Fig. 3

Indirect effects of childhood BMI trajectory on adulthood asthma incidence via DNAm at four CpGs. The figure shows the estimates (and p-values) of direct effects at each path, based on which indirect effects of BMI trajectory were inferred. For instance, the coefficient of 1.02 indicates that the methylation at cg23632109 in the high BMI trajectory group is 1.02 higher on average compared to the DNAm in the normal BMI trajectory group. The indirect effect of BMI trajectory via cg23632109 is obtained by 1.02*0.26 = 0.27 (Table 2). Goodness of fit criteria: Chi-square test p-value > 0.05, RMSEA < 0.05, CFI > 0.95 (except cg03584646: chi-sq. < 0.05, RMSEA = 0.15, CFI = 0.78). The first CpG is for males and the remaining three CpGs are for females