulin aspart (NovoMix 30®) Protamine sulfate
Metacresol
Zinc chloride
Glycerol
Phenol
Sodium chloride
Dibasic sodium phosphate dihydrate
Sodium hydroxide,
Hydrochloric acid
  Insulin lispro/lispro protamine (Humalog Mix 25®, Humalog Mix 50®) Protamine sulfate
Zinc oxide
Phenol